A5N4Y9 (GLMM_CLOK5) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	CKL_0316

Organism

Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP]

Taxonomic identifier

431943 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	449 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 449	449	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_1000087762
Sites
	Active site	100	1	Phosphoserine intermediate By similarity
	Metal binding	100	1	Magnesium; via phosphate group By similarity
	Metal binding	241	1	Magnesium By similarity
	Metal binding	243	1	Magnesium By similarity
	Metal binding	245	1	Magnesium By similarity
Amino acid modifications
	Modified residue	100	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5N4Y9 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: 5AF61F0D3D2EBAF5	FASTA	449	49,185
	10 20 30 40 50 60 MHRMFGTDGV RGIANKELTP ELAYKLGKAG AYVLTGRCHK PKILVGMDTR ISGDMLENAL 70 80 90 100 110 120 VSGILSIGAE AICVGIVPTP AVAYLTRKYN ADAGVVISAS HNPVEYNGIK FFNGKGYKLS 130 140 150 160 170 180 DELEDKIQYV IESNFKDVSI PIGSKVGRKI METGEARKAY IEFAKSTIDT DLKDLKVVLD 190 200 210 220 230 240 CANGASYVTS VKAFQELGAK VKVINNEPDG ININHNCGST HPENLMKTVV EEGYDMGLAF 250 260 270 280 290 300 DGDADRCLAI DEKGNLINGD FIMAIIAKHL KNQGKLYKNV VVSTVMSNVG FDIALKEEGI 310 320 330 340 350 360 NTIKTQVGDR YVLEEMRKEG YKLGGEQSGH IIMLDYNTTG DGLITALQIA CIVKKSGRKL 370 380 390 400 410 420 SDIASMMKNL PQTLVNAKVP DDKKKIYMED EEIVLKIKEI ERKLHGCGRV LIRPSGTEPL 430 440 VRVMLEGEEQ GEIDKMAHNL AELIEVKLN

References

[1]

"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features." Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed: 18218779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000673 Genomic DNA. Translation: EDK32370.1.
RefSeq	YP_001393718.1. NC_009706.1.
3D structure databases
ProteinModelPortal	A5N4Y9.
ModBase	Search...
Protein-protein interaction databases
STRING	A5N4Y9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5391376.
GenomeReviews	Gene locus CKL_0316 in contig CP000673_GR.
KEGG	ckl:CKL_0316.
NMPDR	fig|431943.4.peg.347.
PATRIC	19462025. VBICloKlu111549_0359.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HBG644964.
OMA	LGLDIAC.
ProtClustDB	PRK14316.
Enzyme and pathway databases
BioCyc	CKLU431943:CKL_0316-MONOMER.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_CLOK5

Accession

Primary (citable) accession number: A5N4Y9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 10, 2007
Last modified:	December 14, 2011
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program