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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei573ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:CKL_3605
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000002411 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003347451 – 811Leucine--tRNA ligaseAdd BLAST811

Proteomic databases

PRIDEiA5N399

Interactioni

Protein-protein interaction databases

STRINGi431943.CKL_3605

Structurei

3D structure databases

ProteinModelPortaliA5N399
SMRiA5N399
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 49"HIGH" regionAdd BLAST12
Motifi570 – 574"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit

Sequencei

Sequence statusi: Complete.

A5N399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYSTKTDKKW QQKWDQTNIY TFDEKKSSKK LYTLEMFSYP SGSNLHAGHW
60 70 80 90 100
FNYAPVDSWA RMKRMQGYNV FQPMGFDAFG LPAENYAIKT GIHPKDSTEK
110 120 130 140 150
NIDTMEKQLK SMGAMFNWEN EVVTCRPDYY KWNQWLFLQL YKHDLAYRKN
160 170 180 190 200
APVNWCPSCN TVLANEQVKE GECERCGTEV TKKDLTQWFF KITDYTEELL
210 220 230 240 250
KDLDNIDWPE KTKAMQRHWM GKSTGTDVTF KVADSDIKFN VFTTRVDTLF
260 270 280 290 300
GVTYVVISPE NDLVDSVTKE EYKEEIEKYR EAAKKQTDIE RQSITREKTG
310 320 330 340 350
VSTGSYAINP INGRKVPIWI GDYVLNTYGT GAVMAVPAHD ERDFEFATKY
360 370 380 390 400
KLPIERVIEG GSSLPYVEYG KMINSDKFNG LYTPEGKEAV TKELENIGLG
410 420 430 440 450
SGKTNYRLRD WLVSRQRYWG TPIPIIYCKK CGTVPVPESD LPVELPYNVQ
460 470 480 490 500
FSPDGKSPLL KSEEFMNTTC PICGEPAKRE ADTLDTFVCS SWYYLRYADN
510 520 530 540 550
KNTEKAFDKD KINKLLPVDM YVGGPEHACM HLLYARFITK ALRDMGFLNF
560 570 580 590 600
DEPFLSLRHQ GLILGPDGQK MSKSKGNTIS PDDCIQKYGS DVFRMYLMFG
610 620 630 640 650
FDYAEGGAWN DDGIKSMSKF VDRIERIVGN IKELINSGKN FKNSMDAAEK
660 670 680 690 700
ELNYSRNYSI KSVSEDAGKF QFNTAIARIM EFTNSLYKYI QEDTKNISLL
710 720 730 740 750
KDTILDFIKI IAPFAPHFAE EQWEVLGQKY SIFNEKWPEF DPKALVKEEV
760 770 780 790 800
EIAIQINGKI KAKINIPTNL SDEQIKELSI SNDNIKPLLE GKNIKKVIVV
810
KGRLVNIVVK P
Length:811
Mass (Da):93,287
Last modified:July 10, 2007 - v1
Checksum:i4F9A8EF4DF120AC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000673 Genomic DNA Translation: EDK35595.1
RefSeqiWP_012103927.1, NC_009706.1

Genome annotation databases

EnsemblBacteriaiEDK35595; EDK35595; CKL_3605
KEGGickl:CKL_3605

Similar proteinsi

Entry informationi

Entry nameiSYL_CLOK5
AccessioniPrimary (citable) accession number: A5N399
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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