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A5N2N8

- PGK_CLOK5

UniProt

A5N2N8 - PGK_CLOK5

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381SubstrateUniRule annotation
    Binding sitei122 – 1221SubstrateUniRule annotation
    Binding sitei155 – 1551SubstrateUniRule annotation
    Binding sitei206 – 2061ATPUniRule annotation
    Binding sitei297 – 2971ATP; via carbonyl oxygenUniRule annotation
    Binding sitei328 – 3281ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi354 – 3574ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciCKLU431943:GJF1-3374-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:CKL_3381
    OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
    Taxonomic identifieri431943 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
    ProteomesiUP000002411: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 398398Phosphoglycerate kinasePRO_1000076585Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi431943.CKL_3381.

    Structurei

    3D structure databases

    ProteinModelPortaliA5N2N8.
    SMRiA5N2N8. Positions 3-398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 253Substrate bindingUniRule annotation
    Regioni61 – 644Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227108.
    KOiK00927.
    OMAiAGHPVGK.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5N2N8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVFNKKTIED VDVKGKRVLV RCDFNVPLQE GKITDENRLI GSLPTIKYLM    50
    ENNAKVILCS HLGKPKGEVK PEMSLLPVAK RLSELLKKEV VFAADDNVVG 100
    ENAKAAVKNM KDGDVILLQN TRYRIEETKN QDNFSKELAS LGEIFVNDAF 150
    GTAHRAHCST VGVTKFLPTA VCGYLIQKEL EFLGNAIENP SRPFTAILGG 200
    VKVSDKINVI NNLLEKVDTL IIGGGMSYTF ARAQGYTIGT SVVEEDKIEY 250
    AKEMIDKAKE KGIKLLLPID RVVTDKFDES AEPILEDDKN IKDGYMGMDI 300
    GPKTAKVYAD AIKDSKTIIW NGPMGVFEFK NFAKGTFAVA KAMAESGAIT 350
    IIGGGDSAAA INQLGFGDKM THISTGGGAS LEFLGGEELP GISALNNK 398
    Length:398
    Mass (Da):43,173
    Last modified:July 10, 2007 - v1
    Checksum:i5D91250193455F39
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000673 Genomic DNA. Translation: EDK35384.1.
    RefSeqiYP_001396755.1. NC_009706.1.

    Genome annotation databases

    EnsemblBacteriaiEDK35384; EDK35384; CKL_3381.
    GeneIDi5391787.
    KEGGickl:CKL_3381.
    PATRICi19468320. VBICloKlu111549_3485.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000673 Genomic DNA. Translation: EDK35384.1 .
    RefSeqi YP_001396755.1. NC_009706.1.

    3D structure databases

    ProteinModelPortali A5N2N8.
    SMRi A5N2N8. Positions 3-398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 431943.CKL_3381.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai EDK35384 ; EDK35384 ; CKL_3381 .
    GeneIDi 5391787.
    KEGGi ckl:CKL_3381.
    PATRICi 19468320. VBICloKlu111549_3485.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227108.
    KOi K00927.
    OMAi AGHPVGK.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci CKLU431943:GJF1-3374-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

    Entry informationi

    Entry nameiPGK_CLOK5
    AccessioniPrimary (citable) accession number: A5N2N8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3