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A5N2N8

- PGK_CLOK5

UniProt

A5N2N8 - PGK_CLOK5

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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381SubstrateUniRule annotation
Binding sitei122 – 1221SubstrateUniRule annotation
Binding sitei155 – 1551SubstrateUniRule annotation
Binding sitei206 – 2061ATPUniRule annotation
Binding sitei297 – 2971ATP; via carbonyl oxygenUniRule annotation
Binding sitei328 – 3281ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi354 – 3574ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCKLU431943:GJF1-3374-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:CKL_3381
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002411: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Phosphoglycerate kinasePRO_1000076585Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi431943.CKL_3381.

Structurei

3D structure databases

ProteinModelPortaliA5N2N8.
SMRiA5N2N8. Positions 3-398.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 253Substrate bindingUniRule annotation
Regioni61 – 644Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0126.
HOGENOMiHOG000227108.
KOiK00927.
OMAiAGHPVGK.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5N2N8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVFNKKTIED VDVKGKRVLV RCDFNVPLQE GKITDENRLI GSLPTIKYLM
60 70 80 90 100
ENNAKVILCS HLGKPKGEVK PEMSLLPVAK RLSELLKKEV VFAADDNVVG
110 120 130 140 150
ENAKAAVKNM KDGDVILLQN TRYRIEETKN QDNFSKELAS LGEIFVNDAF
160 170 180 190 200
GTAHRAHCST VGVTKFLPTA VCGYLIQKEL EFLGNAIENP SRPFTAILGG
210 220 230 240 250
VKVSDKINVI NNLLEKVDTL IIGGGMSYTF ARAQGYTIGT SVVEEDKIEY
260 270 280 290 300
AKEMIDKAKE KGIKLLLPID RVVTDKFDES AEPILEDDKN IKDGYMGMDI
310 320 330 340 350
GPKTAKVYAD AIKDSKTIIW NGPMGVFEFK NFAKGTFAVA KAMAESGAIT
360 370 380 390
IIGGGDSAAA INQLGFGDKM THISTGGGAS LEFLGGEELP GISALNNK
Length:398
Mass (Da):43,173
Last modified:July 10, 2007 - v1
Checksum:i5D91250193455F39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000673 Genomic DNA. Translation: EDK35384.1.
RefSeqiYP_001396755.1. NC_009706.1.

Genome annotation databases

EnsemblBacteriaiEDK35384; EDK35384; CKL_3381.
GeneIDi5391787.
KEGGickl:CKL_3381.
PATRICi19468320. VBICloKlu111549_3485.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000673 Genomic DNA. Translation: EDK35384.1 .
RefSeqi YP_001396755.1. NC_009706.1.

3D structure databases

ProteinModelPortali A5N2N8.
SMRi A5N2N8. Positions 3-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 431943.CKL_3381.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EDK35384 ; EDK35384 ; CKL_3381 .
GeneIDi 5391787.
KEGGi ckl:CKL_3381.
PATRICi 19468320. VBICloKlu111549_3485.

Phylogenomic databases

eggNOGi COG0126.
HOGENOMi HOG000227108.
KOi K00927.
OMAi AGHPVGK.
OrthoDBi EOG64N9Z0.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00185 .
BioCyci CKLU431943:GJF1-3374-MONOMER.

Family and domain databases

Gene3Di 3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPi MF_00145. Phosphoglyc_kinase.
InterProi IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view ]
PANTHERi PTHR11406. PTHR11406. 1 hit.
Pfami PF00162. PGK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000724. Pgk. 1 hit.
PRINTSi PR00477. PHGLYCKINASE.
SUPFAMi SSF53748. SSF53748. 1 hit.
PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Entry informationi

Entry nameiPGK_CLOK5
AccessioniPrimary (citable) accession number: A5N2N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3