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A5N2L5

- PYRF_CLOK5

UniProt

A5N2L5 - PYRF_CLOK5

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Protein
Orotidine 5'-phosphate decarboxylase
Gene
pyrF, CKL_3358
Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei97 – 971Proton donor By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  2. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

BioCyciCKLU431943:GJF1-3351-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Gene namesi
Name:pyrF
Ordered Locus Names:CKL_3358
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Orotidine 5'-phosphate decarboxylaseUniRule annotation
PRO_1000085573Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi431943.CKL_3358.

Structurei

3D structure databases

ProteinModelPortaliA5N2L5.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000245747.
KOiK01591.
OMAiCRTSNAG.
OrthoDBiEOG6DZF33.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01215. OMPdecase_type2.
InterProiIPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR02127. pyrF_sub2. 1 hit.

Sequencei

Sequence statusi: Complete.

A5N2L5-1 [UniParc]FASTAAdd to Basket

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MIIDELYETV NKKGNVCVGL DTALSYIPES MRESHENVED CIFEFNRTII    50
DSTLDAAACY KVQIAYYEAL GIEGLRAYSK TLKYIKDKKA LSIADIKRGD 100
IAKTAEMYAK AHFEGEFESD FVTLNPYMGF DTIEPYLPYV KNNNKGLFIL 150
IRTSNKGAKD LQYISTRKNT KLYNIVGKKV SSLGEKYMGN CGYSSLGGVM 200
GCTHQEEGIK LRKKLKNIFF LIPGYGAQGG TAEDISAYLK RGNGGVVNSS 250
RGILLAYKKE EDGFKKYGEC ARQECVKIRD DILKISQNKN S 291
Length:291
Mass (Da):32,584
Last modified:July 10, 2007 - v1
Checksum:iA952C1DEBE21ABBD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000673 Genomic DNA. Translation: EDK35361.1.
RefSeqiWP_012103691.1. NC_009706.1.
YP_001396732.1. NC_009706.1.

Genome annotation databases

EnsemblBacteriaiEDK35361; EDK35361; CKL_3358.
GeneIDi5393973.
KEGGickl:CKL_3358.
PATRICi19468274. VBICloKlu111549_3462.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000673 Genomic DNA. Translation: EDK35361.1 .
RefSeqi WP_012103691.1. NC_009706.1.
YP_001396732.1. NC_009706.1.

3D structure databases

ProteinModelPortali A5N2L5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 431943.CKL_3358.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EDK35361 ; EDK35361 ; CKL_3358 .
GeneIDi 5393973.
KEGGi ckl:CKL_3358.
PATRICi 19468274. VBICloKlu111549_3462.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000245747.
KOi K01591.
OMAi CRTSNAG.
OrthoDBi EOG6DZF33.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci CKLU431943:GJF1-3351-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01215. OMPdecase_type2.
InterProi IPR013785. Aldolase_TIM.
IPR011995. OMPdecase_type-2.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR02127. pyrF_sub2. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Entry informationi

Entry nameiPYRF_CLOK5
AccessioniPrimary (citable) accession number: A5N2L5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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