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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase (pyrE)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei97Proton donorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Short name:
OMPDCaseUniRule annotation
Short name:
OMPdecaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:CKL_3358
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
Proteomesi
  • UP000002411 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000855731 – 291Orotidine 5'-phosphate decarboxylaseAdd BLAST291

Proteomic databases

PRIDEiA5N2L5

Interactioni

Protein-protein interaction databases

STRINGi431943.CKL_3358

Structurei

3D structure databases

ProteinModelPortaliA5N2L5
SMRiA5N2L5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105SKN Bacteria
COG0284 LUCA
HOGENOMiHOG000245747
KOiK01591
OMAiQSAFFER
OrthoDBiPOG091H09O1

Family and domain databases

Gene3Di3.20.20.70, 1 hit
HAMAPiMF_01215 OMPdecase_type2, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR011995 OMPdecase_type-2
IPR001754 OMPdeCOase_dom
IPR011060 RibuloseP-bd_barrel
PANTHERiPTHR43375 PTHR43375, 1 hit
PfamiView protein in Pfam
PF00215 OMPdecase, 1 hit
SMARTiView protein in SMART
SM00934 OMPdecase, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit
TIGRFAMsiTIGR02127 pyrF_sub2, 1 hit

Sequencei

Sequence statusi: Complete.

A5N2L5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIDELYETV NKKGNVCVGL DTALSYIPES MRESHENVED CIFEFNRTII
60 70 80 90 100
DSTLDAAACY KVQIAYYEAL GIEGLRAYSK TLKYIKDKKA LSIADIKRGD
110 120 130 140 150
IAKTAEMYAK AHFEGEFESD FVTLNPYMGF DTIEPYLPYV KNNNKGLFIL
160 170 180 190 200
IRTSNKGAKD LQYISTRKNT KLYNIVGKKV SSLGEKYMGN CGYSSLGGVM
210 220 230 240 250
GCTHQEEGIK LRKKLKNIFF LIPGYGAQGG TAEDISAYLK RGNGGVVNSS
260 270 280 290
RGILLAYKKE EDGFKKYGEC ARQECVKIRD DILKISQNKN S
Length:291
Mass (Da):32,584
Last modified:July 10, 2007 - v1
Checksum:iA952C1DEBE21ABBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000673 Genomic DNA Translation: EDK35361.1
RefSeqiWP_012103691.1, NC_009706.1

Genome annotation databases

EnsemblBacteriaiEDK35361; EDK35361; CKL_3358
KEGGickl:CKL_3358

Similar proteinsi

Entry informationi

Entry nameiPYRF_CLOK5
AccessioniPrimary (citable) accession number: A5N2L5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: May 23, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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