Reviewed, UniProtKB/Swiss-Prot A5N0Z3 (DEOC_CLOK5)

Names and origin

Protein names

Recommended name:
    Deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA

Gene names

Name:	deoC
Ordered Locus Names:	CKL_2777

Organism

Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) [Complete proteome] [HAMAP]

Taxonomic identifier

431943 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	218 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde. HAMAP MF_00114
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose 1-phosphate: step 2/2. HAMAP MF_00114
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 1 subfamily.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate catabolic process Inferred from electronic annotation. Source: HAMAP deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	deoxyribose-phosphate aldolase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 218	218	Deoxyribose-phosphate aldolase HAMAP MF_00114		PRO_1000076028
Sites
	Active site	155	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	184	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5N0Z3-1 [UniParc]. Last modified July 10, 2007. Version 1. Checksum: A47504B5AB52B1CB	FASTA	218	23,545
	10 20 30 40 50 60 MDKKELAKMI DHTLLKPEAN YEQIVKLCKE ALEYGFASVC INPCYVNAAY QLLKGSDVKV 70 80 90 100 110 120 CTVVGFPLGA ATSETKTFEA VQAVNRGASE IDMVINVGYL KSGNHDYVEE DIKTLVNKIN 130 140 150 160 170 180 GRALVKVIIE TCLLNDEEKI IACKLAKKAG AHFVKTSTGF NMSGATSEDV ALMYDAVSPN 190 200 210 LKVKASGGIR TYEDAIKMIN AGASRIGASS SIKIINKK

References

[1]

"The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features." Seedorf H., Fricke W.F., Veith B., Brueggemann H., Liesegang H., Strittmatter A., Miethke M., Buckel W., Hinderberger J., Li F., Hagemeier C., Thauer R.K., Gottschalk G. Proc. Natl. Acad. Sci. U.S.A. 105:2128-2133(2008) [PubMed: 18218779] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000673 Genomic DNA. Translation: EDK34789.1.
RefSeq	YP_001396160.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5392484.
GenomeReviews	Gene locus CKL_2777 in contig CP000673_GR.
KEGG	ckl:CKL_2777.
NMPDR	fig|431943.4.peg.2826.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	A5N0Z3. AKMIDHT.
Family and domain databases
HAMAP	MF_00114. [Tree]
InterPro	IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DEOC_CLOK5

Accession

Primary (citable) accession number: A5N0Z3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	July 10, 2007
Last modified:	June 16, 2009
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)