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A5N0Q2

- PUR5_CLOK5

UniProt

A5N0Q2 - PUR5_CLOK5

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, CKL_2686
Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCKLU431943:GJF1-2679-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:CKL_2686
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002411: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 331331Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000083454Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi431943.CKL_2686.

Structurei

3D structure databases

ProteinModelPortaliA5N0Q2.
SMRiA5N0Q2. Positions 16-328.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229091.
KOiK01933.
OMAiVIGKIEH.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

A5N0Q2-1 [UniParc]FASTAAdd to Basket

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MVTYKDSGVN IEEGYKSVKL MKEYSAQTFI PGVLNGLGSF AGMFELGKYK    50
NPVLVSGTDG VGTKLKIAFE MKIYDTVGID CVAMCVNDIL CHGAKPLFFL 100
DYLACSNLEA EVAAELVKGI SKGCMDAGCA LIGGETAEMP GFYSKGEYDM 150
AGFAVGVVEK DNIINGSTVE EGDVLVGIAS SGVHSNGYSL VRKLVDNFQV 200
DFFGSALGEV LLTPTRIYVK PVLKLLEKFK IKAMAHITGG GFYENIPRMF 250
KEDFTAVIDK NSFEMPEIFK YIMDLGVDEE HMYNTYNMGI GFVLCVDSKD 300
APDIIKDLNE MGEKAYIIGH VKRREKRVCL K 331
Length:331
Mass (Da):36,276
Last modified:July 10, 2007 - v1
Checksum:i0E04A618EE4C7579
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000673 Genomic DNA. Translation: EDK34698.1.
RefSeqiWP_012103028.1. NC_009706.1.
YP_001396069.1. NC_009706.1.

Genome annotation databases

EnsemblBacteriaiEDK34698; EDK34698; CKL_2686.
GeneIDi5390661.
KEGGickl:CKL_2686.
PATRICi19466911. VBICloKlu111549_2790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000673 Genomic DNA. Translation: EDK34698.1 .
RefSeqi WP_012103028.1. NC_009706.1.
YP_001396069.1. NC_009706.1.

3D structure databases

ProteinModelPortali A5N0Q2.
SMRi A5N0Q2. Positions 16-328.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 431943.CKL_2686.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EDK34698 ; EDK34698 ; CKL_2686 .
GeneIDi 5390661.
KEGGi ckl:CKL_2686.
PATRICi 19466911. VBICloKlu111549_2790.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229091.
KOi K01933.
OMAi VIGKIEH.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci CKLU431943:GJF1-2679-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Entry informationi

Entry nameiPUR5_CLOK5
AccessioniPrimary (citable) accession number: A5N0Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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