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A5N0Q0

- PUR9_CLOK5

UniProt

A5N0Q0 - PUR9_CLOK5

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciCKLU431943:GJF1-2677-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:CKL_2684
OrganismiClostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680)
Taxonomic identifieri431943 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesClostridiaceaeClostridium
ProteomesiUP000002411: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 499499Bifunctional purine biosynthesis protein PurHPRO_1000076479Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi431943.CKL_2684.

Structurei

3D structure databases

ProteinModelPortaliA5N0Q0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiRAFKTDP.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

A5N0Q0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MINRALISVY NKEGLLELAQ FLKNKGVELI STGGTYKYLE QNDIQVTEVS
60 70 80 90 100
KITGFDEILD GRVKTLHPVI HSGILAKRDN KEHMDTIAKK DILPIDMVVV
110 120 130 140 150
NLYPFFDKVD DNITFEEKVE FIDIGGPTMI RAAAKNFKDV IVVTDVGDYS
160 170 180 190 200
KLIEEIDSKG DVPYDFRKKL AGKVFNLMSA YDGAISNFLL EEDYPEYLSL
210 220 230 240 250
SYKKMDNLRY GENPHQSAAY YTATAGTAPM KDFTQLNGKQ LSYNNIKDMD
260 270 280 290 300
IAWKVVNEFE EICCVAVKHN TPCGVALGKD LYEAYVKTYE CDPTSIFGGI
310 320 330 340 350
IAVNRKLDVK TAEEISKIFV EIVIAPDFDE EALKVLMEKK NLRIIKCSVK
360 370 380 390 400
PTNSMEIAKV DGGILVQSAD DKLVENMEVV TDKKPSKEEI NNLIFGMKVC
410 420 430 440 450
KYVKSNAIVV VKDFMAKGIG GGQVNRIWPT CHALDRAGDG VVLASDAFFP
460 470 480 490
FNDVVCEAAK YGIKAIIQPG GSVRDKDSIE ECNKNGISMV FTGVRHFKH
Length:499
Mass (Da):55,653
Last modified:July 10, 2007 - v1
Checksum:iC01A33D8D18AD82A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000673 Genomic DNA. Translation: EDK34696.1.
RefSeqiWP_012103026.1. NC_009706.1.
YP_001396067.1. NC_009706.1.

Genome annotation databases

EnsemblBacteriaiEDK34696; EDK34696; CKL_2684.
GeneIDi5390659.
KEGGickl:CKL_2684.
PATRICi19466907. VBICloKlu111549_2788.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000673 Genomic DNA. Translation: EDK34696.1 .
RefSeqi WP_012103026.1. NC_009706.1.
YP_001396067.1. NC_009706.1.

3D structure databases

ProteinModelPortali A5N0Q0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 431943.CKL_2684.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai EDK34696 ; EDK34696 ; CKL_2684 .
GeneIDi 5390659.
KEGGi ckl:CKL_2684.
PATRICi 19466907. VBICloKlu111549_2788.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi RAFKTDP.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci CKLU431943:GJF1-2677-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 8527 / DSM 555 / NCIMB 10680.

Entry informationi

Entry nameiPUR9_CLOK5
AccessioniPrimary (citable) accession number: A5N0Q0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 10, 2007
Last modified: October 29, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3