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Protein

UvrABC system protein B

Gene

uvrB

Organism
Streptococcus pneumoniae SP14-BS69
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA2B2 complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi44 – 51ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionExcision nucleaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA excisionUniRule annotationSAAS annotation, DNA repair, SOS responseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
UvrABC system protein BUniRule annotationSAAS annotation
Short name:
Protein UvrBUniRule annotation
Alternative name(s):
Excinuclease ABC subunit BUniRule annotation
Gene namesi
Name:uvrBUniRule annotation
ORF Names:CGSSp14BS69_04278Imported
OrganismiStreptococcus pneumoniae SP14-BS69Imported
Taxonomic identifieri406560 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
Proteomesi
  • UP000004914 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliA5M7I9.
SMRiA5M7I9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 188Helicase ATP-bindingInterPro annotationAdd BLAST158
Domaini435 – 601Helicase C-terminalInterPro annotationAdd BLAST167
Domaini626 – 661UVRInterPro annotationAdd BLAST36

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili622 – 649Sequence analysisAdd BLAST28

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 120Beta-hairpinUniRule annotationAdd BLAST24

Domaini

The beta-hairpin motif is involved in DNA binding.UniRule annotation

Sequence similaritiesi

Belongs to the UvrB family.UniRule annotationSAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

CDDicd00079. HELICc. 1 hit.
Gene3Di4.10.860.10. 1 hit.
HAMAPiMF_00204. UvrB. 1 hit.
InterProiView protein in InterPro
IPR006935. Helicase/UvrB_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR001943. UVR_dom.
IPR036876. UVR_dom_sf.
IPR004807. UvrB.
IPR024759. UvrB_YAD/RRR_dom.
PANTHERiPTHR24029. PTHR24029. 1 hit.
PfamiView protein in Pfam
PF00271. Helicase_C. 1 hit.
PF04851. ResIII. 1 hit.
PF02151. UVR. 1 hit.
PF12344. UvrB. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF46600. SSF46600. 1 hit.
SSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00631. uvrb. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS50151. UVR. 1 hit.

Sequencei

Sequence statusi: Complete.

A5M7I9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINHITDNQF KLVSKYQPSG DQPQAIEQLV DNIEGGEKAQ ILMGATGTGK
60 70 80 90 100
TYTMSQVISK VNKPTLVIAH NKTLAGQLYG EFKEFFPENA VEYFVSYYDY
110 120 130 140 150
YQPEAYVPSS DTYIEKDSSV NDEIDKLRHS ATSALLERND VIVVASVSCI
160 170 180 190 200
YGLGSPKEYA DSVVSLRPGL EISRDKLLND LVDIQFERND IDFQRGRFRV
210 220 230 240 250
RGDVVEIFPA SRDEHAFRVE FFGDEIDRIR EVEALTGQVL GEVDHLAIFP
260 270 280 290 300
ATHFVTNDDH MEVAIAKIQA ELEEQLAVFE KEGKLLEAQR LKQRTEYDIE
310 320 330 340 350
MLREMGYTNG VENYSRHMDG RSEGEPPYTL LDFFPDDFLI MIDESHMTIG
360 370 380 390 400
QIKGMYNGDR SRKEMLVNYG FRLPSALDNR PLRREEFESH VHQIVYVSAT
410 420 430 440 450
PGDYENEQTE TVIEQIIRPT GLLDPEVEVR PTMGQIDDLL GEINARVEKN
460 470 480 490 500
ERTFITTLTK KMAEDLTDYF KEMGIKVKYM HSDIKTLERT EIIRDLRLGV
510 520 530 540 550
FDVLVGINLL REGIDVPEVS LVAILDADKE GFLRNERGLI QTIGRAARNS
560 570 580 590 600
EGHVIMYADT VTQSMQRAID ETARRRKIQM AYNEEHGIVP QTIKKEIRDL
610 620 630 640 650
IAVTKAVAKE EDKEVDINSL NKQERKELVK KLEKQMQEAV EVLDFELAAQ
660
IRDMMLEVKA LD
Length:662
Mass (Da):75,734
Last modified:July 10, 2007 - v1
Checksum:iC2EB617ED537BDD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
ABAD01000005 Genomic DNA. Translation: EDK66210.1.

Genome annotation databases

EnsemblBacteriaiEDK66210; EDK66210; CGSSp14BS69_04278.

Similar proteinsi

Entry informationi

Entry nameiA5M7I9_STREE
AccessioniPrimary (citable) accession number: A5M7I9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteomeImported