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Protein

D-galactonate dehydratase family member VSWAT3_13707

Gene

VSWAT3_13707

Organism
Vibrionales bacterium (strain SWAT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi205Magnesium1 Publication1
Binding sitei207Sugar ester1
Metal bindingi231Magnesium1 Publication1
Metal bindingi257Magnesium1 Publication1
Binding sitei257Sugar ester1
Binding sitei278Sugar ester1
Binding sitei307Sugar ester1
Binding sitei334Sugar ester1

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • magnesium ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciVBAC391574:G12RR-310-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
D-galactonate dehydratase family member VSWAT3_13707
Gene namesi
ORF Names:VSWAT3_13707
OrganismiVibrionales bacterium (strain SWAT-3)
Taxonomic identifieri391574 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesunclassified Vibrionales
Proteomesi
  • UP000004912 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004299171 – 399D-galactonate dehydratase family member VSWAT3_13707Add BLAST399

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi391574.VSWAT3_13707.

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 14Combined sources10
Beta strandi16 – 19Combined sources4
Beta strandi21 – 28Combined sources8
Beta strandi33 – 37Combined sources5
Helixi44 – 53Combined sources10
Helixi55 – 59Combined sources5
Helixi67 – 76Combined sources10
Helixi84 – 105Combined sources22
Helixi109 – 113Combined sources5
Beta strandi117 – 131Combined sources15
Helixi132 – 144Combined sources13
Beta strandi149 – 155Combined sources7
Helixi157 – 159Combined sources3
Helixi161 – 163Combined sources3
Beta strandi172 – 175Combined sources4
Helixi178 – 196Combined sources19
Beta strandi199 – 205Combined sources7
Helixi212 – 222Combined sources11
Helixi223 – 225Combined sources3
Beta strandi228 – 231Combined sources4
Helixi239 – 241Combined sources3
Helixi242 – 246Combined sources5
Beta strandi253 – 255Combined sources3
Helixi262 – 270Combined sources9
Beta strandi275 – 277Combined sources3
Helixi281 – 284Combined sources4
Helixi287 – 300Combined sources14
Beta strandi310 – 312Combined sources3
Helixi314 – 326Combined sources13
Helixi340 – 345Combined sources6
Beta strandi362 – 366Combined sources5
Helixi371 – 375Combined sources5
Helixi385 – 387Combined sources3
Beta strandi388 – 390Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DFHX-ray2.20A/B/C2-385[»]
3R25X-ray1.60A/B/C/D/E/F/G/H1-399[»]
3SBFX-ray1.50A/B/C/D2-399[»]
ProteinModelPortaliA5KUH4.
SMRiA5KUH4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA5KUH4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXK. Bacteria.
COG4948. LUCA.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 2 hits.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5KUH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKETIISDIH CIITKPDRHN LITVVVETNE GVTGFGCATF QQRPLAVKTM
60 70 80 90 100
VDEYLKPILI GKNANNIEDL WQMMMVNAYW RNGPVINNAI SGVDMALWDI
110 120 130 140 150
KAKLAGMPLH QLFGGKSRDA IPVYTHATSD TMEGIYDLVE GFLEKGYKHI
160 170 180 190 200
RCQLGFYGGV PTDLHTTQNP TEGSYYDQDQ YMDNTLTMFK SLREKYGNQF
210 220 230 240 250
HILHDVHERL FPNQAIQFAK EVEQYKPYFI EDILPPNQTE WLDNIRSQSS
260 270 280 290 300
VSLGLGELFN NPEEWKSLIA NRRIDFIRCH VSQIGGITPA LKLGHLCQNF
310 320 330 340 350
GVRIAWHCPP DMTPIGAAVN THLNVHLHNA AIQEHVEYNG NTHKVFPNAA
360 370 380 390
EPINGYLYAS EIAGIGVEID REAAAEFPVM YRPHEWTQSR LPDGAIHTP
Length:399
Mass (Da):45,153
Last modified:July 10, 2007 - v1
Checksum:i1CD1514E2F563701
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAZW01000001 Genomic DNA. Translation: EDK31132.1.
RefSeqiWP_008216050.1. NZ_AAZW01000001.1.

Genome annotation databases

EnsemblBacteriaiEDK31132; EDK31132; VSWAT3_13707.
PATRICi25660230. VBIVibBac109234_0307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAZW01000001 Genomic DNA. Translation: EDK31132.1.
RefSeqiWP_008216050.1. NZ_AAZW01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DFHX-ray2.20A/B/C2-385[»]
3R25X-ray1.60A/B/C/D/E/F/G/H1-399[»]
3SBFX-ray1.50A/B/C/D2-399[»]
ProteinModelPortaliA5KUH4.
SMRiA5KUH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391574.VSWAT3_13707.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEDK31132; EDK31132; VSWAT3_13707.
PATRICi25660230. VBIVibBac109234_0307.

Phylogenomic databases

eggNOGiENOG4105CXK. Bacteria.
COG4948. LUCA.

Enzyme and pathway databases

BioCyciVBAC391574:G12RR-310-MONOMER.

Miscellaneous databases

EvolutionaryTraceiA5KUH4.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 2 hits.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMAND_VIBBS
AccessioniPrimary (citable) accession number: A5KUH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 10, 2007
Last modified: November 2, 2016
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.