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Protein

D-galactonate dehydratase family member VSWAT3_13707

Gene

VSWAT3_13707

Organism
Vibrionales bacterium (strain SWAT-3)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has no detectable activity with D-mannonate and with a panel of 70 other acid sugars (in vitro), in spite of the conservation of the residues that are expected to be important for catalytic activity and cofactor binding. May have evolved a divergent function.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi205 – 2051Magnesium1 Publication
Binding sitei207 – 2071Sugar ester
Metal bindingi231 – 2311Magnesium1 Publication
Metal bindingi257 – 2571Magnesium1 Publication
Binding sitei257 – 2571Sugar ester
Binding sitei278 – 2781Sugar ester
Binding sitei307 – 3071Sugar ester
Binding sitei334 – 3341Sugar ester

GO - Molecular functioni

  • catalytic activity Source: InterPro
  • magnesium ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
D-galactonate dehydratase family member VSWAT3_13707
Gene namesi
ORF Names:VSWAT3_13707
OrganismiVibrionales bacterium (strain SWAT-3)
Taxonomic identifieri391574 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesunclassified Vibrionales
Proteomesi
  • UP000004912 Componenti: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 399399D-galactonate dehydratase family member VSWAT3_13707PRO_0000429917Add
BLAST

Interactioni

Subunit structurei

Homotetramer.1 Publication

Protein-protein interaction databases

STRINGi391574.VSWAT3_13707.

Structurei

Secondary structure

1
399
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 1410Combined sources
Beta strandi16 – 194Combined sources
Beta strandi21 – 288Combined sources
Beta strandi33 – 375Combined sources
Helixi44 – 5310Combined sources
Helixi55 – 595Combined sources
Helixi67 – 7610Combined sources
Helixi84 – 10522Combined sources
Helixi109 – 1135Combined sources
Beta strandi117 – 13115Combined sources
Helixi132 – 14413Combined sources
Beta strandi149 – 1557Combined sources
Helixi157 – 1593Combined sources
Helixi161 – 1633Combined sources
Beta strandi172 – 1754Combined sources
Helixi178 – 19619Combined sources
Beta strandi199 – 2057Combined sources
Helixi212 – 22211Combined sources
Helixi223 – 2253Combined sources
Beta strandi228 – 2314Combined sources
Helixi239 – 2413Combined sources
Helixi242 – 2465Combined sources
Beta strandi253 – 2553Combined sources
Helixi262 – 2709Combined sources
Beta strandi275 – 2773Combined sources
Helixi281 – 2844Combined sources
Helixi287 – 30014Combined sources
Beta strandi310 – 3123Combined sources
Helixi314 – 32613Combined sources
Helixi340 – 3456Combined sources
Beta strandi362 – 3665Combined sources
Helixi371 – 3755Combined sources
Helixi385 – 3873Combined sources
Beta strandi388 – 3903Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DFHX-ray2.20A/B/C2-385[»]
3R25X-ray1.60A/B/C/D/E/F/G/H1-399[»]
3SBFX-ray1.50A/B/C/D2-399[»]
ProteinModelPortaliA5KUH4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiA5KUH4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CXK. Bacteria.
COG4948. LUCA.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 2 hits.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5KUH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKETIISDIH CIITKPDRHN LITVVVETNE GVTGFGCATF QQRPLAVKTM
60 70 80 90 100
VDEYLKPILI GKNANNIEDL WQMMMVNAYW RNGPVINNAI SGVDMALWDI
110 120 130 140 150
KAKLAGMPLH QLFGGKSRDA IPVYTHATSD TMEGIYDLVE GFLEKGYKHI
160 170 180 190 200
RCQLGFYGGV PTDLHTTQNP TEGSYYDQDQ YMDNTLTMFK SLREKYGNQF
210 220 230 240 250
HILHDVHERL FPNQAIQFAK EVEQYKPYFI EDILPPNQTE WLDNIRSQSS
260 270 280 290 300
VSLGLGELFN NPEEWKSLIA NRRIDFIRCH VSQIGGITPA LKLGHLCQNF
310 320 330 340 350
GVRIAWHCPP DMTPIGAAVN THLNVHLHNA AIQEHVEYNG NTHKVFPNAA
360 370 380 390
EPINGYLYAS EIAGIGVEID REAAAEFPVM YRPHEWTQSR LPDGAIHTP
Length:399
Mass (Da):45,153
Last modified:July 10, 2007 - v1
Checksum:i1CD1514E2F563701
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAZW01000001 Genomic DNA. Translation: EDK31132.1.
RefSeqiWP_008216050.1. NZ_AAZW01000001.1.

Genome annotation databases

EnsemblBacteriaiEDK31132; EDK31132; VSWAT3_13707.
PATRICi25660230. VBIVibBac109234_0307.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAZW01000001 Genomic DNA. Translation: EDK31132.1.
RefSeqiWP_008216050.1. NZ_AAZW01000001.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DFHX-ray2.20A/B/C2-385[»]
3R25X-ray1.60A/B/C/D/E/F/G/H1-399[»]
3SBFX-ray1.50A/B/C/D2-399[»]
ProteinModelPortaliA5KUH4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi391574.VSWAT3_13707.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiEDK31132; EDK31132; VSWAT3_13707.
PATRICi25660230. VBIVibBac109234_0307.

Phylogenomic databases

eggNOGiENOG4105CXK. Bacteria.
COG4948. LUCA.

Miscellaneous databases

EvolutionaryTraceiA5KUH4.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR018110. Mandel_Rmase/mucon_lact_enz_CS.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 2 hits.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
PROSITEiPS00908. MR_MLE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIMAND_VIBBS
AccessioniPrimary (citable) accession number: A5KUH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 9, 2014
Last sequence update: July 10, 2007
Last modified: January 20, 2016
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.