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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Gene

PVX_111005

Organism
Plasmodium vivax (strain Salvador I)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (PVX_111005), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (PVX_123345)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport, Tricarboxylic acid cycleUniRule annotation
LigandFADUniRule annotation, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:PVX_111005Imported
OrganismiPlasmodium vivax (strain Salvador I)Imported
Taxonomic identifieri126793 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Plasmodium)
Proteomesi
  • UP000008333 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiPlasmoDB:PVX_111005

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

MembraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi5855.PVX_111005

Structurei

3D structure databases

ProteinModelPortaliA5KDV6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 441FAD_binding_2InterPro annotationAdd BLAST406
Domaini496 – 633Succ_DH_flav_CInterPro annotationAdd BLAST138

Sequence similaritiesi

Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

HOGENOMiHOG000160475
InParanoidiA5KDV6
KOiK00234
OMAiGDSPWEH

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

A5KDV6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTVRRKCSP AFALSTRLNF SSVKKKAYDI VDHHYDAVIV GAGGAGLRSG
60 70 80 90 100
LELSKNNYKV ACISKLFPTR SHTVAAQGGI NAALGNMTED DWRWHAYDTI
110 120 130 140 150
KGSDWLGDQN AIQYMCREAP ESVLELEEFG LPFSRTKSGK IYQRAFGGQS
160 170 180 190 200
LKYGKGGQAY RCAAAADRTG HAMLHTLYGQ SLAYNCVFFV EYFVLDLLMA
210 220 230 240 250
SQNECIGVIC LNIADGKIHR FFAPHTVIAT GGYGRAYLSC TSAHACTGDG
260 270 280 290 300
NAIVSRSKLP LQDLEFVQFH PTGIYPAGCL ITEGCRGEGG ILRNREGEAF
310 320 330 340 350
MMRYAPKAKD LASRDVVSRA MTIEINEGRG CGPNADHIYL DLTHLPYETL
360 370 380 390 400
KERLPGIMET AKIFAGVNVT NQYIPVLPTV HYNMGGIPTN YKTQVLTQRV
410 420 430 440 450
NSSKGVSTLE GEDIIVKGLY AAGEAASASV HGANRLGANS LLDIVVFGKR
460 470 480 490 500
ASLTIMEIDK PNIPPISAQA DIGDETIQRL DKIRYNKGTI STAQIRKKMQ
510 520 530 540 550
VCMQKHAAVF RIGPLLEEGY KQILTICSQF NDVYVKDKTL TWNTDLIETL
560 570 580 590 600
ELENLLTLAS QTILAAIERK ESRGAHARDD FPERDDKAFL KHSLTWMTDR
610 620 630
DVEKAKFFTT YRGVITKPLD DEMEHVPPVK RVY
Length:633
Mass (Da):69,980
Last modified:July 10, 2007 - v1
Checksum:i843AA07D4B27E9F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKM01002769 Genomic DNA Translation: EDL42402.1
RefSeqiXP_001608426.1, XM_001608376.1

Genome annotation databases

EnsemblProtistsiEDL42402; EDL42402; PVX_111005
GeneIDi5471444
KEGGipvx:PVX_111005

Similar proteinsi

Entry informationi

Entry nameiA5KDV6_PLAVS
AccessioniPrimary (citable) accession number: A5KDV6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health