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A5K883

- LIPA_PLAVS

UniProt

A5K883 - LIPA_PLAVS

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Protein
Lipoyl synthase, apicoplast
Gene
lipA, PVX_083125
Organism
Plasmodium vivax (strain Salvador I)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives By similarity.UniRule annotation

Catalytic activityi

Protein N(6)-(octanoyl)lysine + 2 sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine.UniRule annotation

Cofactori

Binds 2 4Fe-4S clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi177 – 1771Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi182 – 1821Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi188 – 1881Iron-sulfur 1 (4Fe-4S) By similarity
Metal bindingi203 – 2031Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi207 – 2071Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity
Metal bindingi210 – 2101Iron-sulfur 2 (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-HAMAP
  2. lipoate synthase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. protein lipoylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

UniPathwayiUPA00538; UER00593.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipoyl synthase, apicoplast (EC:2.8.1.8)
Alternative name(s):
Lipoate synthase
Short name:
LS
Short name:
Lip-syn
Lipoic acid synthase
Gene namesi
Name:lipA
ORF Names:PVX_083125
OrganismiPlasmodium vivax (strain Salvador I)
Taxonomic identifieri126793 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Plasmodium)
ProteomesiUP000008333: Chromosome 12, UP000008333: Unassembled WGS sequence

Organism-specific databases

EuPathDBiPlasmoDB:PVX_083125.

Subcellular locationi

Plastidapicoplast By similarity UniRule annotation

GO - Cellular componenti

  1. apicoplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Apicoplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 442417Lipoyl synthase, apicoplastUniRule annotation
PRO_0000398232Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5855.PVX_083125.

Structurei

3D structure databases

ProteinModelPortaliA5K883.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0320.
HOGENOMiHOG000235998.
KOiK03644.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00206. Lipoyl_synth.
InterProiIPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view]
PANTHERiPTHR10949. PTHR10949. 1 hit.
PfamiPF04055. Radical_SAM. 1 hit.
[Graphical view]
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00510. lipA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

A5K883-1 [UniParc]FASTAAdd to Basket

« Hide

MHVLTPSLYI YAFFIVCVRL KCGRSKRVAN AKHATYDMPP KGLRVRDMLE    50
KTAQQNCNQR KRGKCRKFFF LWKMDKMGDT HLGGQANGRK NLLRSESATD 100
EASLGGNPLK EKLKESPANW GKDKQEEQQS TDRLPLPKVG NKMPEKKPDW 150
FHVPAPTGKK YNELKADLKK LKLHTVCEEA QCPNIGECWN IGTATIMLLG 200
DTCTRGCKFC SIKTSSKPLP PDANEPFNTA KAICEWDINY VVLTSVDRDD 250
LPDGGASHFA KTIELIKFSR PEILIECLVS DFQGNVDSIR KLANSGMEVY 300
AHNIETVRRL QKFVRDRRAN YEQSLWVLKT AKEINPLLYT KTSIMLGLGE 350
TKQEVLQAMA DVRQNNIDVI TFGQYLRPTK NHLNVVEYVS PQMFDYYKEE 400
GMKMGFKYIA SGPLVRSSYK AGEYFMKNLV EQRRGVKLHA EG 442
Length:442
Mass (Da):50,317
Last modified:July 10, 2007 - v1
Checksum:i0EFA968BB12F4E3F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAKM01000009 Genomic DNA. Translation: EDL44497.1.
RefSeqiXP_001614224.1. XM_001614174.1.

Genome annotation databases

GeneIDi5473509.
KEGGipvx:PVX_083125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAKM01000009 Genomic DNA. Translation: EDL44497.1 .
RefSeqi XP_001614224.1. XM_001614174.1.

3D structure databases

ProteinModelPortali A5K883.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5855.PVX_083125.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5473509.
KEGGi pvx:PVX_083125.

Organism-specific databases

EuPathDBi PlasmoDB:PVX_083125.

Phylogenomic databases

eggNOGi COG0320.
HOGENOMi HOG000235998.
KOi K03644.

Enzyme and pathway databases

UniPathwayi UPA00538 ; UER00593 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00206. Lipoyl_synth.
InterProi IPR013785. Aldolase_TIM.
IPR006638. Elp3/MiaB/NifB.
IPR003698. Lipoyl_synth.
IPR007197. rSAM.
[Graphical view ]
PANTHERi PTHR10949. PTHR10949. 1 hit.
Pfami PF04055. Radical_SAM. 1 hit.
[Graphical view ]
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00510. lipA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Salvador I.

Entry informationi

Entry nameiLIPA_PLAVS
AccessioniPrimary (citable) accession number: A5K883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: July 10, 2007
Last modified: June 11, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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