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A5K1A2

- A5K1A2_PLAVS

UniProt

A5K1A2 - A5K1A2_PLAVS

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Protein
Glycylpeptide N-tetradecanoyltransferase
Gene
PVX_085815
Organism
Plasmodium vivax (strain Salvador I)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins By similarity.UniRule annotation

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei180 – 1801Chloride 1Imported
Binding sitei210 – 2101Sulfate 1Imported
Binding sitei210 – 2101Sulfate 2
Binding sitei210 – 2101Sulfate 3Imported
Binding sitei248 – 2481Chloride 2; via amide nitrogenImported
Binding sitei358 – 3581Chloride 2Imported
Binding sitei373 – 3731Sulfate 1Imported
Binding sitei373 – 3731Sulfate 3Imported

GO - Molecular functioni

  1. glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. N-terminal protein myristoylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferaseUniRule annotation (EC:2.3.1.97UniRule annotation)
Gene namesi
ORF Names:PVX_085815Imported
OrganismiPlasmodium vivax (strain Salvador I)
Taxonomic identifieri126793 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Plasmodium)
ProteomesiUP000008333: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PVX_085815.

Interactioni

Protein-protein interaction databases

STRINGi5855.PVX_085815.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YNCX-ray1.75A/B/C27-410[»]
2YNDX-ray1.89A/B/C26-410[»]
2YNEX-ray1.72A/B/C27-410[»]
4A95X-ray1.55A/B/C27-410[»]
4B10X-ray1.56A/B/C27-410[»]
4B11X-ray1.59A/B/C27-410[»]
4B12X-ray1.79A/B/C27-410[»]
4B13X-ray1.58A/B/C27-410[»]
4B14X-ray1.50A/B/C27-410[»]
4BBHX-ray1.63A/B/C27-410[»]
4CAEX-ray1.46A/B/C27-410[»]
4CAFX-ray1.70A/B/C27-410[»]
ProteinModelPortaliA5K1A2.
SMRiA5K1A2. Positions 70-409.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni328 – 3292Chloride 3 bindingImported

Sequence similaritiesi

Belongs to the NMT family.

Phylogenomic databases

HOGENOMiHOG000189123.
KOiK00671.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5K1A2-1 [UniParc]FASTAAdd to Basket

« Hide

MNDDNKEFSG RDIYQLIKNA KDKIKIDYKF WYTQPVPKIN DEFNESVNEP    50
FISDNKVEDV RKDEYKLPPG YSWYVCDVKD EKDRSEIYTL LTDNYVEDDD 100
NIFRFNYSAE FLLWALTSPN YLKTWHIGVK YDASNKLIGF ISAIPTDICI 150
HKRTIKMAEV NFLCVHKTLR SKRLAPVLIK EITRRINLEN IWQAIYTAGV 200
YLPKPVSDAR YYHRSINVKK LIEIGFSSLN SRLTMSRAIK LYRVEDTLNI 250
KNMRLMKKKD VEGVHKLLGS YLEQFNLYAV FTKEEIAHWF LPIENVIYTY 300
VNEENGKIKD MISFYSLPSQ ILGNDKYSTL NAAYSFYNVT TTATFKQLMQ 350
DAILLAKRNN FDVFNALEVM QNKSVFEDLK FGEGDGSLKY YLYNWKCASF 400
APAHVGIVLL 410
Length:410
Mass (Da):47,970
Last modified:July 10, 2007 - v1
Checksum:i86D56189E9852475
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAKM01000002 Genomic DNA. Translation: EDL47099.1.
RefSeqiXP_001616826.1. XM_001616776.1.

Genome annotation databases

GeneIDi5476134.
KEGGipvx:PVX_085815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAKM01000002 Genomic DNA. Translation: EDL47099.1 .
RefSeqi XP_001616826.1. XM_001616776.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2YNC X-ray 1.75 A/B/C 27-410 [» ]
2YND X-ray 1.89 A/B/C 26-410 [» ]
2YNE X-ray 1.72 A/B/C 27-410 [» ]
4A95 X-ray 1.55 A/B/C 27-410 [» ]
4B10 X-ray 1.56 A/B/C 27-410 [» ]
4B11 X-ray 1.59 A/B/C 27-410 [» ]
4B12 X-ray 1.79 A/B/C 27-410 [» ]
4B13 X-ray 1.58 A/B/C 27-410 [» ]
4B14 X-ray 1.50 A/B/C 27-410 [» ]
4BBH X-ray 1.63 A/B/C 27-410 [» ]
4CAE X-ray 1.46 A/B/C 27-410 [» ]
4CAF X-ray 1.70 A/B/C 27-410 [» ]
ProteinModelPortali A5K1A2.
SMRi A5K1A2. Positions 70-409.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5855.PVX_085815.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5476134.
KEGGi pvx:PVX_085815.

Organism-specific databases

EuPathDBi PlasmoDB:PVX_085815.

Phylogenomic databases

HOGENOMi HOG000189123.
KOi K00671.

Family and domain databases

Gene3Di 3.40.630.30. 2 hits.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view ]
PANTHERi PTHR11377. PTHR11377. 1 hit.
Pfami PF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF015892. N-myristl_transf. 1 hit.
SUPFAMi SSF55729. SSF55729. 2 hits.
PROSITEi PS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Salvador IImported.
  2. "Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode."
    Goncalves V., Brannigan J.A., Whalley D., Ansell K.H., Saxty B., Holder A.A., Wilkinson A.J., Tate E.W., Leatherbarrow R.J.
    J. Med. Chem. 55:3578-3582(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 27-410.
  3. "Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery."
    Yu Z., Brannigan J.A., Moss D.K., Brzozowski A.M., Wilkinson A.J., Holder A.A., Tate E.W., Leatherbarrow R.J.
    J. Med. Chem. 55:8879-8890(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 27-410.
  4. "Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase."
    Rackham M.D., Brannigan J.A., Moss D.K., Yu Z., Wilkinson A.J., Holder A.A., Tate E.W., Leatherbarrow R.J.
    J. Med. Chem. 56:371-375(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 27-410.
  5. "Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP)."
    Rackham M.D., Brannigan J.A., Rangachari K., Meister S., Wilkinson A.J., Holder A.A., Leatherbarrow R.J., Tate E.W.
    J. Med. Chem. 57:2773-2788(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 27-410.
  6. "Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach."
    Wright M.H., Clough B., Rackham M.D., Rangachari K., Brannigan J.A., Grainger M., Moss D.K., Bottrill A.R., Heal W.P., Broncel M., Serwa R.A., Brady D., Mann D.J., Leatherbarrow R.J., Tewari R., Wilkinson A.J., Holder A.A., Tate E.W.
    Nat. Chem. 6:112-121(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 27-410.

Entry informationi

Entry nameiA5K1A2_PLAVS
AccessioniPrimary (citable) accession number: A5K1A2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: September 3, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteome

External Data

Dasty 3

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