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A5K1A2

- A5K1A2_PLAVS

UniProt

A5K1A2 - A5K1A2_PLAVS

Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

PVX_085815

Organism
Plasmodium vivax (strain Salvador I)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (10 Jul 2007)
      Previous versions | rss
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    Functioni

    Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.UniRule annotation

    Catalytic activityi

    Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei180 – 1801Chloride 1Imported
    Binding sitei210 – 2101Sulfate 1Imported
    Binding sitei210 – 2101Sulfate 2
    Binding sitei210 – 2101Sulfate 3Imported
    Binding sitei248 – 2481Chloride 2; via amide nitrogenImported
    Binding sitei358 – 3581Chloride 2Imported
    Binding sitei373 – 3731Sulfate 1Imported
    Binding sitei373 – 3731Sulfate 3Imported

    GO - Molecular functioni

    1. glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. N-terminal protein myristoylation Source: InterPro

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotation, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycylpeptide N-tetradecanoyltransferaseUniRule annotation (EC:2.3.1.97UniRule annotation)
    Gene namesi
    ORF Names:PVX_085815Imported
    OrganismiPlasmodium vivax (strain Salvador I)Imported
    Taxonomic identifieri126793 [NCBI]
    Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Plasmodium)
    ProteomesiUP000008333: Chromosome 13

    Organism-specific databases

    EuPathDBiPlasmoDB:PVX_085815.

    Interactioni

    Protein-protein interaction databases

    STRINGi5855.PVX_085815.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2YNCX-ray1.75A/B/C27-410[»]
    2YNDX-ray1.89A/B/C26-410[»]
    2YNEX-ray1.72A/B/C27-410[»]
    4A95X-ray1.55A/B/C27-410[»]
    4B10X-ray1.56A/B/C27-410[»]
    4B11X-ray1.59A/B/C27-410[»]
    4B12X-ray1.79A/B/C27-410[»]
    4B13X-ray1.58A/B/C27-410[»]
    4B14X-ray1.50A/B/C27-410[»]
    4BBHX-ray1.63A/B/C27-410[»]
    4CAEX-ray1.46A/B/C27-410[»]
    4CAFX-ray1.70A/B/C27-410[»]
    ProteinModelPortaliA5K1A2.
    SMRiA5K1A2. Positions 70-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni328 – 3292Chloride 3 bindingImported

    Sequence similaritiesi

    Belongs to the NMT family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000189123.
    KOiK00671.

    Family and domain databases

    Gene3Di3.40.630.30. 2 hits.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000903. MyristoylCoA_TrFase.
    IPR022677. MyristoylCoA_TrFase_C.
    IPR022678. MyristoylCoA_TrFase_CS.
    IPR022676. MyristoylCoA_TrFase_N.
    [Graphical view]
    PANTHERiPTHR11377. PTHR11377. 1 hit.
    PfamiPF01233. NMT. 1 hit.
    PF02799. NMT_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
    SUPFAMiSSF55729. SSF55729. 2 hits.
    PROSITEiPS00975. NMT_1. 1 hit.
    PS00976. NMT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5K1A2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNDDNKEFSG RDIYQLIKNA KDKIKIDYKF WYTQPVPKIN DEFNESVNEP    50
    FISDNKVEDV RKDEYKLPPG YSWYVCDVKD EKDRSEIYTL LTDNYVEDDD 100
    NIFRFNYSAE FLLWALTSPN YLKTWHIGVK YDASNKLIGF ISAIPTDICI 150
    HKRTIKMAEV NFLCVHKTLR SKRLAPVLIK EITRRINLEN IWQAIYTAGV 200
    YLPKPVSDAR YYHRSINVKK LIEIGFSSLN SRLTMSRAIK LYRVEDTLNI 250
    KNMRLMKKKD VEGVHKLLGS YLEQFNLYAV FTKEEIAHWF LPIENVIYTY 300
    VNEENGKIKD MISFYSLPSQ ILGNDKYSTL NAAYSFYNVT TTATFKQLMQ 350
    DAILLAKRNN FDVFNALEVM QNKSVFEDLK FGEGDGSLKY YLYNWKCASF 400
    APAHVGIVLL 410
    Length:410
    Mass (Da):47,970
    Last modified:July 10, 2007 - v1
    Checksum:i86D56189E9852475
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAKM01000002 Genomic DNA. Translation: EDL47099.1.
    RefSeqiXP_001616826.1. XM_001616776.1.

    Genome annotation databases

    GeneIDi5476134.
    KEGGipvx:PVX_085815.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAKM01000002 Genomic DNA. Translation: EDL47099.1 .
    RefSeqi XP_001616826.1. XM_001616776.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2YNC X-ray 1.75 A/B/C 27-410 [» ]
    2YND X-ray 1.89 A/B/C 26-410 [» ]
    2YNE X-ray 1.72 A/B/C 27-410 [» ]
    4A95 X-ray 1.55 A/B/C 27-410 [» ]
    4B10 X-ray 1.56 A/B/C 27-410 [» ]
    4B11 X-ray 1.59 A/B/C 27-410 [» ]
    4B12 X-ray 1.79 A/B/C 27-410 [» ]
    4B13 X-ray 1.58 A/B/C 27-410 [» ]
    4B14 X-ray 1.50 A/B/C 27-410 [» ]
    4BBH X-ray 1.63 A/B/C 27-410 [» ]
    4CAE X-ray 1.46 A/B/C 27-410 [» ]
    4CAF X-ray 1.70 A/B/C 27-410 [» ]
    ProteinModelPortali A5K1A2.
    SMRi A5K1A2. Positions 70-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5855.PVX_085815.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5476134.
    KEGGi pvx:PVX_085815.

    Organism-specific databases

    EuPathDBi PlasmoDB:PVX_085815.

    Phylogenomic databases

    HOGENOMi HOG000189123.
    KOi K00671.

    Family and domain databases

    Gene3Di 3.40.630.30. 2 hits.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000903. MyristoylCoA_TrFase.
    IPR022677. MyristoylCoA_TrFase_C.
    IPR022678. MyristoylCoA_TrFase_CS.
    IPR022676. MyristoylCoA_TrFase_N.
    [Graphical view ]
    PANTHERi PTHR11377. PTHR11377. 1 hit.
    Pfami PF01233. NMT. 1 hit.
    PF02799. NMT_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015892. N-myristl_transf. 1 hit.
    SUPFAMi SSF55729. SSF55729. 2 hits.
    PROSITEi PS00975. NMT_1. 1 hit.
    PS00976. NMT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Salvador IImported.
    2. "Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode."
      Goncalves V., Brannigan J.A., Whalley D., Ansell K.H., Saxty B., Holder A.A., Wilkinson A.J., Tate E.W., Leatherbarrow R.J.
      J. Med. Chem. 55:3578-3582(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 27-410.
    3. "Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery."
      Yu Z., Brannigan J.A., Moss D.K., Brzozowski A.M., Wilkinson A.J., Holder A.A., Tate E.W., Leatherbarrow R.J.
      J. Med. Chem. 55:8879-8890(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 27-410.
    4. "Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase."
      Rackham M.D., Brannigan J.A., Moss D.K., Yu Z., Wilkinson A.J., Holder A.A., Tate E.W., Leatherbarrow R.J.
      J. Med. Chem. 56:371-375(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 27-410.
    5. "Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP)."
      Rackham M.D., Brannigan J.A., Rangachari K., Meister S., Wilkinson A.J., Holder A.A., Leatherbarrow R.J., Tate E.W.
      J. Med. Chem. 57:2773-2788(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 27-410.
    6. "Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach."
      Wright M.H., Clough B., Rackham M.D., Rangachari K., Brannigan J.A., Grainger M., Moss D.K., Bottrill A.R., Heal W.P., Broncel M., Serwa R.A., Brady D., Mann D.J., Leatherbarrow R.J., Tewari R., Wilkinson A.J., Holder A.A., Tate E.W.
      Nat. Chem. 6:112-121(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 27-410.

    Entry informationi

    Entry nameiA5K1A2_PLAVS
    AccessioniPrimary (citable) accession number: A5K1A2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 10, 2007
    Last sequence update: July 10, 2007
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3