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Protein

Glycylpeptide N-tetradecanoyltransferase

Gene

PVX_085815

Organism
Plasmodium vivax (strain Salvador I)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.UniRule annotation

Catalytic activityi

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide.UniRule annotation

GO - Molecular functioni

  1. glycylpeptide N-tetradecanoyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. N-terminal protein myristoylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glycylpeptide N-tetradecanoyltransferaseUniRule annotation (EC:2.3.1.97UniRule annotation)
Gene namesi
ORF Names:PVX_085815Imported
OrganismiPlasmodium vivax (strain Salvador I)Imported
Taxonomic identifieri126793 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Plasmodium)
ProteomesiUP000008333 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PVX_085815.

Interactioni

Protein-protein interaction databases

STRINGi5855.PVX_085815.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YNCX-ray1.75A/B/C27-410[»]
2YNDX-ray1.89A/B/C26-410[»]
2YNEX-ray1.72A/B/C27-410[»]
4A95X-ray1.55A/B/C27-410[»]
4B10X-ray1.56A/B/C27-410[»]
4B11X-ray1.59A/B/C27-410[»]
4B12X-ray1.79A/B/C27-410[»]
4B13X-ray1.58A/B/C27-410[»]
4B14X-ray1.50A/B/C27-410[»]
4BBHX-ray1.63A/B/C27-410[»]
4C68X-ray1.38A/B/C27-410[»]
4CAEX-ray1.46A/B/C27-410[»]
4CAFX-ray1.70A/B/C27-410[»]
ProteinModelPortaliA5K1A2.
SMRiA5K1A2. Positions 70-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NMT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000189123.
InParanoidiA5K1A2.
KOiK00671.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5K1A2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNDDNKEFSG RDIYQLIKNA KDKIKIDYKF WYTQPVPKIN DEFNESVNEP
60 70 80 90 100
FISDNKVEDV RKDEYKLPPG YSWYVCDVKD EKDRSEIYTL LTDNYVEDDD
110 120 130 140 150
NIFRFNYSAE FLLWALTSPN YLKTWHIGVK YDASNKLIGF ISAIPTDICI
160 170 180 190 200
HKRTIKMAEV NFLCVHKTLR SKRLAPVLIK EITRRINLEN IWQAIYTAGV
210 220 230 240 250
YLPKPVSDAR YYHRSINVKK LIEIGFSSLN SRLTMSRAIK LYRVEDTLNI
260 270 280 290 300
KNMRLMKKKD VEGVHKLLGS YLEQFNLYAV FTKEEIAHWF LPIENVIYTY
310 320 330 340 350
VNEENGKIKD MISFYSLPSQ ILGNDKYSTL NAAYSFYNVT TTATFKQLMQ
360 370 380 390 400
DAILLAKRNN FDVFNALEVM QNKSVFEDLK FGEGDGSLKY YLYNWKCASF
410
APAHVGIVLL
Length:410
Mass (Da):47,970
Last modified:July 9, 2007 - v1
Checksum:i86D56189E9852475
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKM01000002 Genomic DNA. Translation: EDL47099.1.
RefSeqiXP_001616826.1. XM_001616776.1.

Genome annotation databases

GeneIDi5476134.
KEGGipvx:PVX_085815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKM01000002 Genomic DNA. Translation: EDL47099.1.
RefSeqiXP_001616826.1. XM_001616776.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2YNCX-ray1.75A/B/C27-410[»]
2YNDX-ray1.89A/B/C26-410[»]
2YNEX-ray1.72A/B/C27-410[»]
4A95X-ray1.55A/B/C27-410[»]
4B10X-ray1.56A/B/C27-410[»]
4B11X-ray1.59A/B/C27-410[»]
4B12X-ray1.79A/B/C27-410[»]
4B13X-ray1.58A/B/C27-410[»]
4B14X-ray1.50A/B/C27-410[»]
4BBHX-ray1.63A/B/C27-410[»]
4C68X-ray1.38A/B/C27-410[»]
4CAEX-ray1.46A/B/C27-410[»]
4CAFX-ray1.70A/B/C27-410[»]
ProteinModelPortaliA5K1A2.
SMRiA5K1A2. Positions 70-409.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5855.PVX_085815.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5476134.
KEGGipvx:PVX_085815.

Organism-specific databases

EuPathDBiPlasmoDB:PVX_085815.

Phylogenomic databases

HOGENOMiHOG000189123.
InParanoidiA5K1A2.
KOiK00671.

Family and domain databases

Gene3Di3.40.630.30. 2 hits.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERiPTHR11377. PTHR11377. 1 hit.
PfamiPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFiPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMiSSF55729. SSF55729. 2 hits.
PROSITEiPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Salvador IImported.
  2. "Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode."
    Goncalves V., Brannigan J.A., Whalley D., Ansell K.H., Saxty B., Holder A.A., Wilkinson A.J., Tate E.W., Leatherbarrow R.J.
    J. Med. Chem. 55:3578-3582(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 27-410.
  3. "Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery."
    Yu Z., Brannigan J.A., Moss D.K., Brzozowski A.M., Wilkinson A.J., Holder A.A., Tate E.W., Leatherbarrow R.J.
    J. Med. Chem. 55:8879-8890(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 27-410.
  4. "Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase."
    Rackham M.D., Brannigan J.A., Moss D.K., Yu Z., Wilkinson A.J., Holder A.A., Tate E.W., Leatherbarrow R.J.
    J. Med. Chem. 56:371-375(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 27-410.
  5. "Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP)."
    Rackham M.D., Brannigan J.A., Rangachari K., Meister S., Wilkinson A.J., Holder A.A., Leatherbarrow R.J., Tate E.W.
    J. Med. Chem. 57:2773-2788(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 27-410.
  6. "Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach."
    Wright M.H., Clough B., Rackham M.D., Rangachari K., Brannigan J.A., Grainger M., Moss D.K., Bottrill A.R., Heal W.P., Broncel M., Serwa R.A., Brady D., Mann D.J., Leatherbarrow R.J., Tewari R., Wilkinson A.J., Holder A.A., Tate E.W.
    Nat. Chem. 6:112-121(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 27-410.
  7. "Peptidomimetic inhibitors of N-myristoyltransferase from human malaria and leishmaniasis parasites."
    Olaleye T.O., Brannigan J.A., Roberts S.M., Leatherbarrow R.J., Wilkinson A.J., Tate E.W.
    Org. Biomol. Chem. 12:8132-8137(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS) OF 27-410.

Entry informationi

Entry nameiA5K1A2_PLAVS
AccessioniPrimary (citable) accession number: A5K1A2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 9, 2007
Last sequence update: July 9, 2007
Last modified: January 6, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.