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A5K1A2 (A5K1A2_PLAVS) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Glycylpeptide N-tetradecanoyltransferase RuleBase RU000586

EC=2.3.1.97 RuleBase RU000586
Gene names
ORF Names:PVX_085815 EMBL EDL47099.1
OrganismPlasmodium vivax (strain Salvador I) [Reference proteome]
Taxonomic identifier126793 [NCBI]
Taxonomic lineageEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiumPlasmodium (Plasmodium)

Protein attributes

Sequence length410 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins By similarity. RuleBase RU000586

Catalytic activity

Tetradecanoyl-CoA + glycylpeptide = CoA + N-tetradecanoylglycylpeptide. RuleBase RU000586

Sequence similarities

Belongs to the NMT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region328 – 3292Chloride 3 binding PDB 2YNE PDB 4CAE

Sites

Binding site1801Chloride 1 PDB 4B10 PDB 4B11 PDB 4B14 PDB 4CAE PDB 4CAF
Binding site2101Sulfate 1 PDB 4B10 PDB 4B13 PDB 4B14 PDB 4BBH PDB 2YND PDB 4CAE PDB 4CAF
Binding site2101Sulfate 2
Binding site2101Sulfate 3 PDB 4B11
Binding site2481Chloride 2; via amide nitrogen PDB 2YNC
Binding site3581Chloride 2 PDB 2YNC
Binding site3731Sulfate 1 PDB 4B13 PDB 4B14 PDB 4BBH PDB 2YND
Binding site3731Sulfate 3 PDB 4B11

Sequences

Sequence LengthMass (Da)Tools
A5K1A2 [UniParc].

Last modified July 10, 2007. Version 1.
Checksum: 86D56189E9852475

FASTA41047,970
        10         20         30         40         50         60 
MNDDNKEFSG RDIYQLIKNA KDKIKIDYKF WYTQPVPKIN DEFNESVNEP FISDNKVEDV 

        70         80         90        100        110        120 
RKDEYKLPPG YSWYVCDVKD EKDRSEIYTL LTDNYVEDDD NIFRFNYSAE FLLWALTSPN 

       130        140        150        160        170        180 
YLKTWHIGVK YDASNKLIGF ISAIPTDICI HKRTIKMAEV NFLCVHKTLR SKRLAPVLIK 

       190        200        210        220        230        240 
EITRRINLEN IWQAIYTAGV YLPKPVSDAR YYHRSINVKK LIEIGFSSLN SRLTMSRAIK 

       250        260        270        280        290        300 
LYRVEDTLNI KNMRLMKKKD VEGVHKLLGS YLEQFNLYAV FTKEEIAHWF LPIENVIYTY 

       310        320        330        340        350        360 
VNEENGKIKD MISFYSLPSQ ILGNDKYSTL NAAYSFYNVT TTATFKQLMQ DAILLAKRNN 

       370        380        390        400        410 
FDVFNALEVM QNKSVFEDLK FGEGDGSLKY YLYNWKCASF APAHVGIVLL 

« Hide

References

« Hide 'large scale' references
[1]"Comparative genomics of the neglected human malaria parasite Plasmodium vivax."
Carlton J.M., Adams J.H., Silva J.C., Bidwell S.L., Lorenzi H., Caler E., Crabtree J., Angiuoli S.V., Merino E.F., Amedeo P., Cheng Q., Coulson R.M.R., Crabb B.S., del Portillo H.A., Essien K., Feldblyum T.V., Fernandez-Becerra C., Gilson P.R. expand/collapse author list , Gueye A.H., Guo X., Kang'a S., Kooij T.W.A., Korsinczky M., Meyer E.V.-S., Nene V., Paulsen I., White O., Ralph S.A., Ren Q., Sargeant T.J., Salzberg S.L., Stoeckert C.J., Sullivan S.A., Yamamoto M.M., Hoffman S.L., Wortman J.R., Gardner M.J., Galinski M.R., Barnwell J.W., Fraser-Liggett C.M.
Nature 455:757-763(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Salvador I EMBL EDL47099.1.
[2]"Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode."
Goncalves V., Brannigan J.A., Whalley D., Ansell K.H., Saxty B., Holder A.A., Wilkinson A.J., Tate E.W., Leatherbarrow R.J.
J. Med. Chem. 55:3578-3582(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 27-410 IN COMPLEX WITH CHLORIDE AND SULFATE.
[3]"Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery."
Yu Z., Brannigan J.A., Moss D.K., Brzozowski A.M., Wilkinson A.J., Holder A.A., Tate E.W., Leatherbarrow R.J.
J. Med. Chem. 55:8879-8890(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 27-410 IN COMPLEX WITH CHLORIDE AND SULFATE.
[4]"Discovery of novel and ligand-efficient inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferase."
Rackham M.D., Brannigan J.A., Moss D.K., Yu Z., Wilkinson A.J., Holder A.A., Tate E.W., Leatherbarrow R.J.
J. Med. Chem. 56:371-375(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 27-410 IN COMPLEX WITH SULFATE.
[5]"Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP)."
Rackham M.D., Brannigan J.A., Rangachari K., Meister S., Wilkinson A.J., Holder A.A., Leatherbarrow R.J., Tate E.W.
J. Med. Chem. 57:2773-2788(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 27-410 IN COMPLEX WITH CHLORIDE AND SULFATE.
[6]"Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach."
Wright M.H., Clough B., Rackham M.D., Rangachari K., Brannigan J.A., Grainger M., Moss D.K., Bottrill A.R., Heal W.P., Broncel M., Serwa R.A., Brady D., Mann D.J., Leatherbarrow R.J., Tewari R., Wilkinson A.J., Holder A.A., Tate E.W.
Nat. Chem. 6:112-121(2014) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.72 ANGSTROMS) OF 27-410 IN COMPLEX WITH CHLORIDE AND SULFATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAKM01000002 Genomic DNA. Translation: EDL47099.1.
RefSeqXP_001616826.1. XM_001616776.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2YNCX-ray1.75A/B/C27-410[»]
2YNDX-ray1.89A/B/C26-410[»]
2YNEX-ray1.72A/B/C27-410[»]
4A95X-ray1.55A/B/C27-410[»]
4B10X-ray1.56A/B/C27-410[»]
4B11X-ray1.59A/B/C27-410[»]
4B12X-ray1.79A/B/C27-410[»]
4B13X-ray1.58A/B/C27-410[»]
4B14X-ray1.50A/B/C27-410[»]
4BBHX-ray1.63A/B/C27-410[»]
4CAEX-ray1.46A/B/C27-410[»]
4CAFX-ray1.70A/B/C27-410[»]
ProteinModelPortalA5K1A2.
SMRA5K1A2. Positions 70-409.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5855.PVX_085815.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5476134.
KEGGpvx:PVX_085815.

Organism-specific databases

EuPathDBPlasmoDB:PVX_085815.

Phylogenomic databases

HOGENOMHOG000189123.
KOK00671.

Family and domain databases

Gene3D3.40.630.30. 2 hits.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000903. MyristoylCoA_TrFase.
IPR022677. MyristoylCoA_TrFase_C.
IPR022678. MyristoylCoA_TrFase_CS.
IPR022676. MyristoylCoA_TrFase_N.
[Graphical view]
PANTHERPTHR11377. PTHR11377. 1 hit.
PfamPF01233. NMT. 1 hit.
PF02799. NMT_C. 1 hit.
[Graphical view]
PIRSFPIRSF015892. N-myristl_transf. 1 hit.
SUPFAMSSF55729. SSF55729. 2 hits.
PROSITEPS00975. NMT_1. 1 hit.
PS00976. NMT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5K1A2_PLAVS
AccessionPrimary (citable) accession number: A5K1A2
Entry history
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: July 9, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)