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Protein
Submitted name:

cGMP-dependent protein kinase, putative

Gene

PVX_084705

Organism
Plasmodium vivax (strain Salvador I)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei563ATPUniRule annotation1
Binding sitei563ATP analogCombined sources1
Binding sitei618ATP analogCombined sources1
Active sitei657Proton acceptorUniRule annotation1
Binding sitei675ATP analogCombined sources1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi612 – 614ATP analogCombined sources3

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseSAAS annotation, Transferase
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
cGMP-dependent protein kinase, putativeImported
Gene namesi
ORF Names:PVX_084705Imported
OrganismiPlasmodium vivax (strain Salvador I)Imported
Taxonomic identifieri126793 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Plasmodium)
Proteomesi
  • UP000008333 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PVX_084705.

Interactioni

Protein-protein interaction databases

STRINGi5855.PVX_084705.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4RZ7X-ray2.35A1-846[»]
5DYLX-ray2.40A1-846[»]
5DZCX-ray2.30A1-846[»]
5EZRX-ray2.50A1-846[»]
5F0AX-ray2.60A1-846[»]
5FETX-ray3.07A1-846[»]
ProteinModelPortaliA5K0N4.
SMRiA5K0N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 166Cyclic nucleotide-bindingInterPro annotationAdd BLAST116
Domaini169 – 268Cyclic nucleotide-bindingInterPro annotationAdd BLAST100
Domaini288 – 391Cyclic nucleotide-bindingInterPro annotationAdd BLAST104
Domaini411 – 510Cyclic nucleotide-bindingInterPro annotationAdd BLAST100
Domaini534 – 791Protein kinaseInterPro annotationAdd BLAST258
Domaini792 – 846AGC-kinase C-terminalInterPro annotationAdd BLAST55

Phylogenomic databases

HOGENOMiHOG000281211.
InParanoidiA5K0N4.
KOiK07376.
OMAiELQSKCI.

Family and domain databases

CDDicd00038. CAP_ED. 3 hits.
cd05572. STKc_cGK. 1 hit.
Gene3Di2.60.120.10. 4 hits.
InterProiView protein in InterPro
IPR000961. AGC-kinase_C.
IPR002374. cGMP_dep_kinase.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom_sf.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR008271. Ser/Thr_kinase_AS.
IPR035014. STKc_cGK.
PfamiView protein in Pfam
PF00027. cNMP_binding. 3 hits.
PF00069. Pkinase. 1 hit.
PIRSFiPIRSF000559. cGMP-dep_kinase. 2 hits.
SMARTiView protein in SMART
SM00100. cNMP. 4 hits.
SM00220. S_TKc. 1 hit.
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 3 hits.
PS00889. CNMP_BINDING_2. 3 hits.
PS50042. CNMP_BINDING_3. 4 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.

Sequencei

Sequence statusi: Complete.

A5K0N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCNERNKKK AIFSNDDFSG EDTLMEDHLQ LREKLSEDIE MIKASLKNNL
60 70 80 90 100
VCSTLNDNEI LTLSNYMQFF VFKGGDLVIK QGEKGSYFFI INSGKFDVYV
110 120 130 140 150
NDKKVKSMGK GSSFGEAALI HNTQRSATIM AETDGTLWGV QRSTFRATLK
160 170 180 190 200
QLSNRNFNEN RSFIDSVSVF DMLTEAQKNM ITNACVIQMF KPGETIVKQG
210 220 230 240 250
DYGDVLFILK EGKATVFIND KEIRVLNKGS YFGERALLYD EPRSATIIAK
260 270 280 290 300
EPTACASICR KLLNIVLGNL QVVLFRNIMT EALQQSEIFR QFSAEQLNDL
310 320 330 340 350
ADTAIVRDYP ANYHILHKDK VKSVKYLIVL EGKVELFLDD ESIGILTRGK
360 370 380 390 400
SFGDQYVLNQ KQKFRHTVKS LDVCKIALIT ESCLADCLGD NNIDASIDHN
410 420 430 440 450
NKKSIIKKMY IFRYLSEQQC NLLIEAFRTT RYEEGDYIIQ EGEVGSRFYI
460 470 480 490 500
IKNGEVEVTK NGKRLRTLGK NDYFGERALL YDEPRTASII SKATSVECWF
510 520 530 540 550
VDKSVFLQII QGPMLTHLEE RIKMQDTKVE MHELETERII GRGTFGTVKL
560 570 580 590 600
VHHKPTQIRY ALKCVSKRSI ISLNQQNNIK LEREITAEND HPFIIRLVRT
610 620 630 640 650
FKDSNCFYFL TELVTGGELY DAIRKLGLLS KPQAQFYLGS IILAIEYLHE
660 670 680 690 700
RNIVYRDLKP ENILLDKQGY VKLIDFGCAK KIQGRAYTLV GTPHYMAPEV
710 720 730 740 750
ILGKGYGCTV DIWALGVCLY EFICGPLPFG NDQEDQLEIF RDILTGQLTF
760 770 780 790 800
PDYVSDQDSI NLMKRLLCRL PQGRIGCSIN GFKDIKEHAF FGNFNWDKLA
810 820 830 840
GRLLEPPLVS KGETYAEDID IKQIEEEDAL NEGEPLDGDD SWDVDF
Length:846
Mass (Da):96,548
Last modified:July 10, 2007 - v1
Checksum:iF4816715FBBB8211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKM01000002 Genomic DNA. Translation: EDL46881.1.
RefSeqiXP_001616608.1. XM_001616558.1.

Genome annotation databases

EnsemblProtistsiEDL46881; EDL46881; PVX_084705.
GeneIDi5475916.
KEGGipvx:PVX_084705.

Similar proteinsi

Entry informationi

Entry nameiA5K0N4_PLAVS
AccessioniPrimary (citable) accession number: A5K0N4
Entry historyiIntegrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: November 22, 2017
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported