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Protein
Submitted name:

cGMP-dependent protein kinase, putative

Gene

PVX_084705

Organism
Plasmodium vivax (strain Salvador I)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
cGMP-dependent protein kinase, putativeImported
Gene namesi
ORF Names:PVX_084705Imported
OrganismiPlasmodium vivax (strain Salvador I)Imported
Taxonomic identifieri126793 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Plasmodium)
Proteomesi
  • UP000008333 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiPlasmoDB:PVX_084705.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RZ7X-ray2.35A1-846[»]
5DYLX-ray2.40A1-846[»]
5DZCX-ray2.30A1-846[»]
5F0AX-ray2.60A1-846[»]
5FETX-ray3.07A1-846[»]
ProteinModelPortaliA5K0N4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 166116Cyclic nucleotide-bindingInterPro annotationAdd
BLAST
Domaini169 – 268100Cyclic nucleotide-bindingInterPro annotationAdd
BLAST
Domaini288 – 391104Cyclic nucleotide-bindingInterPro annotationAdd
BLAST
Domaini411 – 510100Cyclic nucleotide-bindingInterPro annotationAdd
BLAST
Domaini534 – 791258Protein kinaseInterPro annotationAdd
BLAST
Domaini792 – 84655AGC-kinase C-terminalInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000281211.
InParanoidiA5K0N4.
KOiK07376.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR000961. AGC-kinase_C.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 4 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 3 hits.
PS00889. CNMP_BINDING_2. 3 hits.
PS50042. CNMP_BINDING_3. 4 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5K0N4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRCNERNKKK AIFSNDDFSG EDTLMEDHLQ LREKLSEDIE MIKASLKNNL
60 70 80 90 100
VCSTLNDNEI LTLSNYMQFF VFKGGDLVIK QGEKGSYFFI INSGKFDVYV
110 120 130 140 150
NDKKVKSMGK GSSFGEAALI HNTQRSATIM AETDGTLWGV QRSTFRATLK
160 170 180 190 200
QLSNRNFNEN RSFIDSVSVF DMLTEAQKNM ITNACVIQMF KPGETIVKQG
210 220 230 240 250
DYGDVLFILK EGKATVFIND KEIRVLNKGS YFGERALLYD EPRSATIIAK
260 270 280 290 300
EPTACASICR KLLNIVLGNL QVVLFRNIMT EALQQSEIFR QFSAEQLNDL
310 320 330 340 350
ADTAIVRDYP ANYHILHKDK VKSVKYLIVL EGKVELFLDD ESIGILTRGK
360 370 380 390 400
SFGDQYVLNQ KQKFRHTVKS LDVCKIALIT ESCLADCLGD NNIDASIDHN
410 420 430 440 450
NKKSIIKKMY IFRYLSEQQC NLLIEAFRTT RYEEGDYIIQ EGEVGSRFYI
460 470 480 490 500
IKNGEVEVTK NGKRLRTLGK NDYFGERALL YDEPRTASII SKATSVECWF
510 520 530 540 550
VDKSVFLQII QGPMLTHLEE RIKMQDTKVE MHELETERII GRGTFGTVKL
560 570 580 590 600
VHHKPTQIRY ALKCVSKRSI ISLNQQNNIK LEREITAEND HPFIIRLVRT
610 620 630 640 650
FKDSNCFYFL TELVTGGELY DAIRKLGLLS KPQAQFYLGS IILAIEYLHE
660 670 680 690 700
RNIVYRDLKP ENILLDKQGY VKLIDFGCAK KIQGRAYTLV GTPHYMAPEV
710 720 730 740 750
ILGKGYGCTV DIWALGVCLY EFICGPLPFG NDQEDQLEIF RDILTGQLTF
760 770 780 790 800
PDYVSDQDSI NLMKRLLCRL PQGRIGCSIN GFKDIKEHAF FGNFNWDKLA
810 820 830 840
GRLLEPPLVS KGETYAEDID IKQIEEEDAL NEGEPLDGDD SWDVDF
Length:846
Mass (Da):96,548
Last modified:July 10, 2007 - v1
Checksum:iF4816715FBBB8211
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKM01000002 Genomic DNA. Translation: EDL46881.1.
RefSeqiXP_001616608.1. XM_001616558.1.

Genome annotation databases

GeneIDi5475916.
KEGGipvx:PVX_084705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAKM01000002 Genomic DNA. Translation: EDL46881.1.
RefSeqiXP_001616608.1. XM_001616558.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4RZ7X-ray2.35A1-846[»]
5DYLX-ray2.40A1-846[»]
5DZCX-ray2.30A1-846[»]
5F0AX-ray2.60A1-846[»]
5FETX-ray3.07A1-846[»]
ProteinModelPortaliA5K0N4.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi5475916.
KEGGipvx:PVX_084705.

Organism-specific databases

EuPathDBiPlasmoDB:PVX_084705.

Phylogenomic databases

HOGENOMiHOG000281211.
InParanoidiA5K0N4.
KOiK07376.

Family and domain databases

Gene3Di2.60.120.10. 4 hits.
InterProiIPR000961. AGC-kinase_C.
IPR018490. cNMP-bd-like.
IPR018488. cNMP-bd_CS.
IPR000595. cNMP-bd_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR014710. RmlC-like_jellyroll.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 4 hits.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 4 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00888. CNMP_BINDING_1. 3 hits.
PS00889. CNMP_BINDING_2. 3 hits.
PS50042. CNMP_BINDING_3. 4 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Salvador IImported.
  2. "Crystal Structure of PVX_084705 with bound PCI32765."
    Jiang D.Q., Tempel W., Loppnau P., Graslund S., He H., Seitova A., Arrowsmith C.H., Edwards A.M., Bountra C., Hui R., Hutchinson A., El Bakkouri M., Amani M.
    Submitted (DEC-2014) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS).
  3. "CRYSTAL STRUCTURE OF PVX_084705 IN COMPLEX WITH AMP-PNP."
    STRUCTURAL GENOMICS CONSORTIUM (SGC)
    Walker J.R., El Bakkouri M., Loppnau P., Graslund S., He H., Seitova A., Hutchinson A., Bountra C., Edwards A.M., Arrowsmith C.H., Hui R., Amani M.
    Submitted (SEP-2015) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS).
  4. Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS).
  5. Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS).
  6. "Crystal Structure of PVX_084705 in presence of Compound 2."
    Wernimont A.K., Tempel W., Walker J.R., He H., Seitova A., Hills T., Neculai A.M., Baker D.A., Flueck C., Kettleborough C.A., Arrowsmith C.H., Edwards A.M., Bountra C., Hui R., Hutchinson A., El Bakkouri M.
    Submitted (DEC-2015) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (3.07 ANGSTROMS).

Entry informationi

Entry nameiA5K0N4_PLAVS
AccessioniPrimary (citable) accession number: A5K0N4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 10, 2007
Last sequence update: July 10, 2007
Last modified: May 11, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.