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Protein

Protein dhs-3

Gene

dhs-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in lipid droplet formation. May modulate triglyceride levels.1 Publication

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei190Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-CEL-5365859. RA biosynthesis pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dhs-3Curated
Alternative name(s):
Alcohol dehydrogenase dhs-3PROSITE-ProRule annotation (EC:1.1.1.1PROSITE-ProRule annotation)
Gene namesi
Name:dhs-3Imported
ORF Names:T02E1.5Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiT02E1.5a; CE41004; WBGene00000967; dhs-3.
T02E1.5b; CE41005; WBGene00000967; dhs-3.
T02E1.5c; CE41006; WBGene00000967; dhs-3.

Subcellular locationi

Keywords - Cellular componenti

Lipid droplet

Pathology & Biotechi

Disruption phenotypei

Viable, but intestinal cells contain lipid droplets that are reduced in size and that contained a reduced amount of triglycerides as compared to wild-type.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004422211 – 309Protein dhs-3CuratedAdd BLAST309

Proteomic databases

EPDiA5JYX5.
PaxDbiA5JYX5.
PeptideAtlasiA5JYX5.

Expressioni

Tissue specificityi

Expressed in the intestine and vulva.1 Publication

Developmental stagei

Not expressed in embryos.1 Publication

Gene expression databases

BgeeiWBGene00000967.
ExpressionAtlasiA5JYX5. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi6239.T02E1.5b.

Structurei

3D structure databases

ProteinModelPortaliA5JYX5.
SMRiA5JYX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 50Required for lipid droplet localization1 PublicationAdd BLAST50

Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1201. Eukaryota.
COG1028. LUCA.
GeneTreeiENSGT00540000069900.
InParanoidiA5JYX5.
KOiK15734.
OMAiKANHGHL.
OrthoDBiEOG091G0825.
PhylomeDBiA5JYX5.

Family and domain databases

InterProiView protein in InterPro
IPR036291. NAD(P)-bd_dom_sf.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform bImported (identifier: A5JYX5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPYVFLLSPQ LEIASQWDGY YEKTFEVSDH VHKEIILKVS GQTVLITGSG
60 70 80 90 100
SGLGRLMAFE FGKLGARLVL WDINEQGNKE TLKELEAMGV EAKAYTVDLS
110 120 130 140 150
EYKEINRTAD LVKSEVGKVD ILVNNAGIVT GKKLLQCPDE LMVKTVSVNT
160 170 180 190 200
NALFFTTKNF LPGMLESNKG HIVTIASMAG KCGVAGLVDY CASKHGAVGF
210 220 230 240 250
NDSLASELYA LKKDVKTTVV CPIYINTGMF DGIATKWPTL LPILSPEYVV
260 270 280 290 300
DCIMEAVLTD RAFLAIPKFS YIFIALAGLL PTEVLNLYGD HFGITHSMDH

FKGRQSRQA
Length:309
Mass (Da):33,885
Last modified:June 26, 2007 - v1
Checksum:iD015E4EC1D2BC0B9
GO
Isoform aImported (identifier: A5JYX5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-40: MPYVFLLSPQ...VHKEIILKVS → MQDILESVVV...MGWLLRKDVR

Show »
Length:307
Mass (Da):33,542
Checksum:iB636DF528BBBE29C
GO
Isoform cImported (identifier: A5JYX5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-141: Missing.

Show »
Length:168
Mass (Da):18,269
Checksum:i5F07388C6B4D8EF3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0592121 – 141Missing in isoform c. CuratedAdd BLAST141
Alternative sequenceiVSP_0592131 – 40MPYVF…ILKVS → MQDILESVVVTLHAICLLII STIRNCFPMGWLLRKDVR in isoform a. CuratedAdd BLAST40

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284601 Genomic DNA. Translation: CAN86610.1.
BX284601 Genomic DNA. Translation: CAN86611.1.
BX284601 Genomic DNA. Translation: CAN86612.1.
RefSeqiNP_001122508.1. NM_001129036.1. [A5JYX5-2]
NP_001122509.1. NM_001129037.2. [A5JYX5-1]
NP_001122510.1. NM_001129038.2. [A5JYX5-3]
UniGeneiCel.115.

Genome annotation databases

EnsemblMetazoaiT02E1.5a; T02E1.5a; WBGene00000967. [A5JYX5-2]
T02E1.5b; T02E1.5b; WBGene00000967. [A5JYX5-1]
T02E1.5c; T02E1.5c; WBGene00000967. [A5JYX5-3]
GeneIDi172603.
KEGGicel:CELE_T02E1.5.
UCSCiT02E1.5b. c. elegans. [A5JYX5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDHS3_CAEEL
AccessioniPrimary (citable) accession number: A5JYX5
Secondary accession number(s): A5JYX4, A5JYX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2017
Last sequence update: June 26, 2007
Last modified: December 20, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families