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Protein

Claudin

Gene

CLDN1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ClaudinUniRule annotation
Gene namesi
Name:CLDN1Imported
ORF Names:hCG_17574Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000163347.5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei79 – 98HelicalUniRule annotationAdd BLAST20
Transmembranei119 – 141HelicalUniRule annotationAdd BLAST23
Transmembranei161 – 184HelicalUniRule annotationAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membraneUniRule annotationSAAS annotation, Membrane, Tight junctionUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26557

Expressioni

Gene expression databases

BgeeiENSG00000163347

Interactioni

GO - Molecular functioni

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IG63 Eukaryota
ENOG4111GMP LUCA
HOVERGENiHBG000643
KOiK06087
OMAiIYEGLWM
OrthoDBiEOG091G0MX2

Family and domain databases

InterProiView protein in InterPro
IPR006187 Claudin
IPR003548 Claudin1
IPR017974 Claudin_CS
IPR004031 PMP22/EMP/MP20/Claudin
PANTHERiPTHR12002 PTHR12002, 1 hit
PTHR12002:SF92 PTHR12002:SF92, 1 hit
PfamiView protein in Pfam
PF00822 PMP22_Claudin, 1 hit
PRINTSiPR01377 CLAUDIN1
PROSITEiView protein in PROSITE
PS01346 CLAUDIN, 1 hit

Sequencei

Sequence statusi: Complete.

A5JSJ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANAGLQLLG FILAFLGWIG AIVSTALPQW RIYSYAGDNI VTAQAMYEGL
60 70 80 90 100
WMSCVSQSTG QIQCKVFDSL LNLSSTLQAT RALMVVGILL GVIAIFVATV
110 120 130 140 150
GMKCMKCLED DEVQKMRMAV IGGAIFLLAG LAILVATAWY GNRIVQEFYD
160 170 180 190 200
PMTPVNARYE FGQALFTGWA AASLCLLGGA LLCCSCPRKT TSYPTPRPYP
210
KPAPSSGKDY V
Length:211
Mass (Da):22,744
Last modified:June 26, 2007 - v1
Checksum:i07269000E6C214F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF564137 mRNA Translation: ABQ42705.1
AK312866 mRNA Translation: BAG35718.1
CH471052 Genomic DNA Translation: EAW78107.1
CH471052 Genomic DNA Translation: EAW78108.1
RefSeqiNP_066924.1, NM_021101.4
UniGeneiHs.439060

Genome annotation databases

GeneIDi9076
KEGGihsa:9076

Similar proteinsi

Entry informationi

Entry nameiA5JSJ9_HUMAN
AccessioniPrimary (citable) accession number: A5JSJ9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2007
Last sequence update: June 26, 2007
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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