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Protein

Anion exchange protein

Gene

SLC4A4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transportUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
Gene namesi
Name:SLC4A4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei469 – 492HelicalUniRule annotationAdd BLAST24
Transmembranei504 – 533HelicalUniRule annotationAdd BLAST30
Transmembranei553 – 571HelicalUniRule annotationAdd BLAST19
Transmembranei730 – 748HelicalUniRule annotationAdd BLAST19
Transmembranei777 – 797HelicalUniRule annotationAdd BLAST21
Transmembranei818 – 842HelicalUniRule annotationAdd BLAST25
Transmembranei878 – 897HelicalUniRule annotationAdd BLAST20
Transmembranei904 – 923HelicalUniRule annotationAdd BLAST20
Transmembranei955 – 986HelicalUniRule annotationAdd BLAST32

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35898.

PTM / Processingi

Proteomic databases

PaxDbiA5JJ20.
PRIDEiA5JJ20.

Expressioni

Gene expression databases

BgeeiENSG00000080493.
ExpressionAtlasiA5JJ20. baseline and differential.
GenevisibleiA5JJ20. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000393557.

Structurei

3D structure databases

ProteinModelPortaliA5JJ20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini138 – 387Band_3_cytoInterPro annotationAdd BLAST250
Domaini436 – 955HCO3_cotranspInterPro annotationAdd BLAST520

Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
OMAiVCSFMAL.
OrthoDBiEOG091G01FT.
PhylomeDBiA5JJ20.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequencei

Sequence statusi: Complete.

A5JJ20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDEAVLDRG ASFLKHVCDE EEVEGHHTIY IGVHVPKSYR RRRRHKRKTG
60 70 80 90 100
HKEKKEKERI SENYSDKSDI ENADESSSSI LKPLISPAAE RIRFILGEED
110 120 130 140 150
DSPAPPQLFT ELDELLAVDG QEMEWKETAR WIKFEEKVEQ GGERWSKPHV
160 170 180 190 200
ATLSLHSLFE LRTCMEKGSI MLDREASSLP QLVEMIVDHQ IETGLLKPEL
210 220 230 240 250
KDKVTYTLLR KHRHQTKKSN LRSLADIGKT VSSASRMFTN PDNGSPAMTH
260 270 280 290 300
RNLTSSSLND ISDKPEKDQL KNKFMKKLPR DAEASNVLVG EVDFLDTPFI
310 320 330 340 350
AFVRLQQAVM LGALTEVPVP TRFLFILLGP KGKAKSYHEI GRAIATLMSD
360 370 380 390 400
EVFHDIAYKA KDRHDLIAGI DEFLDEVIVL PPGEWDPAIR IEPPKSLPSS
410 420 430 440 450
DKRKNMYSGG ENVQMNGDTP HDGGHGGGGH GDCEELQRTG RFCGGLIKDI
460 470 480 490 500
KRKAPFFASD FYDALNIQAL SAILFIYLAT VTNAITFGGL LGDATDNMQG
510 520 530 540 550
VLESFLGTAV SGAIFCLFAG QPLTILSSTG PVLVFERLLF NFSKDNNFDY
560 570 580 590 600
LEFRLWIGLW SAFLCLILVA TDASFLVQYF TRFTEEGFSS LISFIFIYDA
610 620 630 640 650
FKKMIKLADY YPINSNFKVG YNTLFSCTCV PPDPANISIS NDTTLAPEYL
660 670 680 690 700
PTMSSTDMYH NTTFDWAFLS KKECSKYGGN LVGNNCNFVP DITLMSFILF
710 720 730 740 750
LGTYTSSMAL KKFKTSPYFP TTARKLISDF AIILSILIFC VIDALVGVDT
760 770 780 790 800
PKLIVPSEFK PTSPNRGWFV PPFGENPWWV CLAAAIPALL VTILIFMDQQ
810 820 830 840 850
ITAVIVNRKE HKLKKGAGYH LDLFWVAILM VICSLMALPW YVAATVISIA
860 870 880 890 900
HIDSLKMETE TSAPGEQPKF LGVREQRVTG TLVFILTGLS VFMAPILKFI
910 920 930 940 950
PMPVLYGVFL YMGVASLNGV QFMDRLKLLL MPLKHQPDFI YLRHVPLRRV
960 970 980 990 1000
HLFTFLQVLC LALLWILKST VAAIIFPVMI LALVAVRKGM DYLFSQHDLS
1010 1020 1030 1040 1050
FLDDVIPEKD KKKKEDEKKK KKKKGSLDSD NDDEKDHQHS LNATHHADKI
1060 1070 1080 1090
PFLQSLGMPS PPRTPVKVVP QIRIELEPED NDYFWRSKGT ETTL
Length:1,094
Mass (Da):123,181
Last modified:June 26, 2007 - v1
Checksum:iB02FF2193A5F95C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF531618 mRNA. Translation: ABQ43327.1.
RefSeqiNP_001128214.1. NM_001134742.1.
UniGeneiHs.5462.

Genome annotation databases

GeneIDi8671.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF531618 mRNA. Translation: ABQ43327.1.
RefSeqiNP_001128214.1. NM_001134742.1.
UniGeneiHs.5462.

3D structure databases

ProteinModelPortaliA5JJ20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000393557.

Proteomic databases

PaxDbiA5JJ20.
PRIDEiA5JJ20.

Protocols and materials databases

DNASUi8671.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8671.

Organism-specific databases

CTDi8671.
PharmGKBiPA35898.

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
OMAiVCSFMAL.
OrthoDBiEOG091G01FT.
PhylomeDBiA5JJ20.

Miscellaneous databases

ChiTaRSiSLC4A4. human.
GenomeRNAii8671.

Gene expression databases

BgeeiENSG00000080493.
ExpressionAtlasiA5JJ20. baseline and differential.
GenevisibleiA5JJ20. HS.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 2 hits.
PfamiPF07565. Band_3_cyto. 1 hit.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiA5JJ20_HUMAN
AccessioniPrimary (citable) accession number: A5JJ20
Entry historyi
Integrated into UniProtKB/TrEMBL: June 26, 2007
Last sequence update: June 26, 2007
Last modified: November 2, 2016
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.