A5J967 (A5J967_BURMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Shikimate dehydrogenase 1 HAMAP MF_00222
EC=1.1.1.25 HAMAP MF_00222

Gene names

Name:	aroE EMBL EDK54083.1
Synonyms:	aroE1 HAMAP MF_00222
ORF Names:	BMAFMH_0746 EMBL EDK54083.1

Organism

Burkholderia mallei FMH EMBL EDK54083.1

Taxonomic identifier

334802 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Betaproteobacteria › Burkholderiales › Burkholderiaceae › Burkholderia › pseudomallei group

Protein attributes

Sequence length	292 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Shikimate + NADP+ = 3-dehydroshikimate + NADPH. HAMAP MF_00222 SAAS SAAS011342
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7. HAMAP MF_00222 SAAS SAAS011342
Sequence similarities	Belongs to the shikimate dehydrogenase family. HAMAP MF_00222

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis HAMAP MF_00222 SAAS SAAS011342
Ligand	NADP HAMAP MF_00222 SAAS SAAS011342
Molecular function	Oxidoreductase HAMAP MF_00222 RuleBase RU004037 SAAS SAAS011342 EMBL EDK54083.1
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	NADP binding Inferred from electronic annotation. Source: InterPro shikimate 3-dehydrogenase (NADP+) activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	137 – 141	5	NADP By similarity HAMAP MF_00222
Sites
	Active site	76	1	Proton acceptor By similarity HAMAP MF_00222

Sequences

	Sequence		Length	Mass (Da)
	A5J967 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 1FC4AA40A1940D77	FASTA	292	30,004
	10 20 30 40 50 60 MSTAVESAAR ARDRYAVIGN PIAHSKSPFI HSRFAEQTGE AIEYTHLLAP LDGFSATVRA 70 80 90 100 110 120 FIAQGGRGVN VTVPFKLEAY ALADALSPRA AAAGAVNTLR FDADGVFGDN TDGVGLVRDI 130 140 150 160 170 180 EVNLGVSLTG ARILLLGAGG AARGVVLPML ERGPASLTIV NRTASKAEEL VGQFTQAAHD 190 200 210 220 230 240 AGCVLAGGGP ERIAREPYDV IVNATAGSLD AALPECDAAA FGPATLAYDM MYGARPTVFM 250 260 270 280 290 EHAAALGART ADGLGMLVEQ AAESFHVWRG VRPDSAPVLA ALRAALAASA AH

References

[1]	DeShazer D., Woods D.E., Nierman W.C. Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: FMH EMBL EDK54083.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DS264097 Genomic DNA. Translation: EDK54083.1.
3D structure databases
ProteinModelPortal	A5J967.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
PATRIC	26917840. VBIBurMal45758_4002.
Phylogenomic databases
OMA	VVFGNPI.
Family and domain databases
HAMAP	MF_00222. Shikimate_DH_AroE. [Tree]
InterPro	IPR016040. NAD(P)-bd_dom. IPR011342. Shikimate_DH. IPR013708. Shikimate_DH-bd_N. IPR022893. Shikimate_quinate_DH. IPR006151. Shikm_DH/Glu-tRNA_Rdtase. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01488. Shikimate_DH. 1 hit. PF08501. Shikimate_dh_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00507. AroE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

A5J967_BURMA

Accession

Primary (citable) accession number: A5J967

Entry history

Integrated into UniProtKB/TrEMBL:	June 26, 2007
Last sequence update:	June 26, 2007
Last modified:	December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)