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Protein

Thymidine kinase

Gene

tdk

Organism
Mycoplasma agalactiae (strain PG2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptorUniRule annotation
Metal bindingi145 – 1451ZincUniRule annotation
Metal bindingi148 – 1481ZincUniRule annotation
Metal bindingi176 – 1761ZincUniRule annotation
Metal bindingi179 – 1791ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 228ATPUniRule annotation
Nucleotide bindingi88 – 914ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciMAGA347257:GC07-740-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
Ordered Locus Names:MAG7010Imported
OrganismiMycoplasma agalactiae (strain PG2)Imported
Taxonomic identifieri347257 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
ProteomesiUP000007065 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi347257.MAG_7010.

Structurei

3D structure databases

ProteinModelPortaliA5IZE2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

A5IZE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLKNGLGQL EVITGPMFSG KTEELLKRIN ILKIAGINSL VIKPKFDTRF
60 70 80 90 100
SENEIVSRTG AKHKAINVSS SKEILDHWST KYMCVAIDEV NFMDEDILSV
110 120 130 140 150
IEELIYKGVK VICSGLDMDF KRRPFDVMAK VLASADSILK LKAVCLECKS
160 170 180 190
DAGFSFRKVK SDELNLLGDS EYEARCRICH IKGEKEKAKM
Length:190
Mass (Da):21,403
Last modified:June 25, 2007 - v1
Checksum:i54A7DE9D9C13D69F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU179680 Genomic DNA. Translation: CAL59401.1.
RefSeqiWP_011949854.1. NC_009497.1.
YP_001256839.1. NC_009497.1.

Genome annotation databases

EnsemblBacteriaiCAL59401; CAL59401; MAG7010.
KEGGimaa:MAG_7010.
PATRICi32272948. VBIMycAga119067_0748.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU179680 Genomic DNA. Translation: CAL59401.1.
RefSeqiWP_011949854.1. NC_009497.1.
YP_001256839.1. NC_009497.1.

3D structure databases

ProteinModelPortaliA5IZE2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi347257.MAG_7010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL59401; CAL59401; MAG7010.
KEGGimaa:MAG_7010.
PATRICi32272948. VBIMycAga119067_0748.

Phylogenomic databases

HOGENOMiHOG000076390.
KOiK00857.
OMAiVITGPMY.
OrthoDBiEOG69D3J2.

Enzyme and pathway databases

BioCyciMAGA347257:GC07-740-MONOMER.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PG2Imported.

Entry informationi

Entry nameiA5IZE2_MYCAP
AccessioniPrimary (citable) accession number: A5IZE2
Entry historyi
Integrated into UniProtKB/TrEMBL: June 25, 2007
Last sequence update: June 25, 2007
Last modified: March 31, 2015
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.