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Protein

Pseudouridine-5'-phosphate glycosidase

Gene

psuG

Organism
Mycoplasma agalactiae (strain PG2)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.UniRule annotation

Catalytic activityi

Uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O.UniRule annotation

Cofactori

Mn2+UniRule annotationNote: Binds 1 Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei23Proton donorUniRule annotation1
Binding sitei84SubstrateUniRule annotation1
Binding sitei104Substrate; via amide nitrogenUniRule annotation1
Metal bindingi136ManganeseUniRule annotation1
Active sitei157NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase, Lyase

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciMAGA347257:GC07-27-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pseudouridine-5'-phosphate glycosidaseUniRule annotation (EC:4.2.1.70UniRule annotation)
Short name:
PsiMP glycosidaseUniRule annotation
Gene namesi
Name:psuGUniRule annotation
Ordered Locus Names:MAG0250
OrganismiMycoplasma agalactiae (strain PG2)
Taxonomic identifieri347257 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000007065 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003905301 – 301Pseudouridine-5'-phosphate glycosidaseAdd BLAST301

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 140Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the pseudouridine-5'-phosphate glycosidase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000064311.
KOiK16329.
OMAiIIAHGMP.
OrthoDBiPOG091H08AG.

Family and domain databases

HAMAPiMF_01876. PsiMP_glycosidase. 1 hit.
InterProiIPR007342. PsuG.
[Graphical view]
PANTHERiPTHR10584:SF1. PTHR10584:SF1. 1 hit.
PfamiPF04227. Indigoidine_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5IXG3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIVFSKEVE SALKHKRPVV ALESTIITHG MPYPKNVEMA LNVENIIRKQ
60 70 80 90 100
GAVPATIAII NGIIHVGLEN DEINELAKLK DVIKTSKRDF GYVLANKKNG
110 120 130 140 150
GTTVSGTVLV AQKVGIPVFA TGGIGGVHRG AEITFDISRD LDELSTNNVL
160 170 180 190 200
VVCAGAKLIL DLGLTLEYLE TKGVEVLGYN SDKLPAFYSS SSEFNVTYNV
210 220 230 240 250
HSASEVAAIM KAKWKFTNGG IILANPIPEQ YGLEYEYILD NINKAIEQAK
260 270 280 290 300
VEGISGKKTT PYLLSKVLEL TEGKSLEANI QLVYNNAKVA AQVAVEYAKQ

K
Length:301
Mass (Da):32,622
Last modified:June 26, 2007 - v1
Checksum:i66DF58EBD252F841
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU179680 Genomic DNA. Translation: CAL58722.1.
RefSeqiWP_011949208.1. NC_009497.1.

Genome annotation databases

EnsemblBacteriaiCAL58722; CAL58722; MAG0250.
KEGGimaa:MAG0250.
PATRICi32271444. VBIMycAga119067_0029.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU179680 Genomic DNA. Translation: CAL58722.1.
RefSeqiWP_011949208.1. NC_009497.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAL58722; CAL58722; MAG0250.
KEGGimaa:MAG0250.
PATRICi32271444. VBIMycAga119067_0029.

Phylogenomic databases

HOGENOMiHOG000064311.
KOiK16329.
OMAiIIAHGMP.
OrthoDBiPOG091H08AG.

Enzyme and pathway databases

BioCyciMAGA347257:GC07-27-MONOMER.

Family and domain databases

HAMAPiMF_01876. PsiMP_glycosidase. 1 hit.
InterProiIPR007342. PsuG.
[Graphical view]
PANTHERiPTHR10584:SF1. PTHR10584:SF1. 1 hit.
PfamiPF04227. Indigoidine_A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSUG_MYCAP
AccessioniPrimary (citable) accession number: A5IXG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: June 26, 2007
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.