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A5IW58

- ARCR_STAA9

UniProt

A5IW58 - ARCR_STAA9

Protein

HTH-type transcriptional regulator ArcR

Gene

arcR

Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Positively regulates the expression of the arcABDCR operon under anaerobic conditions, thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 12990cNMPAdd
    BLAST
    DNA bindingi188 – 20720H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. cAMP binding Source: UniProtKB-KW
    2. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    cAMP, cAMP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciSAUR359786:GJEM-2737-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional regulator ArcR
    Gene namesi
    Name:arcR
    Ordered Locus Names:SaurJH9_2655
    OrganismiStaphylococcus aureus (strain JH9)
    Taxonomic identifieri359786 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001984: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 234234HTH-type transcriptional regulator ArcRPRO_0000349407Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi359786.SaurJH9_2655.

    Structurei

    3D structure databases

    ProteinModelPortaliA5IW58.
    SMRiA5IW58. Positions 31-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini155 – 22874HTH crp-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH crp-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0664.
    HOGENOMiHOG000022896.
    OMAiERVNQNG.
    OrthoDBiEOG6QRWC5.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProiIPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 1 hit.
    PROSITEiPS51063. HTH_CRP_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5IW58-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTENFILGRN NKLEHELKAL ADYINIPYSI LQPYQSECFV RHYTKGQVIY    50
    FSPQESSNIY FLIEGNIIRE HYNQNGDVYR YFNKEQVLFP ISNLFHPKEV 100
    NELCTALTDC TVLGLPRELM AFLCKANDDI FLTLFALIND NEQQHMNYNM 150
    ALTSKFAKDR IIKLLCHLCQ TVGYDQDEFY EIKQFLTIQL MSDMAGISRE 200
    TAGHIIHELK DEKLVVKDHK NWLVSKHLFN DVCV 234
    Length:234
    Mass (Da):27,428
    Last modified:June 26, 2007 - v1
    Checksum:iA63E59D8A1ED4E1E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000703 Genomic DNA. Translation: ABQ50431.1.
    RefSeqiYP_001248007.1. NC_009487.1.

    Genome annotation databases

    EnsemblBacteriaiABQ50431; ABQ50431; SaurJH9_2655.
    GeneIDi5167722.
    KEGGisaj:SaurJH9_2655.
    PATRICi19543325. VBIStaAur42398_2801.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000703 Genomic DNA. Translation: ABQ50431.1 .
    RefSeqi YP_001248007.1. NC_009487.1.

    3D structure databases

    ProteinModelPortali A5IW58.
    SMRi A5IW58. Positions 31-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359786.SaurJH9_2655.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ50431 ; ABQ50431 ; SaurJH9_2655 .
    GeneIDi 5167722.
    KEGGi saj:SaurJH9_2655.
    PATRICi 19543325. VBIStaAur42398_2801.

    Phylogenomic databases

    eggNOGi COG0664.
    HOGENOMi HOG000022896.
    OMAi ERVNQNG.
    OrthoDBi EOG6QRWC5.

    Enzyme and pathway databases

    BioCyci SAUR359786:GJEM-2737-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    2.60.120.10. 1 hit.
    InterProi IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR012318. HTH_CRP_2.
    IPR014710. RmlC-like_jellyroll.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 1 hit.
    PROSITEi PS51063. HTH_CRP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., Tomasz A., Richardson P.
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JH9.

    Entry informationi

    Entry nameiARCR_STAA9
    AccessioniPrimary (citable) accession number: A5IW58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3