Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Copper-exporting P-type ATPase A

Gene

copA

Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in copper export.By similarity

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi16Copper 1PROSITE-ProRule annotation1
Metal bindingi19Copper 1PROSITE-ProRule annotation1
Metal bindingi83Copper 2PROSITE-ProRule annotation1
Metal bindingi86Copper 2PROSITE-ProRule annotation1
Active sitei4954-aspartylphosphate intermediateBy similarity1
Metal bindingi690MagnesiumPROSITE-ProRule annotation1
Metal bindingi694MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-exporting P-type ATPase A (EC:3.6.3.54)
Alternative name(s):
Cu(+)-exporting ATPase
Gene namesi
Name:copA
Ordered Locus Names:SaurJH9_2579
OrganismiStaphylococcus aureus (strain JH9)
Taxonomic identifieri359786 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei161 – 181HelicalSequence analysisAdd BLAST21
Transmembranei192 – 212HelicalSequence analysisAdd BLAST21
Transmembranei224 – 244HelicalSequence analysisAdd BLAST21
Transmembranei256 – 276HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei748 – 767HelicalSequence analysisAdd BLAST20
Transmembranei771 – 790HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003505861 – 802Copper-exporting P-type ATPase AAdd BLAST802

Keywords - PTMi

Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliA5IVY3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 71HMA 1PROSITE-ProRule annotationAdd BLAST66
Domaini73 – 139HMA 2PROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Contains 2 HMA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000250397.
KOiK17686.
OMAiQDGSTDH.

Family and domain databases

CDDicd00371. HMA. 2 hits.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5IVY3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANTKKTTLD ITGMTCAACS NRIEKKLNKL DDVNAQVNLT TEKATVEYNP
60 70 80 90 100
DQHDVQEFIN TIQHLGYGVT VETVELDITG MTCAACSSRI EKVLNKMNGV
110 120 130 140 150
QNATVNLTTE QAKVDYYPEE TDADKLVTRI QKLGYDASIK DNNKDQTSRK
160 170 180 190 200
AEALQHKLIK LIISAVLSLP LLMLMFVHLF NMHIPALFTN PWFQFILATP
210 220 230 240 250
VQFIIGWQFY VGAYKNLRNG GANMDVLVAV GTSAAYFYSI YEMVRWLNGS
260 270 280 290 300
TTQPHLYFET SAVLLTLILF GKYLEARAKS QTTNALGELL SLQAKEARIL
310 320 330 340 350
KDGNEVMIPL NEVHVGDTLI VKPGEKIPVD GKIIKGMTAI DESMLTGESI
360 370 380 390 400
PVEKNVDDTV IGSTMNKNGT ITMTATKVGG DTALANIIKV VEEAQSSKAP
410 420 430 440 450
IQRLADIISG YFVPIVVGIA LLIFIVWITL VTPGTFEPAL VASISVLVIA
460 470 480 490 500
CPCALGLATP TSIMVGTGRA AENGILFKGG EFVERTHQID TIVLDKTGTI
510 520 530 540 550
TNGRPVVTDY HGDNQTLQLL ATAEKDSEHP LAEAIVNYAK EKQLTLTETT
560 570 580 590 600
TFKAVPGHGI EATIDHHHIL VGNRKLMADN DISLPKHISD DLTHYERDGK
610 620 630 640 650
TAMLIAVNYS LTGIIAVADT VKDHAKDAIK QLHDMGIEVA MLTGDNKNTA
660 670 680 690 700
QAIAKQVGID TVIADILPEE KAAQIAKLQQ QGKKVAMVGD GVNDAPALVK
710 720 730 740 750
ADIGIAIGTG TEVAIEAADI TILGGDLMLI PKAIYASKAT IRNIRQNLFW
760 770 780 790 800
AFGYNIAGIP IAALGLLAPW VAGAAMALSS VSVVTNALRL KKMRLEPRRK

DA
Length:802
Mass (Da):86,773
Last modified:June 26, 2007 - v1
Checksum:i2BCC0B7D7E173DDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA. Translation: ABQ50356.1.
RefSeqiWP_000024139.1. NC_009487.1.

Genome annotation databases

EnsemblBacteriaiABQ50356; ABQ50356; SaurJH9_2579.
KEGGisaj:SaurJH9_2579.
PATRICi19543169. VBIStaAur42398_2723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA. Translation: ABQ50356.1.
RefSeqiWP_000024139.1. NC_009487.1.

3D structure databases

ProteinModelPortaliA5IVY3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ50356; ABQ50356; SaurJH9_2579.
KEGGisaj:SaurJH9_2579.
PATRICi19543169. VBIStaAur42398_2723.

Phylogenomic databases

HOGENOMiHOG000250397.
KOiK17686.
OMAiQDGSTDH.

Family and domain databases

CDDicd00371. HMA. 2 hits.
Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006122. HMA_Cu_ion-bd.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 2 hits.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
TIGR00003. TIGR00003. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 2 hits.
PS50846. HMA_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOPA_STAA9
AccessioniPrimary (citable) accession number: A5IVY3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: June 26, 2007
Last modified: November 30, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.