A5IVY0 (ROCA_STAA9) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 41.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 1-pyrroline-5-carboxylate dehydrogenase Short name=P5C dehydrogenase EC=1.5.1.12 | ||||
| Gene names |
| ||||
| Organism | Staphylococcus aureus (strain JH9) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 359786 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Staphylococcus |
Protein attributes
| Sequence length | 514 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | (S)-1-pyrroline-5-carboxylate + NAD(P)+ + 2 H2O = L-glutamate + NAD(P)H. HAMAP MF_00733 |
| Pathway | Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2. HAMAP MF_00733 |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. RocA subfamily. |
Ontologies
| Keywords | |
|---|---|
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proline biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | 1-pyrroline-5-carboxylate dehydrogenase activity Inferred from electronic annotation. Source: EC oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptorInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 514 | 514 | 1-pyrroline-5-carboxylate dehydrogenase HAMAP MF_00733 | PRO_1000083341 | |||||
Sites | |||||||||
| Active site | 286 | 1 | By similarity | ||||||
| Active site | 320 | 1 | By similarity | ||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. Richardson P.Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JH9. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000703 Genomic DNA. Translation: ABQ50353.1. |
| RefSeq | YP_001247929.1. NC_009487.1. |
3D structure databases | |
| ProteinModelPortal | A5IVY0. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | A5IVY0. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblBacteria | EBSTAT00000017485; EBSTAP00000016904; EBSTAG00000017484. |
| GeneID | 5167191. |
| GenomeReviews | Gene locus SaurJH9_2576 in contig CP000703_GR. |
| KEGG | saj:SaurJH9_2576. |
| PATRIC | 19543163. VBIStaAur42398_2720. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| eggNOG | COG1012. |
| GeneTree | EBGT00050000023967. |
| HOGENOM | HBG752218. |
| OMA | SINPANT. |
| ProtClustDB | PRK03137. |
Enzyme and pathway databases | |
| BioCyc | SAUR359786:SAURJH9_2576-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00733. RocA. [Tree] |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR005932. Delta1-pyrroline-5-COlate_DH-2. [Graphical view] |
| Gene3D | G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| KO | K00294. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| SUPFAM | SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit. |
| TIGRFAMs | TIGR01237. D1pyr5carbox2. 1 hit. |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ROCA_STAA9 | ||||||||
| Accession | Primary (citable) accession number: A5IVY0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with