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A5IVH2

- NREC_STAA9

UniProt

A5IVH2 - NREC_STAA9

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Protein
Oxygen regulatory protein NreC
Gene
nreC, SaurJH9_2415
Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi172 – 19120H-T-H motif By similarity
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. phosphorelay response regulator activity Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation, Two-component regulatory system

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSAUR359786:GJEM-2498-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen regulatory protein NreC
Alternative name(s):
Nitrogen regulation protein C
Gene namesi
Name:nreC
Ordered Locus Names:SaurJH9_2415
OrganismiStaphylococcus aureus (strain JH9)
Taxonomic identifieri359786 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001984: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217Oxygen regulatory protein NreC
PRO_0000349345Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei53 – 5314-aspartylphosphate By similarity

Post-translational modificationi

Phosphorylated by NreB By similarity.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiA5IVH2.

Interactioni

Protein-protein interaction databases

STRINGi359786.SaurJH9_2415.

Structurei

3D structure databases

ProteinModelPortaliA5IVH2.
SMRiA5IVH2. Positions 1-216.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 119118Response regulatory
Add
BLAST
Domaini148 – 21366HTH luxR-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2197.
HOGENOMiHOG000034813.
KOiK07696.
OMAiYQEDMEV.
OrthoDBiEOG69GZGV.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSiPR00038. HTHLUXR.
SMARTiSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5IVH2-1 [UniParc]FASTAAdd to Basket

« Hide

MKIVIADDHA VVRTGFSMIL NYQNDMEVVA TAADGVEAYQ KVMEYKPDVL    50
LMDLSMPPGE SGLIATSKIA DSFPETKILI LTMFDDEEYL FHVLRNGAKG 100
YILKNAPDEQ LLLAIRTVYK GETYVDMKLT TSLVNEFVSN SNQDTANTTD 150
PFKILSKREL EILPLIAKGY GNKEIAEKLF VSVKTVEAHK THIMTKLGLK 200
SKPELVEYAL KKKLLEF 217
Length:217
Mass (Da):24,368
Last modified:June 26, 2007 - v1
Checksum:iDDF2969C5B277320
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000703 Genomic DNA. Translation: ABQ50195.1.
RefSeqiYP_001247771.1. NC_009487.1.

Genome annotation databases

EnsemblBacteriaiABQ50195; ABQ50195; SaurJH9_2415.
GeneIDi5168495.
KEGGisaj:SaurJH9_2415.
PATRICi19542831. VBIStaAur42398_2554.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000703 Genomic DNA. Translation: ABQ50195.1 .
RefSeqi YP_001247771.1. NC_009487.1.

3D structure databases

ProteinModelPortali A5IVH2.
SMRi A5IVH2. Positions 1-216.
ModBasei Search...

Protein-protein interaction databases

STRINGi 359786.SaurJH9_2415.

Proteomic databases

PRIDEi A5IVH2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ50195 ; ABQ50195 ; SaurJH9_2415 .
GeneIDi 5168495.
KEGGi saj:SaurJH9_2415.
PATRICi 19542831. VBIStaAur42398_2554.

Phylogenomic databases

eggNOGi COG2197.
HOGENOMi HOG000034813.
KOi K07696.
OMAi YQEDMEV.
OrthoDBi EOG69GZGV.

Enzyme and pathway databases

BioCyci SAUR359786:GJEM-2498-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view ]
PRINTSi PR00038. HTHLUXR.
SMARTi SM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEi PS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., Tomasz A., Richardson P.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JH9.

Entry informationi

Entry nameiNREC_STAA9
AccessioniPrimary (citable) accession number: A5IVH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 26, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi