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A5IVH2

- NREC_STAA9

UniProt

A5IVH2 - NREC_STAA9

Protein

Oxygen regulatory protein NreC

Gene

nreC

Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi172 – 19120H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation, Two-component regulatory system

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciSAUR359786:GJEM-2498-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Oxygen regulatory protein NreC
    Alternative name(s):
    Nitrogen regulation protein C
    Gene namesi
    Name:nreC
    Ordered Locus Names:SaurJH9_2415
    OrganismiStaphylococcus aureus (strain JH9)
    Taxonomic identifieri359786 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001984: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 217217Oxygen regulatory protein NreCPRO_0000349345Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 5314-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated by NreB.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiA5IVH2.

    Interactioni

    Protein-protein interaction databases

    STRINGi359786.SaurJH9_2415.

    Structurei

    3D structure databases

    ProteinModelPortaliA5IVH2.
    SMRiA5IVH2. Positions 1-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 119118Response regulatoryPROSITE-ProRule annotationAdd
    BLAST
    Domaini148 – 21366HTH luxR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH luxR-type DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2197.
    HOGENOMiHOG000034813.
    KOiK07696.
    OMAiYQEDMEV.
    OrthoDBiEOG69GZGV.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR016032. Sig_transdc_resp-reg_C-effctor.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR000792. Tscrpt_reg_LuxR_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00196. GerE. 1 hit.
    PF00072. Response_reg. 1 hit.
    [Graphical view]
    PRINTSiPR00038. HTHLUXR.
    SMARTiSM00421. HTH_LUXR. 1 hit.
    SM00448. REC. 1 hit.
    [Graphical view]
    SUPFAMiSSF46894. SSF46894. 1 hit.
    SSF52172. SSF52172. 1 hit.
    PROSITEiPS00622. HTH_LUXR_1. 1 hit.
    PS50043. HTH_LUXR_2. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5IVH2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKIVIADDHA VVRTGFSMIL NYQNDMEVVA TAADGVEAYQ KVMEYKPDVL    50
    LMDLSMPPGE SGLIATSKIA DSFPETKILI LTMFDDEEYL FHVLRNGAKG 100
    YILKNAPDEQ LLLAIRTVYK GETYVDMKLT TSLVNEFVSN SNQDTANTTD 150
    PFKILSKREL EILPLIAKGY GNKEIAEKLF VSVKTVEAHK THIMTKLGLK 200
    SKPELVEYAL KKKLLEF 217
    Length:217
    Mass (Da):24,368
    Last modified:June 26, 2007 - v1
    Checksum:iDDF2969C5B277320
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000703 Genomic DNA. Translation: ABQ50195.1.
    RefSeqiYP_001247771.1. NC_009487.1.

    Genome annotation databases

    EnsemblBacteriaiABQ50195; ABQ50195; SaurJH9_2415.
    GeneIDi5168495.
    KEGGisaj:SaurJH9_2415.
    PATRICi19542831. VBIStaAur42398_2554.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000703 Genomic DNA. Translation: ABQ50195.1 .
    RefSeqi YP_001247771.1. NC_009487.1.

    3D structure databases

    ProteinModelPortali A5IVH2.
    SMRi A5IVH2. Positions 1-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359786.SaurJH9_2415.

    Proteomic databases

    PRIDEi A5IVH2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ50195 ; ABQ50195 ; SaurJH9_2415 .
    GeneIDi 5168495.
    KEGGi saj:SaurJH9_2415.
    PATRICi 19542831. VBIStaAur42398_2554.

    Phylogenomic databases

    eggNOGi COG2197.
    HOGENOMi HOG000034813.
    KOi K07696.
    OMAi YQEDMEV.
    OrthoDBi EOG69GZGV.

    Enzyme and pathway databases

    BioCyci SAUR359786:GJEM-2498-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR016032. Sig_transdc_resp-reg_C-effctor.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR000792. Tscrpt_reg_LuxR_C.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00196. GerE. 1 hit.
    PF00072. Response_reg. 1 hit.
    [Graphical view ]
    PRINTSi PR00038. HTHLUXR.
    SMARTi SM00421. HTH_LUXR. 1 hit.
    SM00448. REC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46894. SSF46894. 1 hit.
    SSF52172. SSF52172. 1 hit.
    PROSITEi PS00622. HTH_LUXR_1. 1 hit.
    PS50043. HTH_LUXR_2. 1 hit.
    PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., Tomasz A., Richardson P.
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JH9.

    Entry informationi

    Entry nameiNREC_STAA9
    AccessioniPrimary (citable) accession number: A5IVH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3