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A5IVH2 (NREC_STAA9) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen regulatory protein NreC
Alternative name(s):
Nitrogen regulation protein C
Gene names
Name:nreC
Ordered Locus Names:SaurJH9_2415
OrganismStaphylococcus aureus (strain JH9) [Complete proteome] [HAMAP]
Taxonomic identifier359786 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length217 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression By similarity.

Subcellular location

Cytoplasm Potential.

Post-translational modification

Phosphorylated by NreB By similarity.

Sequence similarities

Contains 1 HTH luxR-type DNA-binding domain.

Contains 1 response regulatory domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
Two-component regulatory system
   Cellular componentCytoplasm
   LigandDNA-binding
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphorelay response regulator activity

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 217217Oxygen regulatory protein NreC
PRO_0000349345

Regions

Domain2 – 119118Response regulatory
Domain148 – 21366HTH luxR-type
DNA binding172 – 19120H-T-H motif By similarity

Amino acid modifications

Modified residue5314-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
A5IVH2 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: DDF2969C5B277320

FASTA21724,368
        10         20         30         40         50         60 
MKIVIADDHA VVRTGFSMIL NYQNDMEVVA TAADGVEAYQ KVMEYKPDVL LMDLSMPPGE 

        70         80         90        100        110        120 
SGLIATSKIA DSFPETKILI LTMFDDEEYL FHVLRNGAKG YILKNAPDEQ LLLAIRTVYK 

       130        140        150        160        170        180 
GETYVDMKLT TSLVNEFVSN SNQDTANTTD PFKILSKREL EILPLIAKGY GNKEIAEKLF 

       190        200        210 
VSVKTVEAHK THIMTKLGLK SKPELVEYAL KKKLLEF 

« Hide

References

[1]"Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Tomasz A., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JH9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000703 Genomic DNA. Translation: ABQ50195.1.
RefSeqYP_001247771.1. NC_009487.1.

3D structure databases

ProteinModelPortalA5IVH2.
SMRA5IVH2. Positions 1-216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359786.SaurJH9_2415.

Proteomic databases

PRIDEA5IVH2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ50195; ABQ50195; SaurJH9_2415.
GeneID5168495.
KEGGsaj:SaurJH9_2415.
PATRIC19542831. VBIStaAur42398_2554.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2197.
HOGENOMHOG000034813.
KOK07696.
OMASMILNFQ.
OrthoDBEOG69GZGV.
ProtClustDBCLSK885949.

Enzyme and pathway databases

BioCycSAUR359786:GJEM-2498-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR000792. Tscrpt_reg_LuxR_C.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00196. GerE. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PRINTSPR00038. HTHLUXR.
SMARTSM00421. HTH_LUXR. 1 hit.
SM00448. REC. 1 hit.
[Graphical view]
SUPFAMSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEPS00622. HTH_LUXR_1. 1 hit.
PS50043. HTH_LUXR_2. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameNREC_STAA9
AccessionPrimary (citable) accession number: A5IVH2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 26, 2007
Last modified: April 16, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families