A5IVE2 (HSSR_STAA9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heme response regulator HssR

Gene names

Name:	hssR
Ordered Locus Names:	SaurJH9_2385

Organism

Staphylococcus aureus (strain JH9) [Complete proteome] [HAMAP]

Taxonomic identifier

359786 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Staphylococcus aureus subsp. aureus

Protein attributes

Sequence length	224 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood By similarity.
Subcellular location	Cytoplasm Potential.
Post-translational modification	Phosphorylated by HssS By similarity.
Sequence similarities	Contains 1 response regulatory domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation Two-component regulatory system Virulence
Cellular component	Cytoplasm
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: GOC pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW phosphorelay response regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 224	224	Heme response regulator HssR		PRO_0000331322
Regions
	Domain	3 – 116	114	Response regulatory
Amino acid modifications
	Modified residue	52	1	4-aspartylphosphate By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5IVE2 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 251BF68572E9155A	FASTA	224	25,946
	10 20 30 40 50 60 MVQCLVVDDD PRILNYIASH LQTEHIDAYT QPSGEAALKL LEKQRVDIAV VDIMMDGMDG 70 80 90 100 110 120 FQLCNTLKND YDIPVIMLTA RDALSDKERA FISGTDDYVT KPFEVKELIF RIRAVLRRYN 130 140 150 160 170 180 INSNSEMTIG NLTLNQSYLE LQVSNKTMTL PNKEFQLLFM LAARPKQIFT REQIIEKIWG 190 200 210 220 YDYEGDERTV DVHIKRLRQR LKKLNATLTI ETVRGQGYKV ENHV

References

[1]

"Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Tomasz A., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JH9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000703 Genomic DNA. Translation: ABQ50165.1.
RefSeq	YP_001247741.1. NC_009487.1.
3D structure databases
ProteinModelPortal	A5IVE2.
SMR	A5IVE2. Positions 5-221.
ModBase	Search...
Protein-protein interaction databases
STRING	359786.SaurJH9_2385.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ50165; ABQ50165; SaurJH9_2385.
GeneID	5169102.
KEGG	saj:SaurJH9_2385.
PATRIC	19542773. VBIStaAur42398_2525.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0745.
HOGENOM	HOG000034819.
OMA	CLIVDDD.
ProtClustDB	CLSK885926.
Enzyme and pathway databases
BioCyc	SAUR359786:GJEM-2468-MONOMER.
Family and domain databases
Gene3D	1.10.10.10. 1 hit.
InterPro	IPR011006. CheY-like_superfamily. IPR001867. Sig_transdc_resp-reg_C. IPR001789. Sig_transdc_resp-reg_receiver. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00072. Response_reg. 1 hit. PF00486. Trans_reg_C. 1 hit. [Graphical view]
SMART	SM00448. REC. 1 hit. SM00862. Trans_reg_C. 1 hit. [Graphical view]
SUPFAM	SSF52172. CheY_like. 1 hit.
PROSITE	PS50110. RESPONSE_REGULATORY. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HSSR_STAA9

Accession

Primary (citable) accession number: A5IVE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	June 26, 2007
Last modified:	May 1, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program