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A5IVE2

- HSSR_STAA9

UniProt

A5IVE2 - HSSR_STAA9

Protein

Heme response regulator HssR

Gene

hssR

Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (26 Jun 2007)
      Previous versions | rss
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    Functioni

    Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood By similarity.By similarity

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. phosphorelay response regulator activity Source: InterPro

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. regulation of transcription, DNA-templated Source: UniProtKB-KW
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation, Two-component regulatory system, Virulence

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    BioCyciSAUR359786:GJEM-2468-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme response regulator HssR
    Gene namesi
    Name:hssR
    Ordered Locus Names:SaurJH9_2385
    OrganismiStaphylococcus aureus (strain JH9)
    Taxonomic identifieri359786 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
    ProteomesiUP000001984: Chromosome

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 224224Heme response regulator HssRPRO_0000331322Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei52 – 5214-aspartylphosphatePROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylated by HssS.By similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi359786.SaurJH9_2385.

    Structurei

    3D structure databases

    ProteinModelPortaliA5IVE2.
    SMRiA5IVE2. Positions 5-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini3 – 116114Response regulatoryPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 response regulatory domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0745.
    HOGENOMiHOG000034819.
    OMAiMRASYPD.
    OrthoDBiEOG6G4VQG.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view]
    SMARTiSM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52172. SSF52172. 1 hit.
    PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5IVE2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVQCLVVDDD PRILNYIASH LQTEHIDAYT QPSGEAALKL LEKQRVDIAV    50
    VDIMMDGMDG FQLCNTLKND YDIPVIMLTA RDALSDKERA FISGTDDYVT 100
    KPFEVKELIF RIRAVLRRYN INSNSEMTIG NLTLNQSYLE LQVSNKTMTL 150
    PNKEFQLLFM LAARPKQIFT REQIIEKIWG YDYEGDERTV DVHIKRLRQR 200
    LKKLNATLTI ETVRGQGYKV ENHV 224
    Length:224
    Mass (Da):25,946
    Last modified:June 26, 2007 - v1
    Checksum:i251BF68572E9155A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000703 Genomic DNA. Translation: ABQ50165.1.
    RefSeqiYP_001247741.1. NC_009487.1.

    Genome annotation databases

    EnsemblBacteriaiABQ50165; ABQ50165; SaurJH9_2385.
    GeneIDi5169102.
    KEGGisaj:SaurJH9_2385.
    PATRICi19542773. VBIStaAur42398_2525.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000703 Genomic DNA. Translation: ABQ50165.1 .
    RefSeqi YP_001247741.1. NC_009487.1.

    3D structure databases

    ProteinModelPortali A5IVE2.
    SMRi A5IVE2. Positions 5-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 359786.SaurJH9_2385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ50165 ; ABQ50165 ; SaurJH9_2385 .
    GeneIDi 5169102.
    KEGGi saj:SaurJH9_2385.
    PATRICi 19542773. VBIStaAur42398_2525.

    Phylogenomic databases

    eggNOGi COG0745.
    HOGENOMi HOG000034819.
    OMAi MRASYPD.
    OrthoDBi EOG6G4VQG.

    Enzyme and pathway databases

    BioCyci SAUR359786:GJEM-2468-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR001867. Sig_transdc_resp-reg_C.
    IPR001789. Sig_transdc_resp-reg_receiver.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00072. Response_reg. 1 hit.
    PF00486. Trans_reg_C. 1 hit.
    [Graphical view ]
    SMARTi SM00448. REC. 1 hit.
    SM00862. Trans_reg_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52172. SSF52172. 1 hit.
    PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
      US DOE Joint Genome Institute
      Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
      , Kim E., Tomasz A., Richardson P.
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JH9.

    Entry informationi

    Entry nameiHSSR_STAA9
    AccessioniPrimary (citable) accession number: A5IVE2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3