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A5IVE2 (HSSR_STAA9) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heme response regulator HssR
Gene names
Name:hssR
Ordered Locus Names:SaurJH9_2385
OrganismStaphylococcus aureus (strain JH9) [Complete proteome] [HAMAP]
Taxonomic identifier359786 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesStaphylococcus

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood By similarity.

Subcellular location

Cytoplasm Potential.

Post-translational modification

Phosphorylated by HssS By similarity.

Sequence similarities

Contains 1 response regulatory domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
Two-component regulatory system
Virulence
   Cellular componentCytoplasm
   LigandDNA-binding
   Molecular functionActivator
   PTMPhosphoprotein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

regulation of transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphorelay response regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224Heme response regulator HssR
PRO_0000331322

Regions

Domain3 – 116114Response regulatory

Amino acid modifications

Modified residue5214-aspartylphosphate By similarity

Sequences

Sequence LengthMass (Da)Tools
A5IVE2 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: 251BF68572E9155A

FASTA22425,946
        10         20         30         40         50         60 
MVQCLVVDDD PRILNYIASH LQTEHIDAYT QPSGEAALKL LEKQRVDIAV VDIMMDGMDG 

        70         80         90        100        110        120 
FQLCNTLKND YDIPVIMLTA RDALSDKERA FISGTDDYVT KPFEVKELIF RIRAVLRRYN 

       130        140        150        160        170        180 
INSNSEMTIG NLTLNQSYLE LQVSNKTMTL PNKEFQLLFM LAARPKQIFT REQIIEKIWG 

       190        200        210        220 
YDYEGDERTV DVHIKRLRQR LKKLNATLTI ETVRGQGYKV ENHV 

« Hide

References

[1]"Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Tomasz A., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JH9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000703 Genomic DNA. Translation: ABQ50165.1.
RefSeqYP_001247741.1. NC_009487.1.

3D structure databases

ProteinModelPortalA5IVE2.
SMRA5IVE2. Positions 5-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING359786.SaurJH9_2385.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ50165; ABQ50165; SaurJH9_2385.
GeneID5169102.
KEGGsaj:SaurJH9_2385.
PATRIC19542773. VBIStaAur42398_2525.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0745.
HOGENOMHOG000034819.
OMAMRASYPD.
OrthoDBEOG6G4VQG.

Enzyme and pathway databases

BioCycSAUR359786:GJEM-2468-MONOMER.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMSSF52172. SSF52172. 1 hit.
PROSITEPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHSSR_STAA9
AccessionPrimary (citable) accession number: A5IVE2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 26, 2007
Last modified: May 14, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families