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Protein

Probable molybdenum cofactor guanylyltransferase

Gene

mobA

Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.UniRule annotation

Catalytic activityi

GTP + molybdenum cofactor = diphosphate + guanylyl molybdenum cofactor.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei18GTPUniRule annotation1
Binding sitei65GTPUniRule annotation1
Metal bindingi97MagnesiumUniRule annotation1
Binding sitei97GTPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi6 – 8GTPUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processMolybdenum cofactor biosynthesis
LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable molybdenum cofactor guanylyltransferaseUniRule annotation (EC:2.7.7.77UniRule annotation)
Short name:
MoCo guanylyltransferaseUniRule annotation
Alternative name(s):
GTP:molybdopterin guanylyltransferaseUniRule annotation
Mo-MPT guanylyltransferaseUniRule annotation
Molybdopterin guanylyltransferaseUniRule annotation
Molybdopterin-guanine dinucleotide synthaseUniRule annotation
Short name:
MGD synthaseUniRule annotation
Gene namesi
Name:mobAUniRule annotation
Ordered Locus Names:SaurJH9_2294
OrganismiStaphylococcus aureus (strain JH9)
Taxonomic identifieri359786 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000791171 – 199Probable molybdenum cofactor guanylyltransferaseAdd BLAST199

Structurei

3D structure databases

ProteinModelPortaliA5IV51
SMRiA5IV51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.UniRule annotation

Sequence similaritiesi

Belongs to the MobA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000280425
KOiK03752
OMAiSVCYVQA

Family and domain databases

CDDicd02503 MobA, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00316 MobA, 1 hit
InterProiView protein in InterPro
IPR025877 MobA-like_NTP_Trfase
IPR013482 Molybde_CF_guanTrfase
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF12804 NTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit

Sequencei

Sequence statusi: Complete.

A5IV51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAIILAGGH SVRFGKPKAF AEVNGETFYS RVIKTLESTN MFNEIIISTN
60 70 80 90 100
AQLATQFKYP NVVIDDENHN DKGPLAGIYT IMKQHPEEEL FFVVSVDTPM
110 120 130 140 150
ITGKAVSTLY QFLVSHLIEN HLDVAAFKED GRFIPTIAFY SPNALGAITK
160 170 180 190
ALHSDNYSFK NIYHELSTDY LDVRDVDAPS YWYKNINYQH DLDALIQKL
Length:199
Mass (Da):22,556
Last modified:June 26, 2007 - v1
Checksum:iC79B67072F3321B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA Translation: ABQ50074.1
RefSeqiWP_000643986.1, NC_009487.1

Genome annotation databases

EnsemblBacteriaiABQ50074; ABQ50074; SaurJH9_2294
KEGGisaj:SaurJH9_2294

Entry informationi

Entry nameiMOBA_STAA9
AccessioniPrimary (citable) accession number: A5IV51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 26, 2007
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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