Skip Header

Contribute Send feedback
Read comments (?) or add your own

A5IUU9 (MTLD_STAA9) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:SaurJH9_2191
OrganismStaphylococcus aureus (strain JH9) [Complete proteome] [HAMAP]
Taxonomic identifier359786 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length368 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 368368Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000077685

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
A5IUU9 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: 3A6FC0F3984E46ED

FASTA36840,936
        10         20         30         40         50         60 
MKAVHFGAGN IGRGFIGYIL ADNNVKVTFA DVNEEIINAL AHDHQYDVIL ADESKTTTRV 

        70         80         90        100        110        120 
NNVDAINSMQ PSEALKQAIL EADIITTAVG VNILPIIAKS FAPFLKEKTN HVNIVACENA 

       130        140        150        160        170        180 
IMATDTLKKA VLDITGPLGN NIHFANSAVD RIVPLQKNEN ILDVMVEPFY EWVVEKDAWY 

       190        200        210        220        230        240 
GPELNHIKYV DDLTPYIERK LLTVNTGHAY LAYAGKFAGK ATVLDAVKDS SIEAGLRRVL 

       250        260        270        280        290        300 
AETSQYITNE FDFTEAEQAG YVEKIIDRFN NSYLSDEVTR VGRGTLRKIG PKDRIIKPLT 

       310        320        330        340        350        360 
YLYNKDLERT GLLNTAALLL KYDDTADQET VEKNNYIKEH GLKAFLSEYA KVDDGLADEI 


IEAYNSLS

« Hide

References

[1]"Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Tomasz A., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JH9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000703 Genomic DNA. Translation: ABQ49972.1.
RefSeqYP_001247548.1. NC_009487.1.

3D structure databases

ProteinModelPortalA5IUU9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5IUU9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000018719; EBSTAP00000018138; EBSTAG00000018718.
GeneID5167906.
GenomeReviewsGene locus SaurJH9_2191 in contig CP000703_GR.
KEGGsaj:SaurJH9_2191.
PATRIC19542327. VBIStaAur42398_2311.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0246.
GeneTreeEBGT00050000024485.
HOGENOMHBG568825.
OMAFANTAVD.
ProtClustDBPRK02318.

Enzyme and pathway databases

BioCycSAUR359786:SAURJH9_2191-MONOMER.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR023027. Mannitol_DH_CS.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_STAA9
AccessionPrimary (citable) accession number: A5IUU9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 26, 2007
Last modified: January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents