A5IUL7 (ACPS_STAA9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Holo-[acyl-carrier-protein] synthase
Short name=Holo-ACP synthase
EC=2.7.8.7

Alternative name(s):
4'-phosphopantetheinyl transferase AcpS

Gene names

Name:	acpS
Ordered Locus Names:	SaurJH9_2108

Organism

Staphylococcus aureus (strain JH9) [Complete proteome] [HAMAP]

Taxonomic identifier

359786 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	119 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein By similarity. HAMAP MF_00101
Catalytic activity	CoA-(4'-phosphopantetheine) + apo-[acyl-carrier-protein] = adenosine 3',5'-bisphosphate + holo-[acyl-carrier-protein]. HAMAP MF_00101
Cofactor	Magnesium By similarity. HAMAP MF_00101
Subcellular location	Cytoplasm By similarity HAMAP MF_00101.
Sequence similarities	Belongs to the P-Pant transferase superfamily. AcpS family.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Lipid synthesis
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW macromolecule biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	holo-[acyl-carrier-protein] synthase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 119	119	Holo-[acyl-carrier-protein] synthase HAMAP MF_00101		PRO_1000075665
Sites
	Metal binding	8	1	Magnesium By similarity
	Metal binding	59	1	Magnesium By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5IUL7 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: E2EF3C5A696E7DD2	FASTA	119	13,634
	10 20 30 40 50 60 MIHGIGVDLI EIDRIKVLYS KQPKLVERIL TKNEQHKFNN FTHEQRKIEF LAGRFATKEA 70 80 90 100 110 FSKALGTGLG KHVAFNDIDC YNDELGKPKI DYEGFIVHVS ISHTEHYAMS QVVLEKSAF

References

[1]

"Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Tomasz A., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JH9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000703 Genomic DNA. Translation: ABQ49890.1.
RefSeq	YP_001247466.1. NC_009487.1.
3D structure databases
ProteinModelPortal	A5IUL7.
ModBase	Search...
Protein-protein interaction databases
STRING	A5IUL7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000018799; EBSTAP00000018218; EBSTAG00000018798.
GeneID	5167670.
GenomeReviews	Gene locus SaurJH9_2108 in contig CP000703_GR.
KEGG	saj:SaurJH9_2108.
PATRIC	19542155. VBIStaAur42398_2225.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0736.
GeneTree	EBGT00050000025046.
HOGENOM	HBG734479.
OMA	VHVSITH.
ProtClustDB	PRK00070.
Enzyme and pathway databases
BioCyc	SAUR359786:SAURJH9_2108-MONOMER.
Family and domain databases
HAMAP	MF_00101. AcpS. [Tree]
InterPro	IPR008278. 4-PPantetheinyl_Trfase. IPR002582. ACPS. IPR004568. PPantethiene-prot_Trfase. [Graphical view]
Gene3D	G3DSA:3.90.470.20. G3DSA:3.90.470.20. 1 hit.
KO	K00997.
Pfam	PF01648. ACPS. 1 hit. [Graphical view]
ProDom	PD004282. PPantethiene-prot_Trfase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF56214. 4-PPT_transf. 1 hit.
TIGRFAMs	TIGR00516. AcpS. 1 hit. TIGR00556. Pantethn_trn. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACPS_STAA9

Accession

Primary (citable) accession number: A5IUL7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 26, 2007
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program