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Protein

Sodium/proline symporter

Gene

putP

Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the sodium-dependent uptake of extracellular L-proline. Since most S.aureus strains are L-proline auxotrophs, this transporter may aid the bacterial persistence during an infection of tissues with low proline concentrations.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/proline symporter
Alternative name(s):
Proline permease
Gene namesi
Name:putP
Ordered Locus Names:SaurJH9_1957
OrganismiStaphylococcus aureus (strain JH9)
Taxonomic identifieri359786 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Transmembranei139 – 159HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei200 – 220HelicalSequence analysisAdd BLAST21
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Transmembranei286 – 306HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Transmembranei438 – 458HelicalSequence analysisAdd BLAST21
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003640951 – 512Sodium/proline symporterAdd BLAST512

Structurei

3D structure databases

ProteinModelPortaliA5IU69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000282935.
KOiK11928.
OMAiVHKFDLS.

Family and domain databases

CDDicd11475. SLC5sbd_PutP. 1 hit.
InterProiIPR011851. Na/Pro_symporter.
IPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PTHR11819:SF148. PTHR11819:SF148. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02121. Na_Pro_sym. 1 hit.
TIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5IU69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTMGTALSQ QVDANWQTYI MIAVYFLILI VIGFYGYKQA TGNLSEYMLG
60 70 80 90 100
GRSIGPYITA LSAGASDMSG WMIMGLPGSV YSTGLSAMWI TIGLTLGAYI
110 120 130 140 150
NYFVVAPRLR VYTELAGDAI TLPDFFKNRL NDKNNVLKII SGLIIVVFFT
160 170 180 190 200
LYTHSGFVSG GKLFESAFGL DYHFGLILVA FIVIFYTFFG GYLAVSITDF
210 220 230 240 250
FQGVIMLIAM VMVPIVAMMN LNGWGTFHDV AAMKPTNLNL FKGLSFIGII
260 270 280 290 300
SLFSWGLGYF GQPHIIVRFM SIKSHKMLPK ARRLGISWMA VGLLGAVAVG
310 320 330 340 350
LTGIAFVPAY HIKLEDPETL FIVMSQVLFH PLVGGFLLAA ILAAIMSTIS
360 370 380 390 400
SQLLVTSSSL TEDFYKLIRG EEKAKTHQKE FVMIGRLSVL VVAIVAIAIA
410 420 430 440 450
WNPNDTILNL VGNAWAGFGA SFSPLVLFAL YWKGLTRAGA VSGMVSGALV
460 470 480 490 500
VIVWIAWIKP LAHINEIFGL YEIIPGFIVS VIVTYVVSKL TKKPGAFVET
510
DLNKVRDIVR EK
Length:512
Mass (Da):55,976
Last modified:June 26, 2007 - v1
Checksum:iC0B4AC52311A96DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA. Translation: ABQ49742.1.
RefSeqiWP_000957020.1. NC_009487.1.

Genome annotation databases

EnsemblBacteriaiABQ49742; ABQ49742; SaurJH9_1957.
GeneIDi28380451.
KEGGisaj:SaurJH9_1957.
PATRICi19541836. VBIStaAur42398_2071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA. Translation: ABQ49742.1.
RefSeqiWP_000957020.1. NC_009487.1.

3D structure databases

ProteinModelPortaliA5IU69.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ49742; ABQ49742; SaurJH9_1957.
GeneIDi28380451.
KEGGisaj:SaurJH9_1957.
PATRICi19541836. VBIStaAur42398_2071.

Phylogenomic databases

HOGENOMiHOG000282935.
KOiK11928.
OMAiVHKFDLS.

Family and domain databases

CDDicd11475. SLC5sbd_PutP. 1 hit.
InterProiIPR011851. Na/Pro_symporter.
IPR001734. Na/solute_symporter.
[Graphical view]
PANTHERiPTHR11819. PTHR11819. 1 hit.
PTHR11819:SF148. PTHR11819:SF148. 1 hit.
PfamiPF00474. SSF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02121. Na_Pro_sym. 1 hit.
TIGR00813. sss. 1 hit.
PROSITEiPS50283. NA_SOLUT_SYMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPUTP_STAA9
AccessioniPrimary (citable) accession number: A5IU69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: June 26, 2007
Last modified: November 2, 2016
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.