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Protein

Aminomethyltransferase

Gene

gcvT

Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine.UniRule annotation

Catalytic activityi

[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

BioCyciSAUR359786:GJEM-1622-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AminomethyltransferaseUniRule annotation (EC:2.1.2.10UniRule annotation)
Alternative name(s):
Glycine cleavage system T proteinUniRule annotation
Gene namesi
Name:gcvTUniRule annotation
Ordered Locus Names:SaurJH9_1595
OrganismiStaphylococcus aureus (strain JH9)
Taxonomic identifieri359786 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcaceaeStaphylococcus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363AminomethyltransferasePRO_1000078596Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA5IT65.
SMRiA5IT65. Positions 5-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000239381.
KOiK00605.
OMAiLGWLVHL.
OrthoDBiEOG6T1WS5.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.

Sequencei

Sequence statusi: Complete.

A5IT65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSDLKQTPL YQNYVDRGAK IVEFGGWAMP VQFSSIKEEH NAVRYEIGLF
60 70 80 90 100
DVSHMGEIEV TGKDASQFVQ YLLSNDTDNL TTSKALYTAL CNEEGGIIDD
110 120 130 140 150
LVIYKLADDN YLLVVNAANT EKDFNWILKH KEKFDVEVQN VSNQYGQLAI
160 170 180 190 200
QGPKARDLIN QLVDEDVTEM KMFEFKQGVK LFGANVILSQ SGYTGEDGFE
210 220 230 240 250
IYCNIDDTEK IWDGLLEYNV MPCGLGARDT LRLEAGLPLH GQDLTESITP
260 270 280 290 300
YEGGIAFASK PLIDADFIGK SVLKDQKENG APRRTVGLEL LEKGIARTGY
310 320 330 340 350
EVMDLDGNII GEVTSGTQSP SSGKSIALAM IKRDEFEMGR ELLVQVRKRQ
360
LKAKIVKKNQ IDK
Length:363
Mass (Da):40,458
Last modified:June 26, 2007 - v1
Checksum:iC70F4B160FFD6CBE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA. Translation: ABQ49388.1.
RefSeqiWP_000093349.1. NC_009487.1.

Genome annotation databases

EnsemblBacteriaiABQ49388; ABQ49388; SaurJH9_1595.
KEGGisaj:SaurJH9_1595.
PATRICi19540992. VBIStaAur42398_1686.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA. Translation: ABQ49388.1.
RefSeqiWP_000093349.1. NC_009487.1.

3D structure databases

ProteinModelPortaliA5IT65.
SMRiA5IT65. Positions 5-347.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ49388; ABQ49388; SaurJH9_1595.
KEGGisaj:SaurJH9_1595.
PATRICi19540992. VBIStaAur42398_1686.

Phylogenomic databases

HOGENOMiHOG000239381.
KOiK00605.
OMAiLGWLVHL.
OrthoDBiEOG6T1WS5.

Enzyme and pathway databases

BioCyciSAUR359786:GJEM-1622-MONOMER.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
HAMAPiMF_00259. GcvT.
InterProiIPR006223. GCS_T.
IPR022903. GCS_T_bac.
IPR028896. GCST/DmdA.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PANTHERiPTHR13847:SF5. PTHR13847:SF5. 1 hit.
PfamiPF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
PIRSFiPIRSF006487. GcvT. 1 hit.
SUPFAMiSSF101790. SSF101790. 1 hit.
TIGRFAMsiTIGR00528. gcvT. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., Tomasz A., Richardson P.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JH9.

Entry informationi

Entry nameiGCST_STAA9
AccessioniPrimary (citable) accession number: A5IT65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 26, 2007
Last modified: March 16, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.