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A5IT64

- GCSPA_STAA9

UniProt

A5IT64 - GCSPA_STAA9

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, SaurJH9_1594
Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciSAUR359786:GJEM-1621-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:SaurJH9_1594
OrganismiStaphylococcus aureus (strain JH9)
Taxonomic identifieri359786 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001984: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000083226Add
BLAST

Proteomic databases

PRIDEiA5IT64.

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi359786.SaurJH9_1594.

Structurei

3D structure databases

ProteinModelPortaliA5IT64.
SMRiA5IT64. Positions 4-446.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiRLVGQTE.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A5IT64-1 [UniParc]FASTAAdd to Basket

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MSHRYIPLTE KDKQEMLQTI GAKSIGELFG DVPSDILLNR DLNIAEGEAE    50
TTLLRRLNRI ASKNITKETH TSFLGAGVYD HYAPSVVDAM ISRSEFYTAY 100
TPYQPEISQG ELQAIFEFQT LICELTDMDV ANSSMYDGMT SFAEACILAF 150
SQTKKNKIVV SKGLHYQALQ VLHTYAKTRK EFEVVEIDLD GTVTDLKKLE 200
AAVDDETAAV AVQYPNFYGS IEDLEKIQSF IEDKKALFIV YANPLALGLL 250
TPPGSFGADI VVGDTQPFGI PAQFGGPHCG YFATTKKLMR KVPGRLVGQT 300
QDDEGNRGFV LTLQAREQHI RRDKATSNIC SNQALNALAS SIAMSALGKQ 350
GIYDIAVQNI EHANYAKQQF IKKGFEVLDG TSFNEFVVKF DKPIQQVNEE 400
LVKYNIIGGF DLGVVSDDFK NHMLIAVTEL RTKDEIDTFV EKAGELND 448
Length:448
Mass (Da):49,707
Last modified:June 26, 2007 - v1
Checksum:i94EE79F2F967472F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000703 Genomic DNA. Translation: ABQ49387.1.
RefSeqiYP_001246963.1. NC_009487.1.

Genome annotation databases

EnsemblBacteriaiABQ49387; ABQ49387; SaurJH9_1594.
GeneIDi5168924.
KEGGisaj:SaurJH9_1594.
PATRICi19540990. VBIStaAur42398_1685.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000703 Genomic DNA. Translation: ABQ49387.1 .
RefSeqi YP_001246963.1. NC_009487.1.

3D structure databases

ProteinModelPortali A5IT64.
SMRi A5IT64. Positions 4-446.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 359786.SaurJH9_1594.

Proteomic databases

PRIDEi A5IT64.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ49387 ; ABQ49387 ; SaurJH9_1594 .
GeneIDi 5168924.
KEGGi saj:SaurJH9_1594.
PATRICi 19540990. VBIStaAur42398_1685.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi RLVGQTE.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci SAUR359786:GJEM-1621-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., Tomasz A., Richardson P.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JH9.

Entry informationi

Entry nameiGCSPA_STAA9
AccessioniPrimary (citable) accession number: A5IT64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 26, 2007
Last modified: September 3, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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