A5ISV4 (MSRB_STAA9) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	SaurJH9_1483

Organism

Staphylococcus aureus (strain JH9) [Complete proteome] [HAMAP]

Taxonomic identifier

359786 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_1000087343
Sites
	Active site	114	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5ISV4 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 8B8DCB230D859AAD	FASTA	142	16,263
	10 20 30 40 50 60 MLKKDKSELT DIEYIVTQEN GTEPPFMNEY WNHFAKGIYV DKISGKPLFT SEEKFHSECG 70 80 90 100 110 120 WPSFSKALDD DEIIELVDKS FGMVRTEVRS EESNSHLGHV FNDGPKESGG LRYCINSAAI 130 140 QFIPYEKLEE LGYGDLISHF DK

References

[1]

"Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. , Kim E., Tomasz A., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JH9.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000703 Genomic DNA. Translation: ABQ49277.1.
RefSeq	YP_001246853.1. NC_009487.1.
3D structure databases
ProteinModelPortal	A5ISV4.
SMR	A5ISV4. Positions 9-142.
ModBase	Search...
Protein-protein interaction databases
STRING	A5ISV4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBSTAT00000019201; EBSTAP00000018620; EBSTAG00000019200.
GeneID	5168777.
GenomeReviews	Gene locus SaurJH9_1483 in contig CP000703_GR.
KEGG	saj:SaurJH9_1483.
PATRIC	19540756. VBIStaAur42398_1568.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0229.
GeneTree	EBGT00050000024012.
HOGENOM	HBG715255.
OMA	FTDGPVD.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	SAUR359786:SAURJH9_1483-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_STAA9

Accession

Primary (citable) accession number: A5ISV4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	June 26, 2007
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program