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A5IS68 (MRAY_STAA9) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:SaurJH9_1241
OrganismStaphylococcus aureus (strain JH9) [Complete proteome] [HAMAP]
Taxonomic identifier359786 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Bacillales › Staphylococcus ›

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP-Rule MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP-Rule MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00038

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 321321Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP-Rule MF_00038
PRO_1000074565

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane50 – 7021Helical; Potential
Transmembrane76 – 9621Helical; Potential
Transmembrane112 – 13221Helical; Potential
Transmembrane140 – 16021Helical; Potential
Transmembrane176 – 19621Helical; Potential
Transmembrane200 – 22021Helical; Potential
Transmembrane225 – 24521Helical; Potential
Transmembrane250 – 27021Helical; Potential
Transmembrane300 – 32021Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A5IS68 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: 0A2F82D042255848

FASTA32135,232
        10         20         30         40         50         60 
MIFVYALLAL VITFVLVPVL IPTLKRMKFG QSIREEGPQS HMKKTGTPTM GGLTFLLSIV 

        70         80         90        100        110        120 
ITSLVAIIFV DQANPIILLL FVTIGFGLIG FIDDYIIVVK KNNQGLTSKQ KFLAQIGIAI 

       130        140        150        160        170        180 
IFFVLSNVFH LVNFSTSIHI PFTNVAIPLS FAYVIFIVFW QVGFSNAVNL TDGLDGLATG 

       190        200        210        220        230        240 
LSIIGFTMYA IMSFVLGETA IGIFCIIMLF ALLGFLPYNI NPAKVFMGDT GSLALGGIFA 

       250        260        270        280        290        300 
TISIMLNQEL SLIFIGLVFV IETLSVMLQV ASFKLTGKRI FKMSPIHHHF ELIGWSEWKV 

       310        320 
VTVFWAVGLI SGLIGLWIGV H

« Hide

References

[1]"Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Tomasz A., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JH9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000703 Genomic DNA. Translation: ABQ49041.1.
RefSeqYP_001246617.1. NC_009487.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING359786.SaurJH9_1241.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ49041; ABQ49041; SaurJH9_1241.
GeneID5167834.
KEGGsaj:SaurJH9_1241.
PATRIC19540259. VBIStaAur42398_1320.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0472.
HOGENOMHOG000275124.
KOK01000.
OMAEYLTQFY.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycSAUR359786:GJEM-1269-MONOMER.
UniPathwayUPA00219.

Family and domain databases

HAMAPMF_00038. MraY.
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
PANTHERPTHR22926. PTHR22926. 1 hit.
PTHR22926:SF3. PTHR22926:SF3. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. mraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBA5IS68.

Entry information

Entry nameMRAY_STAA9
AccessionPrimary (citable) accession number: A5IS68
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 26, 2007
Last modified: May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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