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A5IQL2

- GRAR_STAA9

UniProt

A5IQL2 - GRAR_STAA9

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Protein
Response regulator protein GraR
Gene
graR, SaurJH9_0682
Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs) By similarity.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. phosphorelay response regulator activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. response to antibiotic Source: UniProtKB-KW
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Antibiotic resistance, Transcription, Transcription regulation, Two-component regulatory system, Virulence

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciSAUR359786:GJEM-705-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Response regulator protein GraR
Alternative name(s):
Glycopeptide resistance-associated protein R
Gene namesi
Name:graR
Ordered Locus Names:SaurJH9_0682
OrganismiStaphylococcus aureus (strain JH9)
Taxonomic identifieri359786 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001984: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Response regulator protein GraR
PRO_0000347898Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei51 – 5114-aspartylphosphate By similarity

Post-translational modificationi

Phosphorylated by GraS By similarity.

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi359786.SaurJH9_0682.

Structurei

3D structure databases

ProteinModelPortaliA5IQL2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 115114Response regulatory
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0745.
HOGENOMiHOG000034819.
KOiK11630.
OMAiMAGESIT.
OrthoDBiEOG6G4VQG.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view]
SMARTiSM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view]
SUPFAMiSSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEiPS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5IQL2-1 [UniParc]FASTAAdd to Basket

« Hide

MQILLVEDDN TLFQELKKEL EQWDFNVAGI EDFGKVMDTF ESFNPEIVIL    50
DVQLPKYDGF YWCRKMREVS NVPILFLSSR DNPMDQVMSM ELGADDYMQK 100
PFYTNVLIAK LQAIYRRVYE FTAEEKRTLT WQDAVVDLSK DSIQKGDDTI 150
FLSKTEMIIL EILITKKNQI VSRDTIITAL WDDEAFVSDN TLTVNVNRLR 200
KKLSEISMDS AIETKVGKGY MAHE 224
Length:224
Mass (Da):26,066
Last modified:June 26, 2007 - v1
Checksum:i4A636CBAA6FAD233
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000703 Genomic DNA. Translation: ABQ48485.1.
RefSeqiYP_001246061.1. NC_009487.1.

Genome annotation databases

EnsemblBacteriaiABQ48485; ABQ48485; SaurJH9_0682.
GeneIDi5168976.
KEGGisaj:SaurJH9_0682.
PATRICi19539089. VBIStaAur42398_0736.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000703 Genomic DNA. Translation: ABQ48485.1 .
RefSeqi YP_001246061.1. NC_009487.1.

3D structure databases

ProteinModelPortali A5IQL2.
ModBasei Search...

Protein-protein interaction databases

STRINGi 359786.SaurJH9_0682.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ48485 ; ABQ48485 ; SaurJH9_0682 .
GeneIDi 5168976.
KEGGi saj:SaurJH9_0682.
PATRICi 19539089. VBIStaAur42398_0736.

Phylogenomic databases

eggNOGi COG0745.
HOGENOMi HOG000034819.
KOi K11630.
OMAi MAGESIT.
OrthoDBi EOG6G4VQG.

Enzyme and pathway databases

BioCyci SAUR359786:GJEM-705-MONOMER.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR011006. CheY-like_superfamily.
IPR001867. Sig_transdc_resp-reg_C.
IPR016032. Sig_transdc_resp-reg_C-effctor.
IPR001789. Sig_transdc_resp-reg_receiver.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00072. Response_reg. 1 hit.
PF00486. Trans_reg_C. 1 hit.
[Graphical view ]
SMARTi SM00448. REC. 1 hit.
SM00862. Trans_reg_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46894. SSF46894. 1 hit.
SSF52172. SSF52172. 1 hit.
PROSITEi PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., Tomasz A., Richardson P.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JH9.

Entry informationi

Entry nameiGRAR_STAA9
AccessioniPrimary (citable) accession number: A5IQL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 26, 2007
Last modified: May 14, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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