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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Staphylococcus aureus (strain JH9)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei176 – 1761May be catalytically importantUniRule annotation

GO - Molecular functioni

  1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciSAUR359786:GJEM-612-MONOMER.
UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:SaurJH9_0589
OrganismiStaphylococcus aureus (strain JH9)
Taxonomic identifieri359786 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesStaphylococcus
ProteomesiUP000001984: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292GTP cyclohydrolase FolE2PRO_1000087583Add
BLAST

Proteomic databases

PRIDEiA5IQC0.

Interactioni

Protein-protein interaction databases

STRINGi359786.SaurJH9_0589.

Structurei

3D structure databases

ProteinModelPortaliA5IQC0.
SMRiA5IQC0. Positions 47-290.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.

Sequencei

Sequence statusi: Complete.

A5IQC0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEFDLSTRE GRWKHFGSVD PIEGTKPTTK NEMTDLQSTH KDFLFEIEEV
60 70 80 90 100
GIKNLVYPVL VDQYQTAGTF SFSTSLTKDE KGINMSRIIE SVEKHYDNGI
110 120 130 140 150
ELEFNTLYQV LRTLQTNMKQ NAAGVDVSGK WFFDRYSPTT NIKAVGNADV
160 170 180 190 200
TYGLAIDGDK VTRKELTIEA TVTTLCPCSK EISEYSAHNQ RGVVTVKTYI
210 220 230 240 250
NKDQNIVDDY KNKILDAMEA NASSILYPIL KRPDEKRVTE RAYENPRFVE
260 270 280 290
DLIRLIAADL VEFDWLDGFD IECRNEESIH QHDAFAKLKY RK
Length:292
Mass (Da):33,481
Last modified:June 26, 2007 - v1
Checksum:i78EAF10A9A42553B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA. Translation: ABQ48393.1.
RefSeqiYP_001245969.1. NC_009487.1.

Genome annotation databases

EnsemblBacteriaiABQ48393; ABQ48393; SaurJH9_0589.
GeneIDi5167488.
KEGGisaj:SaurJH9_0589.
PATRICi19538899. VBIStaAur42398_0641.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000703 Genomic DNA. Translation: ABQ48393.1.
RefSeqiYP_001245969.1. NC_009487.1.

3D structure databases

ProteinModelPortaliA5IQC0.
SMRiA5IQC0. Positions 47-290.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi359786.SaurJH9_0589.

Proteomic databases

PRIDEiA5IQC0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ48393; ABQ48393; SaurJH9_0589.
GeneIDi5167488.
KEGGisaj:SaurJH9_0589.
PATRICi19538899. VBIStaAur42398_0641.

Phylogenomic databases

eggNOGiCOG1469.
HOGENOMiHOG000280679.
KOiK09007.
OMAiGAHNQRG.
OrthoDBiEOG6X6RBH.

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.
BioCyciSAUR359786:GJEM-612-MONOMER.

Family and domain databases

HAMAPiMF_01527_B. GTP_cyclohydrol_B.
InterProiIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamiPF02649. GCHY-1. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00294. TIGR00294. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.
    , Kim E., Tomasz A., Richardson P.
    Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JH9.

Entry informationi

Entry nameiGCH4_STAA9
AccessioniPrimary (citable) accession number: A5IQC0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 26, 2007
Last modified: January 7, 2015
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.