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A5IPC4 (A5IPC4_STAA9) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 2 HAMAP MF_00108
EC=2.7.7.60 HAMAP MF_00108
Alternative name(s):
4-diphosphocytidyl-2C-methyl-D-erythritol synthase 2 HAMAP MF_00108
MEP cytidylyltransferase 2 HAMAP MF_00108
Gene names
Name:ispD2 HAMAP MF_00108
Ordered Locus Names:SaurJH9_0240
OrganismStaphylococcus aureus (strain JH9) [Complete proteome] [HAMAP] EMBL ABQ48047.1
Taxonomic identifier359786 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length238 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) By similarity. HAMAP MF_00108 SAAS SAAS018294

Catalytic activity

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol. HAMAP MF_00108 SAAS SAAS018294

Pathway

Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6. HAMAP MF_00108 SAAS SAAS018294

Sequence similarities

Belongs to the IspD family. HAMAP MF_00108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Site141Transition state stabilizer By similarity HAMAP MF_00108
Site221Transition state stabilizer By similarity HAMAP MF_00108
Site1601Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108
Site2171Positions MEP for the nucleophilic attack By similarity HAMAP MF_00108

Sequences

Sequence LengthMass (Da)Tools
A5IPC4 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: B19F7EA82D847A0F

FASTA23826,657
        10         20         30         40         50         60 
MKYAGILAGG IGSRMGNVPL PKQFLDLDNK PILIHTLEKF ILINDFEKII IATPQQWMTH 

        70         80         90        100        110        120 
TKDTLRKFKI SDERIEVIQG GSDRNDTIMN IVKHIESTNG INDDDVIVTH DAVRPFLTHR 

       130        140        150        160        170        180 
IIKENIQAAL EYGAVDTVID AIDTIVTSKD NQTIDAIPVR NEMYQGQTPQ SFNINLLKES 

       190        200        210        220        230 
YAQLSDEQKS ILSDACKIIV ETNKPVRLVK GELYNIKVTT PYDLKVANAI IRGGIADD

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References

[1]"Complete sequence of chromosome of Staphylococcus aureus subsp. aureus JH9."
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina del Rio T., Hammon N., Israni S., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N. expand/collapse author list , Kim E., Tomasz A., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JH9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000703 Genomic DNA. Translation: ABQ48047.1.
RefSeqYP_001245623.1. NC_009487.1.

3D structure databases

ProteinModelPortalA5IPC4.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5IPC4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBSTAT00000018638; EBSTAP00000018057; EBSTAG00000018637.
GeneID5169596.
GenomeReviewsGene locus SaurJH9_0240 in contig CP000703_GR.
KEGGsaj:SaurJH9_0240.
PATRIC19538146. VBIStaAur42398_0284.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1211.
GeneTreeEBGT00050000024510.
HOGENOMHBG672839.
OMAREQQDFW.
ProtClustDBPRK00155.

Enzyme and pathway databases

BioCycSAUR359786:SAURJH9_0240-MONOMER.

Family and domain databases

HAMAPMF_00108. IspD.
[Tree]
InterProIPR001228. ISPD_synthase.
IPR018294. ISPD_synthase_CS.
[Graphical view]
KOK00991.
PfamPF01128. IspD. 1 hit.
[Graphical view]
PROSITEPS01295. ISPD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameA5IPC4_STAA9
AccessionPrimary (citable) accession number: A5IPC4
Entry history
Integrated into UniProtKB/TrEMBL: June 26, 2007
Last sequence update: June 26, 2007
Last modified: December 14, 2011
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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