A5ILP7 (OGG1_THEP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable N-glycosylase/DNA lyase

Including the following 2 domains:

1. 8-oxoguanine DNA glycosylase
   EC=3.2.2.-
2. DNA-(apurinic or apyrimidinic site) lyase
   Short name=AP lyase
   EC=4.2.99.18

Gene names

Name:	ogg
Ordered Locus Names:	Tpet_1106

Organism

Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995) [Complete proteome] [HAMAP]

Taxonomic identifier

390874 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Thermotogae › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › Thermotoga petrophila

Protein attributes

Sequence length	207 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 7-oxoG) from DNA. Also nicks DNA at apurinic/apyrimidinic sites (AP sites) By similarity. HAMAP-Rule MF_00241
Catalytic activity	The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. HAMAP-Rule MF_00241
Sequence similarities	Belongs to the type-2 OGG1 family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Molecular function	Glycosidase Hydrolase Lyase
Technical term	Complete proteome Multifunctional enzyme
Gene Ontology (GO)
Biological_process	base-excision repair Inferred from electronic annotation. Source: HAMAP
Molecular_function	DNA-(apurinic or apyrimidinic site) lyase activity Inferred from electronic annotation. Source: HAMAP hydrolase activity, hydrolyzing N-glycosyl compounds Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 207	207	Probable N-glycosylase/DNA lyase HAMAP-Rule MF_00241		PRO_1000005711
Sites
	Active site	129	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5ILP7 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: DB4F7E3EF71C6204	FASTA	207	24,210
	10 20 30 40 50 60 MEELLKELER IREEAKPLVE QRFEEFKRLG EEGTEEDLFC ELSFCVLTAN WSAEGGIRAQ 70 80 90 100 110 120 KEIGKGFVHL PLEELAEKLR EVGHRYPQKR AEFIVENRKL LGKLKNLVKG DPFQSREFLV 130 140 150 160 170 180 RNAKGIGWKE ASHFLRNTGV EDLAILDKHV LRLMKRHGLI QEIPKGWSKK RYLYVEEILR 190 200 KVAEAFGESP GKFDLYLWYL VKGKVDK

References

[1]

"Complete sequence of Thermotoga petrophila RKU-1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RKU-1 / ATCC BAA-488 / DSM 13995.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000702 Genomic DNA. Translation: ABQ47120.1.
RefSeq	YP_001244696.1. NC_009486.1.
3D structure databases
ProteinModelPortal	A5ILP7.
ModBase	Search...
Protein-protein interaction databases
STRING	390874.Tpet_1106.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ47120; ABQ47120; Tpet_1106.
GeneID	5170013.
KEGG	tpt:Tpet_1106.
PATRIC	23945024. VBIThePet65348_1122.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1059.
HOGENOM	HOG000224507.
KO	K03653.
OMA	IIDRHIL.
ProtClustDB	PRK01229.
Family and domain databases
HAMAP	MF_00241. Ogg.
InterPro	IPR012092. DNA_glyclase/DNA_lyase_thermo. IPR011257. DNA_glycosylase. IPR003265. HhH-GPD_domain. [Graphical view]
Pfam	PF00730. HhH-GPD. 1 hit. [Graphical view]
PIRSF	PIRSF005954. Thrmst_ogg. 1 hit.
SMART	SM00478. ENDO3c. 1 hit. [Graphical view]
SUPFAM	SSF48150. DNA_glycsylse. 1 hit.
ProtoNet	Search...

Entry information

Entry name

OGG1_THEP1

Accession

Primary (citable) accession number: A5ILP7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 26, 2007
Last modified:	May 1, 2013
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program