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A5ILJ8 (FTHS_THEP1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:Tpet_1054
OrganismThermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995) [Complete proteome] [HAMAP]
Taxonomic identifier390874 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length542 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 542542Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_1000068799

Regions

Nucleotide binding53 – 608ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
A5ILJ8 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: E7AF395C77AFF3C8

FASTA54258,628
        10         20         30         40         50         60 
MKPIKEIADQ LGLKDDVLYP YGHYIAKIDH RFLKSLENRE DGKLILVTAV TPTPAGEGKT 

        70         80         90        100        110        120 
TTSIGLSMSL NRIGKKSIVT LREPSLGPTL GLKGGATGGG RSRVLPSDEI NLHFTGDMHA 

       130        140        150        160        170        180 
VASAHNLLAA VLDSHIKHGN ELKIDITRVF WKRTMDMNDR ALRSIVIGLG GSANGFPRED 

       190        200        210        220        230        240 
SFIITAASEV MAVLALSENM KDLKERLGKI IVALNTDRKI VRVSDLGIQG AMAVLLKDAI 

       250        260        270        280        290        300 
NPNLVQTTEG TPALIHCGPF ANIAHGTNSI IATKMAMKLS EYTVTEAGFG ADLGAEKFID 

       310        320        330        340        350        360 
FVSRVGGFYP NAAVLVATVR ALKYHGGADL KNIHEENLEA LKEGFKNLRV HLENLRKFNL 

       370        380        390        400        410        420 
PVVVALNRFI TDTEKEIAYV VKECEKLGVR VAVSEVFEKG SEGGVELAKA VTEAVKDVKP 

       430        440        450        460        470        480 
VYLYEMNDPV EKKIEILAKE IYRAGRVEFS DTAKNALKFI KKHGFDELPV IVAKTPKSIS 

       490        500        510        520        530        540 
HDPSLRGAPE GYTFVVSDLF VSAGAGFVVA LSGDINLMPG LPERPNALNM DVDDSGNIVG 


VS 

« Hide

References

[1]"Complete sequence of Thermotoga petrophila RKU-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RKU-1 / ATCC BAA-488 / DSM 13995.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000702 Genomic DNA. Translation: ABQ47071.1.
RefSeqYP_001244647.1. NC_009486.1.

3D structure databases

ProteinModelPortalA5ILJ8.
SMRA5ILJ8. Positions 1-540.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING390874.Tpet_1054.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ47071; ABQ47071; Tpet_1054.
GeneID5171228.
KEGGtpt:Tpet_1054.
PATRIC23944908. VBIThePet65348_1066.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycTPET390874:GHJI-1085-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_THEP1
AccessionPrimary (citable) accession number: A5ILJ8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 26, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways