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A5ILJ8

- FTHS_THEP1

UniProt

A5ILJ8 - FTHS_THEP1

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Protein

Formate--tetrahydrofolate ligase

Gene
fhs, Tpet_1054
Organism
Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi53 – 608ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciTPET390874:GHJI-1085-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:Tpet_1054
OrganismiThermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Taxonomic identifieri390874 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000006558: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 542542Formate--tetrahydrofolate ligaseUniRule annotationPRO_1000068799Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi390874.Tpet_1054.

Structurei

3D structure databases

ProteinModelPortaliA5ILJ8.
SMRiA5ILJ8. Positions 1-540.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5ILJ8-1 [UniParc]FASTAAdd to Basket

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MKPIKEIADQ LGLKDDVLYP YGHYIAKIDH RFLKSLENRE DGKLILVTAV    50
TPTPAGEGKT TTSIGLSMSL NRIGKKSIVT LREPSLGPTL GLKGGATGGG 100
RSRVLPSDEI NLHFTGDMHA VASAHNLLAA VLDSHIKHGN ELKIDITRVF 150
WKRTMDMNDR ALRSIVIGLG GSANGFPRED SFIITAASEV MAVLALSENM 200
KDLKERLGKI IVALNTDRKI VRVSDLGIQG AMAVLLKDAI NPNLVQTTEG 250
TPALIHCGPF ANIAHGTNSI IATKMAMKLS EYTVTEAGFG ADLGAEKFID 300
FVSRVGGFYP NAAVLVATVR ALKYHGGADL KNIHEENLEA LKEGFKNLRV 350
HLENLRKFNL PVVVALNRFI TDTEKEIAYV VKECEKLGVR VAVSEVFEKG 400
SEGGVELAKA VTEAVKDVKP VYLYEMNDPV EKKIEILAKE IYRAGRVEFS 450
DTAKNALKFI KKHGFDELPV IVAKTPKSIS HDPSLRGAPE GYTFVVSDLF 500
VSAGAGFVVA LSGDINLMPG LPERPNALNM DVDDSGNIVG VS 542
Length:542
Mass (Da):58,628
Last modified:June 26, 2007 - v1
Checksum:iE7AF395C77AFF3C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000702 Genomic DNA. Translation: ABQ47071.1.
RefSeqiYP_001244647.1. NC_009486.1.

Genome annotation databases

EnsemblBacteriaiABQ47071; ABQ47071; Tpet_1054.
GeneIDi5171228.
KEGGitpt:Tpet_1054.
PATRICi23944908. VBIThePet65348_1066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000702 Genomic DNA. Translation: ABQ47071.1 .
RefSeqi YP_001244647.1. NC_009486.1.

3D structure databases

ProteinModelPortali A5ILJ8.
SMRi A5ILJ8. Positions 1-540.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390874.Tpet_1054.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ47071 ; ABQ47071 ; Tpet_1054 .
GeneIDi 5171228.
KEGGi tpt:Tpet_1054.
PATRICi 23944908. VBIThePet65348_1066.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci TPET390874:GHJI-1085-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RKU-1 / ATCC BAA-488 / DSM 13995.

Entry informationi

Entry nameiFTHS_THEP1
AccessioniPrimary (citable) accession number: A5ILJ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 26, 2007
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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