A5IL29 (GCH4_THEP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase folE2
EC=3.5.4.16

Gene names

Name:	folE2
Ordered Locus Names:	Tpet_0884

Organism

Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995) [Complete proteome] [HAMAP]

Taxonomic identifier

390874 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Thermotogae › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga › Thermotoga petrophila

Protein attributes

Sequence length	259 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 259	259	GTP cyclohydrolase folE2 HAMAP-Rule MF_01527		PRO_1000068672
Sites
	Site	143	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5IL29 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 687D30FABCEC3430	FASTA	259	30,296
	10 20 30 40 50 60 MKDVQNEKDP RMVPLKKVGI KDLHWPLKVI LKEDGYQSTV AQISCSVDLH REKRGIHMSR 70 80 90 100 110 120 FIEVLNKLEV ITPQIFEEIL DDLIEIMEAK RAHLEIHFPY FTWKESPVSR KKSPLKVDCF 130 140 150 160 170 180 VEAEKEKNFS FKIGVRTPVH TLCPCSKEIS DYGAHNQRAF VEITVKTRKF IWFEDLVEIA 190 200 210 220 230 240 EKNASSPLYT LLKRPDEKFV TEKAYENPRF VEDVARDVAL KLEKDPRITW YRVYVESMES 250 IHNHNAFACV EKGDFVLEG

References

[1]

"Complete sequence of Thermotoga petrophila RKU-1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RKU-1 / ATCC BAA-488 / DSM 13995.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000702 Genomic DNA. Translation: ABQ46902.1.
RefSeq	YP_001244478.1. NC_009486.1.
3D structure databases
ProteinModelPortal	A5IL29.
ModBase	Search...
Protein-protein interaction databases
STRING	390874.Tpet_0884.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABQ46902; ABQ46902; Tpet_0884.
GeneID	5171715.
KEGG	tpt:Tpet_0884.
PATRIC	23944560. VBIThePet65348_0893.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000280679.
KO	K09007.
OMA	INMYVDL.
ProtClustDB	PRK13674.
Enzyme and pathway databases
UniPathway	UPA00848; UER00151.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_B. GTP_cyclohydrol_B.
InterPro	IPR022838. GTP_cyclohydrolase_FolE2. IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00294. TIGR00294. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCH4_THEP1

Accession

Primary (citable) accession number: A5IL29

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	June 26, 2007
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program