A5IKL0 (GCST_THEP1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	Tpet_0713

Organism

Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995) [Complete proteome] [HAMAP]

Taxonomic identifier

390874 [NCBI]

Taxonomic lineage

Bacteria › Thermotogae › Thermotogales › Thermotogaceae › Thermotoga

Protein attributes

Sequence length	364 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 364	364	Aminomethyltransferase HAMAP MF_00259		PRO_1000047725

Sequences

	Sequence		Length	Mass (Da)
	A5IKL0 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 917DFA83DB98104A	FASTA	364	40,272
	10 20 30 40 50 60 MKRTPLFEKH VGLGAKMVDF AGWEMPLYYT SIFEEVMAVR KSVGMFDVSH MGEFLVKGPE 70 80 90 100 110 120 AVSFIDFLIT NDFSSLPDGK AIYSVMCNEN GGIIDDLVVY KVSPDEALMV VNAANIEKDF 130 140 150 160 170 180 NWIKSHSKNF DVEILNISDT TALIAFQGPE AQETLQELVE DSLEEIAYYS FRKSIVAGVE 190 200 210 220 230 240 ALVSRTGYTG EDGFELMLEA KDAPKVWDAL MNLLRKIDGR PAGLGARDVC RLEATYLLYG 250 260 270 280 290 300 QDMDESTNPL EVGLSWVVKL DKDFVGKEAL LKAKEKVERK LVALELSGKR IARKGYEVLK 310 320 330 340 350 360 NGERVGEITS GNFSPTLGKS IALALVSKSV KVGDQLEVAF PGGKLVEALV VKKPFYRGSV RREV

References

[1]

"Complete sequence of Thermotoga petrophila RKU-1." US DOE Joint Genome Institute Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. , Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P. Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: RKU-1 / ATCC BAA-488 / DSM 13995.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000702 Genomic DNA. Translation: ABQ46733.1.
RefSeq	YP_001244309.1. NC_009486.1.
3D structure databases
ProteinModelPortal	A5IKL0.
SMR	A5IKL0. Positions 1-362.
ModBase	Search...
Protein-protein interaction databases
STRING	A5IKL0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5170979.
GenomeReviews	Gene locus Tpet_0713 in contig CP000702_GR.
KEGG	tpt:Tpet_0713.
PATRIC	23944190. VBIThePet65348_0720.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0404.
HOGENOM	HBG299834.
OMA	VINASNK.
ProtClustDB	PRK00389.
Enzyme and pathway databases
BioCyc	TPET390874:TPET_0713-MONOMER.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_THEP1

Accession

Primary (citable) accession number: A5IKL0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 26, 2007
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program