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A5IKK7

- GCSPB_THEP1

UniProt

A5IKK7 - GCSPB_THEP1

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Protein
Probable glycine dehydrogenase (decarboxylating) subunit 2
Gene
gcvPB, Tpet_0710
Organism
Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciTPET390874:GHJI-726-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 2 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 2
Glycine decarboxylase subunit 2
Glycine dehydrogenase (aminomethyl-transferring) subunit 2
Gene namesi
Name:gcvPB
Ordered Locus Names:Tpet_0710
OrganismiThermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Taxonomic identifieri390874 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
ProteomesiUP000006558: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation
PRO_1000045708Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei262 – 2621N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi390874.Tpet_0710.

Structurei

3D structure databases

ProteinModelPortaliA5IKK7.
SMRiA5IKK7. Positions 2-473.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239368.
KOiK00283.
OMAiWTGLMMI.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00713. GcvPB.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

A5IKK7-1 [UniParc]FASTAAdd to Basket

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MTIFERSKKG RKAFRLPESD IPEYSLPNRF LRRTPPELPE VSEPDVVRHY    50
TDLARKNYSV DRGIYPLGSC TMKYNPKLNE KVANLEGFRE IHPYQPAETV 100
QGSLRLMYEL KEMLCEITGM DDMTLQPAAG AHGELTGMLI VREYFKSRGD 150
TGRKKVLVPD SAHGTNPASA SMVGFEVVEI KSKNGMVDVE DLKKLLDEEV 200
AAVMLTNPNT LGLFEKDILK IAEMTHECGA LLYYDGANLN AVMGKVRPGD 250
MGFDIVHLNL HKTFSTPHGM GGPGSGPVGV KKHLVDFLPF PQVRKNGELY 300
ELFVPEKTIG RVRSFFGNFP VLVKAYTYIL TMGRDGLERV SEMAVLNANY 350
LKKKIEKFLE IPYNGFCMHE FVASAEKVFR ETGVRTLDIA KRILDFGVHP 400
PTVYFPLIVL EALMIEPTET ENKETLDKYA EILERVVKEA YENPDVLKNA 450
PHNTPVRRVD EVLASKKPVF RWRG 474
Length:474
Mass (Da):53,530
Last modified:June 26, 2007 - v1
Checksum:i909C0B921F7CD7DF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000702 Genomic DNA. Translation: ABQ46730.1.
RefSeqiWP_011943314.1. NC_009486.1.
YP_001244306.1. NC_009486.1.

Genome annotation databases

EnsemblBacteriaiABQ46730; ABQ46730; Tpet_0710.
GeneIDi5170610.
KEGGitpt:Tpet_0710.
PATRICi23944184. VBIThePet65348_0717.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000702 Genomic DNA. Translation: ABQ46730.1 .
RefSeqi WP_011943314.1. NC_009486.1.
YP_001244306.1. NC_009486.1.

3D structure databases

ProteinModelPortali A5IKK7.
SMRi A5IKK7. Positions 2-473.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 390874.Tpet_0710.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ46730 ; ABQ46730 ; Tpet_0710 .
GeneIDi 5170610.
KEGGi tpt:Tpet_0710.
PATRICi 23944184. VBIThePet65348_0717.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239368.
KOi K00283.
OMAi WTGLMMI.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci TPET390874:GHJI-726-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00713. GcvPB.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR023012. GDC_P_su2.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RKU-1 / ATCC BAA-488 / DSM 13995.

Entry informationi

Entry nameiGCSPB_THEP1
AccessioniPrimary (citable) accession number: A5IKK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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