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Protein

Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO

Gene

trmFO

Organism
Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FADUniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 12FADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processtRNA processing
LigandFAD, Flavoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation (EC:2.1.1.74UniRule annotation)
Alternative name(s):
Folate-dependent tRNA (uracil-5-)-methyltransferaseUniRule annotation
Folate-dependent tRNA(M-5-U54)-methyltransferaseUniRule annotation
Gene namesi
Name:trmFOUniRule annotation
Ordered Locus Names:Tpet_0195
OrganismiThermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Taxonomic identifieri390874 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
Proteomesi
  • UP000006558 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003464171 – 435Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOAdd BLAST435

Interactioni

Protein-protein interaction databases

STRINGi390874.Tpet_0195

Structurei

3D structure databases

ProteinModelPortaliA5IJ51
SMRiA5IJ51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MnmG family. TrmFO subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QXI Bacteria
COG1206 LUCA
HOGENOMiHOG000252054
KOiK04094
OMAiRFGPMKP

Family and domain databases

Gene3Di3.50.50.602 hits
HAMAPiMF_01037 TrmFO, 1 hit
InterProiView protein in InterPro
IPR036188 FAD/NAD-bd_sf
IPR002218 MnmG-rel
IPR004417 TrmFO
PANTHERiPTHR11806 PTHR11806, 1 hit
PTHR11806:SF2 PTHR11806:SF2, 1 hit
PfamiView protein in Pfam
PF01134 GIDA, 1 hit
SUPFAMiSSF51905 SSF51905, 1 hit
TIGRFAMsiTIGR00137 gid_trmFO, 1 hit

Sequencei

Sequence statusi: Complete.

A5IJ51-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIVNVIGAGL AGSEVAYNLG KRGIRVRLFE MRPKKMTEVH KTGYFAELVC
60 70 80 90 100
SNSLKSEDIT NAEGLLKAEM KLMGSITLEA AEKARVPSGK ALAVDRNIFA
110 120 130 140 150
KEVTEAIESL ESVEVIREEV TEFDPEEGLW VVATGPATSD GLFSFLRNLL
160 170 180 190 200
GDDFLFFFDA VSPIVTFESI DMEHAFWGDR FGKGKDYINC PLTDGEYEEL
210 220 230 240 250
WKALVEAEVI EMEDFDRKLL FERCQPIEEI ARSGKDALRY GPLRPTGLVD
260 270 280 290 300
PRTGKEPYAV VQLRREDKEG RFYSLVGFQT RLKWNEQKRV LRKIPCLRNA
310 320 330 340 350
EIVRYGVMHR NVYINSPKLL DIFFRLKKQP NIFFAGQITG VEGYMESAAS
360 370 380 390 400
GIYVAYNVYR ILKGLSPLKL PEETMMGALF SYIIEKVEGD LKPMYANFGL
410 420 430
LPPLKTRVKD KFGKRKKLAE RAIEAMRKFL EEYPW
Length:435
Mass (Da):49,557
Last modified:June 26, 2007 - v1
Checksum:i969BD5B076202902
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000702 Genomic DNA Translation: ABQ46224.1
RefSeqiWP_011942878.1, NC_009486.1

Genome annotation databases

EnsemblBacteriaiABQ46224; ABQ46224; Tpet_0195
GeneIDi29652276
KEGGitpt:Tpet_0195

Similar proteinsi

Entry informationi

Entry nameiTRMFO_THEP1
AccessioniPrimary (citable) accession number: A5IJ51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 26, 2007
Last modified: February 28, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome