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A5IJ51

- TRMFO_THEP1

UniProt

A5IJ51 - TRMFO_THEP1

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Protein
Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO
Gene
trmFO, Tpet_0195
Organism
Thermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + uracil(54) in tRNA + FADH2 = tetrahydrofolate + 5-methyluracil(54) in tRNA + FAD.UniRule annotation

Cofactori

FAD By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126FAD By similarity

GO - Molecular functioni

  1. 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity Source: UniProtKB-HAMAP
  2. flavin adenine dinucleotide binding Source: UniProtKB-HAMAP
  3. methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciTPET390874:GHJI-199-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO (EC:2.1.1.74)
    Alternative name(s):
    Folate-dependent tRNA (uracil-5-)-methyltransferase
    Folate-dependent tRNA(M-5-U54)-methyltransferase
    Gene namesi
    Name:trmFO
    Ordered Locus Names:Tpet_0195
    OrganismiThermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995)
    Taxonomic identifieri390874 [NCBI]
    Taxonomic lineageiBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga
    ProteomesiUP000006558: Chromosome

    Subcellular locationi

    Cytoplasm By similarity UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFOUniRule annotation
    PRO_0000346417Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi390874.Tpet_0195.

    Structurei

    3D structure databases

    ProteinModelPortaliA5IJ51.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MnmG family. TrmFO subfamily.

    Phylogenomic databases

    eggNOGiCOG1206.
    HOGENOMiHOG000252054.
    KOiK04094.
    OMAiEIYFEGC.
    OrthoDBiEOG6J74VT.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01037. TrmFO.
    InterProiIPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01134. GIDA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00137. gid_trmFO. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    A5IJ51-1 [UniParc]FASTAAdd to Basket

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    MIVNVIGAGL AGSEVAYNLG KRGIRVRLFE MRPKKMTEVH KTGYFAELVC    50
    SNSLKSEDIT NAEGLLKAEM KLMGSITLEA AEKARVPSGK ALAVDRNIFA 100
    KEVTEAIESL ESVEVIREEV TEFDPEEGLW VVATGPATSD GLFSFLRNLL 150
    GDDFLFFFDA VSPIVTFESI DMEHAFWGDR FGKGKDYINC PLTDGEYEEL 200
    WKALVEAEVI EMEDFDRKLL FERCQPIEEI ARSGKDALRY GPLRPTGLVD 250
    PRTGKEPYAV VQLRREDKEG RFYSLVGFQT RLKWNEQKRV LRKIPCLRNA 300
    EIVRYGVMHR NVYINSPKLL DIFFRLKKQP NIFFAGQITG VEGYMESAAS 350
    GIYVAYNVYR ILKGLSPLKL PEETMMGALF SYIIEKVEGD LKPMYANFGL 400
    LPPLKTRVKD KFGKRKKLAE RAIEAMRKFL EEYPW 435
    Length:435
    Mass (Da):49,557
    Last modified:June 26, 2007 - v1
    Checksum:i969BD5B076202902
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000702 Genomic DNA. Translation: ABQ46224.1.
    RefSeqiYP_001243800.1. NC_009486.1.

    Genome annotation databases

    EnsemblBacteriaiABQ46224; ABQ46224; Tpet_0195.
    GeneIDi5170571.
    KEGGitpt:Tpet_0195.
    PATRICi23943115. VBIThePet65348_0195.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000702 Genomic DNA. Translation: ABQ46224.1 .
    RefSeqi YP_001243800.1. NC_009486.1.

    3D structure databases

    ProteinModelPortali A5IJ51.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 390874.Tpet_0195.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ46224 ; ABQ46224 ; Tpet_0195 .
    GeneIDi 5170571.
    KEGGi tpt:Tpet_0195.
    PATRICi 23943115. VBIThePet65348_0195.

    Phylogenomic databases

    eggNOGi COG1206.
    HOGENOMi HOG000252054.
    KOi K04094.
    OMAi EIYFEGC.
    OrthoDBi EOG6J74VT.

    Enzyme and pathway databases

    BioCyci TPET390874:GHJI-199-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01037. TrmFO.
    InterProi IPR004417. Folate-dep_Ribothymidyl_synth.
    IPR002218. GIDA-rel.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01134. GIDA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00137. gid_trmFO. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RKU-1 / ATCC BAA-488 / DSM 13995.

    Entry informationi

    Entry nameiTRMFO_THEP1
    AccessioniPrimary (citable) accession number: A5IJ51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: June 26, 2007
    Last modified: May 14, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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