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A5IIP0 (UPPP_THEP1) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Undecaprenyl-diphosphatase

EC=3.6.1.27
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene names
Name:uppP
Ordered Locus Names:Tpet_0034
OrganismThermotoga petrophila (strain RKU-1 / ATCC BAA-488 / DSM 13995) [Complete proteome] [HAMAP]
Taxonomic identifier390874 [NCBI]
Taxonomic lineageBacteriaThermotogaeThermotogalesThermotogaceaeThermotoga

Protein attributes

Sequence length237 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP-Rule MF_01006

Catalytic activity

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate. HAMAP-Rule MF_01006

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01006.

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Sequence similarities

Belongs to the UppP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 237237Undecaprenyl-diphosphatase HAMAP-Rule MF_01006
PRO_1000062819

Regions

Transmembrane38 – 5821Helical; Potential
Transmembrane65 – 8521Helical; Potential
Transmembrane92 – 11221Helical; Potential
Transmembrane126 – 14621Helical; Potential
Transmembrane166 – 18621Helical; Potential
Transmembrane191 – 21121Helical; Potential
Transmembrane217 – 23721Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
A5IIP0 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: 6369CA37DF0ACC55

FASTA23726,182
        10         20         30         40         50         60 
MDLLLGIIQG LTEFLPVSSS GHLTLLSHLL KTDLNAYQTA VLHLGTLVSV VLFAFDGIRR 

        70         80         90        100        110        120 
SLRSWRIILN LIVSTIPAGV FGVLFEKQID QLFSSPRFLP LFFSVTALIL MFTRYSSSGE 

       130        140        150        160        170        180 
KRMENMSFLD ALLVGIAQLF ALFPGISRSG ITVSSLLFMK YRGEDALQYS FLMSIPVVLG 

       190        200        210        220        230 
AGILGLEKGN ITILAPIFAF LSGLFALYVL SRSVRSGKIW QFSYYCLFVA ILSYLVG 

« Hide

References

[1]"Complete sequence of Thermotoga petrophila RKU-1."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Sims D., Brettin T., Bruce D., Detter J.C., Han C., Tapia R., Schmutz J., Larimer F., Land M., Hauser L. expand/collapse author list , Kyrpides N., Mikhailova N., Nelson K., Gogarten J.P., Noll K., Richardson P.
Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: RKU-1 / ATCC BAA-488 / DSM 13995.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000702 Genomic DNA. Translation: ABQ46063.1.
RefSeqYP_001243639.1. NC_009486.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING390874.Tpet_0034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ46063; ABQ46063; Tpet_0034.
GeneID5171587.
KEGGtpt:Tpet_0034.
PATRIC23942785. VBIThePet65348_0034.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1968.
HOGENOMHOG000218357.
KOK06153.
OMAWEFLATG.
OrthoDBEOG6QP13M.
ProtClustDBCLSK795538.

Enzyme and pathway databases

BioCycTPET390874:GHJI-34-MONOMER.

Family and domain databases

HAMAPMF_01006. Undec_diphosphatase.
InterProIPR003824. UppP.
[Graphical view]
PfamPF02673. BacA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUPPP_THEP1
AccessionPrimary (citable) accession number: A5IIP0
Entry history
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: June 26, 2007
Last modified: February 19, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families