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A5IHB4

- TRMB_LEGPC

UniProt

A5IHB4 - TRMB_LEGPC

Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

trmB

Organism
Legionella pneumophila (strain Corby)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 49 (01 Oct 2014)
      Sequence version 1 (26 Jun 2007)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561S-adenosyl-L-methionineUniRule annotation
    Binding sitei81 – 811S-adenosyl-L-methionineUniRule annotation
    Binding sitei108 – 1081S-adenosyl-L-methionineUniRule annotation
    Active sitei131 – 1311By similarity
    Binding sitei131 – 1311S-adenosyl-L-methionineUniRule annotation
    Binding sitei135 – 1351SubstrateUniRule annotation
    Binding sitei167 – 1671SubstrateUniRule annotation

    GO - Molecular functioni

    1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciLPNE400673:GCIT-549-MONOMER.
    UniPathwayiUPA00989.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
    Alternative name(s):
    tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
    tRNA(m7G46)-methyltransferaseUniRule annotation
    Gene namesi
    Name:trmBUniRule annotation
    Ordered Locus Names:LPC_2863
    OrganismiLegionella pneumophila (strain Corby)
    Taxonomic identifieri400673 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
    ProteomesiUP000001569: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 225225tRNA (guanine-N(7)-)-methyltransferasePRO_1000064400Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi400673.LPC_2863.

    Structurei

    3D structure databases

    ProteinModelPortaliA5IHB4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni204 – 2074Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0220.
    HOGENOMiHOG000073968.
    KOiK03439.
    OMAiMSTENEN.
    OrthoDBiEOG6K6VBC.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_01057. tRNA_methyltr_TrmB.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view]
    PfamiPF02390. Methyltransf_4. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
    PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    A5IHB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRKIKSYVL RAGRISNRQQ QGLDLWLEDY ELKFDSPSPW NFAKEFGRHD    50
    ADTIVEIGFG MGTSLFTMAM NNPQCNYLGI EVHKAGVGSL VADLHEHQIT 100
    NVRVVVHDAV DVLQTKIPEN SLAGVQIFFP DPWHKKRHHK RRLIQSEFIQ 150
    MLVKKIRPSG FIHCATDWED YAEHILNVLS SESALFNQQK EGGYSPRPDS 200
    RPLTKFEQRG ERLGHGVWDL VFIKK 225
    Length:225
    Mass (Da):25,921
    Last modified:June 26, 2007 - v1
    Checksum:iDF74E5BEA3753A95
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000675 Genomic DNA. Translation: ABQ56764.1.
    RefSeqiYP_001252110.1. NC_009494.2.

    Genome annotation databases

    EnsemblBacteriaiABQ56764; ABQ56764; LPC_2863.
    GeneIDi5182641.
    KEGGilpc:LPC_2863.
    PATRICi22312315. VBILegPne45588_2961.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000675 Genomic DNA. Translation: ABQ56764.1 .
    RefSeqi YP_001252110.1. NC_009494.2.

    3D structure databases

    ProteinModelPortali A5IHB4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 400673.LPC_2863.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABQ56764 ; ABQ56764 ; LPC_2863 .
    GeneIDi 5182641.
    KEGGi lpc:LPC_2863.
    PATRICi 22312315. VBILegPne45588_2961.

    Phylogenomic databases

    eggNOGi COG0220.
    HOGENOMi HOG000073968.
    KOi K03439.
    OMAi MSTENEN.
    OrthoDBi EOG6K6VBC.

    Enzyme and pathway databases

    UniPathwayi UPA00989 .
    BioCyci LPNE400673:GCIT-549-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_01057. tRNA_methyltr_TrmB.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR003358. tRNA_(Gua-N-7)_MeTrfase.
    [Graphical view ]
    Pfami PF02390. Methyltransf_4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
    PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
      Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Corby.

    Entry informationi

    Entry nameiTRMB_LEGPC
    AccessioniPrimary (citable) accession number: A5IHB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: June 26, 2007
    Last modified: October 1, 2014
    This is version 49 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3