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Protein

Argininosuccinate lyase

Gene

argH

Organism
Legionella pneumophila (strain Corby)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.UniRule annotation

Pathwayi: L-arginine biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Argininosuccinate synthase (argG)
  3. Argininosuccinate lyase (argH)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-arginine from L-ornithine and carbamoyl phosphate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00114.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate lyaseUniRule annotation (EC:4.3.2.1UniRule annotation)
Short name:
ASALUniRule annotation
Alternative name(s):
ArginosuccinaseUniRule annotation
Gene namesi
Name:argHUniRule annotation
Ordered Locus Names:LPC_2851
OrganismiLegionella pneumophila (strain Corby)
Taxonomic identifieri400673 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000004931 – 411Argininosuccinate lyaseAdd BLAST411

Structurei

3D structure databases

ProteinModelPortaliA5IHA2.
SMRiA5IHA2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000242744.
KOiK01755.
OMAiSIMPHKK.
OrthoDBiPOG091H026A.

Family and domain databases

CDDicd01359. Argininosuccinate_lyase. 1 hit.
Gene3Di1.10.275.10. 2 hits.
HAMAPiMF_00006. Arg_succ_lyase. 1 hit.
InterProiView protein in InterPro
IPR029419. Arg_succ_lyase_C.
IPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
PANTHERiPTHR43814. PTHR43814. 1 hit.
PfamiView protein in Pfam
PF14698. ASL_C2. 1 hit.
PF00206. Lyase_1. 1 hit.
PRINTSiPR00149. FUMRATELYASE.
SUPFAMiSSF48557. SSF48557. 1 hit.
TIGRFAMsiTIGR00838. argH. 1 hit.
PROSITEiView protein in PROSITE
PS00163. FUMARATE_LYASES. 1 hit.

Sequencei

Sequence statusi: Complete.

A5IHA2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNKTWGGRF KKSLDSGVNQ FNASLSFDHV LFDQDINGSQ VHVKQLAKQK
60 70 80 90 100
ILTEVESQAI YSALEEIRSE IKQGQYSFNV RDEEDIHMFI EQLLIQKIGD
110 120 130 140 150
LGKKLHTGRS RNDQVALDLR LYTRDKGCLI NELLTRLIDC LDDLTSKHQQ
160 170 180 190 200
DLMPGYTHLQ QAQPVTLGAY FNAYQCMFGR DKSRLEDWFK RMNYSPLGAG
210 220 230 240 250
ALAGSTLPLD REWVAESLGF AGIIPNTLDA VSDRDFVIEL CSVAAMIMMH
260 270 280 290 300
LSRLCEDLIL WSTQEFNFVI LDDAFATGSS LMPNKKNPDV PELIRGKSGR
310 320 330 340 350
VYGHLMAILT VMKGLPLAYN KDMQEDKEGL FDTINTIIAC LQMITPFLQS
360 370 380 390 400
LTFNTLLMKT KAQSGYLDAT AILESLVMKG MPFRDAHHQV GAWIAEAIEK
410
QCSLNELLKG G
Length:411
Mass (Da):46,242
Last modified:June 26, 2007 - v1
Checksum:i1B573B9CAF1FF8E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA. Translation: ABQ56752.1.

Genome annotation databases

EnsemblBacteriaiABQ56752; ABQ56752; LPC_2851.
KEGGilpc:LPC_2851.

Similar proteinsi

Entry informationi

Entry nameiARLY_LEGPC
AccessioniPrimary (citable) accession number: A5IHA2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: February 28, 2018
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program