A5IGK7 (TDH_LEGPC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
L-threonine 3-dehydrogenase
EC=1.1.1.103

Gene names

Name:	tdh
Ordered Locus Names:	LPC_2592

Organism

Legionella pneumophila (strain Corby) [Complete proteome] [HAMAP]

Taxonomic identifier

400673 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH. HAMAP MF_00627
Cofactor	Binds 2 zinc ions per subunit By similarity. HAMAP MF_00627
Pathway	Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. HAMAP MF_00627
Subunit structure	Homotetramer By similarity. HAMAP MF_00627
Subcellular location	Cytoplasm By similarity HAMAP MF_00627.
Sequence similarities	Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding NAD Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	threonine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-threonine 3-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	L-threonine 3-dehydrogenase HAMAP MF_00627		PRO_1000051643
Sites
	Metal binding	38	1	Zinc 1; catalytic By similarity
	Metal binding	63	1	Zinc 1; catalytic By similarity
	Metal binding	93	1	Zinc 2 By similarity
	Metal binding	96	1	Zinc 2 By similarity
	Metal binding	99	1	Zinc 2 By similarity
	Metal binding	107	1	Zinc 2 By similarity
	Metal binding	148	1	Zinc 1; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	A5IGK7 [UniParc]. Last modified June 26, 2007. Version 1. Checksum: 6DF5DBD9D98187FF	FASTA	340	37,196
	10 20 30 40 50 60 MKSLVKAKKE PGIWMQDVPV PEYGVNDVLI KIKRTAICGT DIHIYSWDEW AQATIPVPMT 70 80 90 100 110 120 VGHEFYGEIV EVGKEVQGLK VGQRVSGEGH ITCGFCRNCR AGKRHLCRNT LGVGVNRPGC 130 140 150 160 170 180 FAEYLALPAT NVIALPDNIT EEQAAILDPF GNAAHCALAF DVVGEDVLIT GAGPIGIMAA 190 200 210 220 230 240 AIVRHIGARH VVITDVNDHR LELARQMGVS RAVNVKYQKL SDVANELGML EGFDVGLEMS 250 260 270 280 290 300 GNPMALNDMM KAMNHGGHVA LLGIPPQETP IDWNQVIFKG LVIKGIYGRE MFETWYKMIA 310 320 330 340 MLQSGLNISP VITHNFPVDE YQHAFQIMAS GQSGKVILNW

References

[1]

"Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island." Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K. Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Corby.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000675 Genomic DNA. Translation: ABQ56507.1.
RefSeq	YP_001251853.1. NC_009494.2.
3D structure databases
ProteinModelPortal	A5IGK7.
ModBase	Search...
Protein-protein interaction databases
STRING	A5IGK7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5180418.
GenomeReviews	Gene locus LPC_2592 in contig CP000675_GR.
KEGG	lpc:LPC_2592.
PATRIC	22311761. VBILegPne45588_2691.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1063.
HOGENOM	HBG753318.
OMA	MMRSGMS.
ProtClustDB	PRK05396.
Enzyme and pathway databases
BioCyc	LPNE400673:LPC_2592-MONOMER.
Family and domain databases
HAMAP	MF_00627. Thr_dehydrog. [Tree]
InterPro	IPR013149. ADH_C. IPR013154. ADH_GroES-like. IPR002085. ADH_SF_Zn-type. IPR002328. ADH_Zn_CS. IPR011032. GroES-like. IPR004627. L-Threonine_3-DHase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00060.
PANTHER	PTHR11695. ADH_Sf_Zn. 1 hit.
Pfam	PF08240. ADH_N. 1 hit. PF00107. ADH_zinc_N. 1 hit. [Graphical view]
SUPFAM	SSF50129. GroES_like. 1 hit.
TIGRFAMs	TIGR00692. Tdh. 1 hit.
PROSITE	PS00059. ADH_ZINC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TDH_LEGPC

Accession

Primary (citable) accession number: A5IGK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	June 26, 2007
Last modified:	December 14, 2011
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program