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Protein

Exodeoxyribonuclease 7 large subunit

Gene

xseA

Organism
Legionella pneumophila (strain Corby)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

BioCyciLPNE400673:GCIT-931-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exodeoxyribonuclease 7 large subunitUniRule annotation (EC:3.1.11.6UniRule annotation)
Alternative name(s):
Exodeoxyribonuclease VII large subunitUniRule annotation
Short name:
Exonuclease VII large subunitUniRule annotation
Gene namesi
Name:xseAUniRule annotation
Ordered Locus Names:LPC_2470
OrganismiLegionella pneumophila (strain Corby)
Taxonomic identifieri400673 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Exodeoxyribonuclease 7 large subunitPRO_1000048776Add
BLAST

Interactioni

Subunit structurei

Heterooligomer composed of large and small subunits.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the XseA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiYTRFENI.
OrthoDBiEOG64R65J.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.

Sequencei

Sequence statusi: Complete.

A5IG90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQLPILTV SQLNRQVKGF LENEIGLVHV EGEISNLSKP SSGHYYFTLK
60 70 80 90 100
DSTAQIRCAF FKNRHSSSLL RNFNDGQQIV ASGKLSLYEA RGEYQLIVEE
110 120 130 140 150
IVEAGMGVLY QRFEELKIKL ASEGLFNPER KKTLPRIPET IGIITSPTGA
160 170 180 190 200
AIQDILSTLA RRFPIARVII YPSEVQGQTA PQQLVNALKL ANAHKRCQVL
210 220 230 240 250
ILARGGGSIE DLWAFNDEYL ARQIAISEIP VVSGIGHETD FTIADFVADY
260 270 280 290 300
RAETPTAAAT AVTPNCIELF NILDTAIYRL HDAIIRLIKG LQLKLNHLID
310 320 330 340 350
KIASPRQAIS TYWQTLDYLE RQLISAMTQF INLNINKVNI FSTQLQASNP
360 370 380 390 400
KIQIERTKIQ LQQLIMQLTQ EIRIKVNQLK NQLSTNLSTL HAVSPLATLD
410 420 430 440
RGYAIVSKNQ RILFAAQQAQ IGDTINIRLA KGSLACEVTQ IKD
Length:443
Mass (Da):49,446
Last modified:June 26, 2007 - v1
Checksum:iA0259330BCF783C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA. Translation: ABQ56390.1.
RefSeqiWP_011945942.1. NC_009494.2.

Genome annotation databases

EnsemblBacteriaiABQ56390; ABQ56390; LPC_2470.
KEGGilpc:LPC_2470.
PATRICi22311513. VBILegPne45588_2568.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA. Translation: ABQ56390.1.
RefSeqiWP_011945942.1. NC_009494.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ56390; ABQ56390; LPC_2470.
KEGGilpc:LPC_2470.
PATRICi22311513. VBILegPne45588_2568.

Phylogenomic databases

HOGENOMiHOG000229265.
KOiK03601.
OMAiYTRFENI.
OrthoDBiEOG64R65J.

Enzyme and pathway databases

BioCyciLPNE400673:GCIT-931-MONOMER.

Family and domain databases

HAMAPiMF_00378. Exonuc_7_L.
InterProiIPR003753. Exonuc_VII_L.
IPR020579. Exonuc_VII_lsu_C.
IPR025824. OB-fold_nuc-bd_dom.
[Graphical view]
PfamiPF02601. Exonuc_VII_L. 1 hit.
PF13742. tRNA_anti_2. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00237. xseA. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
    Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Corby.

Entry informationi

Entry nameiEX7L_LEGPC
AccessioniPrimary (citable) accession number: A5IG90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: November 11, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.