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A5IFN1 (TYPH_LEGPC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Ordered Locus Names:LPC_2257
OrganismLegionella pneumophila (strain Corby) [Complete proteome] [HAMAP]
Taxonomic identifier400673 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

Protein attributes

Sequence length517 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Sequence caution

The sequence ABQ56181.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 517517Putative thymidine phosphorylase HAMAP-Rule MF_00703
PRO_0000314700

Sequences

Sequence LengthMass (Da)Tools
A5IFN1 [UniParc].

Last modified January 15, 2008. Version 2.
Checksum: 63735B276D67D4E4

FASTA51755,259
        10         20         30         40         50         60 
MHHSFLSANG GVVMSKKTAH GLRLKHLGIK TYHEAIIYMR EDCHVCHSEG FEVQTRIQVT 

        70         80         90        100        110        120 
LGQHSIIATL NVVTSELLAP GEAGLSDYAW DALHAKEGDE IQVSHPKPLE SLSYVHTKIY 

       130        140        150        160        170        180 
GNELSYEQMK VIIDDVLSGR LSDVQISAFL AASSAGRLTR TEIMKLTKAM IDSGDRLSWS 

       190        200        210        220        230        240 
SPLVVDKHCV GGLPGNRTTL IVVPIVAAFG LMIPKTSSRA ITSPAGTADT METLAPVHLS 

       250        260        270        280        290        300 
PQKMRQVVEQ ENGCIVWGGA VSLSPADDVL IRVERAIDLD SEGQLVASIL SKKIATGATH 

       310        320        330        340        350        360 
AVIDIPVGPT AKVRNQSMAL LLKQSLEEVG NELGLVVHTI LTDGSQPVGH GIGPSLEARD 

       370        380        390        400        410        420 
VMSVLQGLPD APNDLRERAL TLAGAALECS SKVQPGLGKS IAKQILESGK AFKKFQAICE 

       430        440        450        460        470        480 
AQGGMRELTK ARFTHPVVAA KEGKVSLIDN RKLAKIAKLA GAPKSKSAGI DLHAHVGESV 

       490        500        510 
EQGEPLFTIH SESSGELNYA CDLLRDKQDI IILGENS 

« Hide

References

[1]"Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Corby.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000675 Genomic DNA. Translation: ABQ56181.1. Different initiation.
RefSeqYP_001251527.1. NC_009494.2.

3D structure databases

ProteinModelPortalA5IFN1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING400673.LPC_2257.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABQ56181; ABQ56181; LPC_2257.
GeneID5180089.
KEGGlpc:LPC_2257.
PATRIC22311077. VBILegPne45588_2352.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0213.
HOGENOMHOG000252767.
KOK00758.
OrthoDBEOG61ZTGG.
ProtClustDBPRK04350.

Enzyme and pathway databases

BioCycLPNE400673:GCIT-1142-MONOMER.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_00703. Thymid_phosp_2.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02645. ARCH_P_rylase. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_LEGPC
AccessionPrimary (citable) accession number: A5IFN1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: February 19, 2014
This is version 44 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families