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A5IFN1

- TYPH_LEGPC

UniProt

A5IFN1 - TYPH_LEGPC

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Protein

Putative thymidine phosphorylase

Gene

LPC_2257

Organism
Legionella pneumophila (strain Corby)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. thymidine phosphorylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciLPNE400673:GCIT-1142-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Ordered Locus Names:LPC_2257
OrganismiLegionella pneumophila (strain Corby)
Taxonomic identifieri400673 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
ProteomesiUP000001569: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 517517Putative thymidine phosphorylasePRO_0000314700Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi400673.LPC_2257.

Structurei

3D structure databases

ProteinModelPortaliA5IFN1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_00703. Thymid_phosp_2.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5IFN1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHHSFLSANG GVVMSKKTAH GLRLKHLGIK TYHEAIIYMR EDCHVCHSEG
60 70 80 90 100
FEVQTRIQVT LGQHSIIATL NVVTSELLAP GEAGLSDYAW DALHAKEGDE
110 120 130 140 150
IQVSHPKPLE SLSYVHTKIY GNELSYEQMK VIIDDVLSGR LSDVQISAFL
160 170 180 190 200
AASSAGRLTR TEIMKLTKAM IDSGDRLSWS SPLVVDKHCV GGLPGNRTTL
210 220 230 240 250
IVVPIVAAFG LMIPKTSSRA ITSPAGTADT METLAPVHLS PQKMRQVVEQ
260 270 280 290 300
ENGCIVWGGA VSLSPADDVL IRVERAIDLD SEGQLVASIL SKKIATGATH
310 320 330 340 350
AVIDIPVGPT AKVRNQSMAL LLKQSLEEVG NELGLVVHTI LTDGSQPVGH
360 370 380 390 400
GIGPSLEARD VMSVLQGLPD APNDLRERAL TLAGAALECS SKVQPGLGKS
410 420 430 440 450
IAKQILESGK AFKKFQAICE AQGGMRELTK ARFTHPVVAA KEGKVSLIDN
460 470 480 490 500
RKLAKIAKLA GAPKSKSAGI DLHAHVGESV EQGEPLFTIH SESSGELNYA
510
CDLLRDKQDI IILGENS
Length:517
Mass (Da):55,259
Last modified:January 15, 2008 - v2
Checksum:i63735B276D67D4E4
GO

Sequence cautioni

The sequence ABQ56181.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000675 Genomic DNA. Translation: ABQ56181.1. Different initiation.
RefSeqiYP_001251527.1. NC_009494.2.

Genome annotation databases

EnsemblBacteriaiABQ56181; ABQ56181; LPC_2257.
GeneIDi5180089.
KEGGilpc:LPC_2257.
PATRICi22311077. VBILegPne45588_2352.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000675 Genomic DNA. Translation: ABQ56181.1 . Different initiation.
RefSeqi YP_001251527.1. NC_009494.2.

3D structure databases

ProteinModelPortali A5IFN1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 400673.LPC_2257.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABQ56181 ; ABQ56181 ; LPC_2257 .
GeneIDi 5180089.
KEGGi lpc:LPC_2257.
PATRICi 22311077. VBILegPne45588_2352.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

BioCyci LPNE400673:GCIT-1142-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_00703. Thymid_phosp_2.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR028579. Thym_Pase_Put.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
    Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
    Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Corby.

Entry informationi

Entry nameiTYPH_LEGPC
AccessioniPrimary (citable) accession number: A5IFN1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: October 1, 2014
This is version 46 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3