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Protein

Putative thymidine phosphorylase

Gene

LPC_2257

Organism
Legionella pneumophila (strain Corby)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Putative thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Ordered Locus Names:LPC_2257
OrganismiLegionella pneumophila (strain Corby)
Taxonomic identifieri400673 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003147001 – 517Putative thymidine phosphorylaseAdd BLAST517

Structurei

3D structure databases

ProteinModelPortaliA5IFN1
SMRiA5IFN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000252767
KOiK00758
OrthoDBiPOG091H02BC

Family and domain databases

Gene3Di3.40.1030.10, 2 hits
3.90.1170.30, 1 hit
HAMAPiMF_00703 Thymid_phosp_2, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR028579 Thym_Pase_Put
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 2 hits
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

A5IFN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHHSFLSANG GVVMSKKTAH GLRLKHLGIK TYHEAIIYMR EDCHVCHSEG
60 70 80 90 100
FEVQTRIQVT LGQHSIIATL NVVTSELLAP GEAGLSDYAW DALHAKEGDE
110 120 130 140 150
IQVSHPKPLE SLSYVHTKIY GNELSYEQMK VIIDDVLSGR LSDVQISAFL
160 170 180 190 200
AASSAGRLTR TEIMKLTKAM IDSGDRLSWS SPLVVDKHCV GGLPGNRTTL
210 220 230 240 250
IVVPIVAAFG LMIPKTSSRA ITSPAGTADT METLAPVHLS PQKMRQVVEQ
260 270 280 290 300
ENGCIVWGGA VSLSPADDVL IRVERAIDLD SEGQLVASIL SKKIATGATH
310 320 330 340 350
AVIDIPVGPT AKVRNQSMAL LLKQSLEEVG NELGLVVHTI LTDGSQPVGH
360 370 380 390 400
GIGPSLEARD VMSVLQGLPD APNDLRERAL TLAGAALECS SKVQPGLGKS
410 420 430 440 450
IAKQILESGK AFKKFQAICE AQGGMRELTK ARFTHPVVAA KEGKVSLIDN
460 470 480 490 500
RKLAKIAKLA GAPKSKSAGI DLHAHVGESV EQGEPLFTIH SESSGELNYA
510
CDLLRDKQDI IILGENS
Length:517
Mass (Da):55,259
Last modified:January 15, 2008 - v2
Checksum:i63735B276D67D4E4
GO

Sequence cautioni

The sequence ABQ56181 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA Translation: ABQ56181.1 Different initiation.

Genome annotation databases

EnsemblBacteriaiABQ56181; ABQ56181; LPC_2257
KEGGilpc:LPC_2257

Similar proteinsi

Entry informationi

Entry nameiTYPH_LEGPC
AccessioniPrimary (citable) accession number: A5IFN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: March 28, 2018
This is version 66 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health