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A5IFJ9 (ATPA1_LEGPC) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ATP synthase subunit alpha 1
EC=3.6.3.14
Alternative name(s):
ATP synthase F1 sector subunit alpha 1
F-ATPase subunit alpha 1
Gene names
Name:atpA1
Ordered Locus Names:LPC_2225
OrganismLegionella pneumophila (strain Corby) [Complete proteome] [HAMAP]
Taxonomic identifier400673 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP MF_01346

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP MF_01346.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 490490ATP synthase subunit alpha 1 HAMAP MF_01346
PRO_0000339035

Regions

Nucleotide binding171 – 1788ATP Potential

Sites

Site3641Required for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
A5IFJ9 [UniParc].

Last modified June 26, 2007. Version 1.
Checksum: BBAE5EAE185C4CFA

FASTA49054,905
        10         20         30         40         50         60 
MNWSNTPSFL EKQRQRLKRY QFQIKVSEQG RVVSVGDGII WIKGLPGAAI DEILISEDEC 

        70         80         90        100        110        120 
CIAMVFHLTE ELVGAVMLVQ TKKLKAGTPI FPLKRVLSIP VGDKLLGRVI DPLGHPLDGG 

       130        140        150        160        170        180 
EIPPHEEQGL LDRLSPHILH RDFVNRPLYT GNKMLDNLIP IGKGQRELLI GDNGLGKSAL 

       190        200        210        220        230        240 
ALDIVMNQKD KKVYCVYVLI GQKRSTVSST IQLLKKANAL DYTTVVVAQA TALPGLLYLA 

       250        260        270        280        290        300 
PFAGCAIAEH WMKKGLDTLV VYDDLSAHAN SYRELSLLLR RPPGREAFPA DIFYLHSRLL 

       310        320        330        340        350        360 
ERSTCLSPAM GGGSMTALPI IETKEGEMAT YIPTNLISIT DGQIFFDESL FSSGFLPAID 

       370        380        390        400        410        420 
ITKSVSRVGA KAQHPQIKKE SGRMKLDYLQ FLDLELFTRF GAKLDAKMQK QIQKGRVLRE 

       430        440        450        460        470        480 
ILKQERFSPL PIEFQLAWLI AYNEGFFDES NLEDIPQILK KIEKEIKQSN LSLGSPREQW 

       490 
KKAIKEWLMA

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References

[1]"Identification and characterization of a new conjugation/ type IVA secretion system (trb/tra) of L. pneumophila Corby localized on a mobile genomic island."
Gloeckner G., Albert-Weissenberger C., Weinmann E., Jacobi S., Schunder E., Steinert M., Buchrieser C., Hacker J., Heuner K.
Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Corby.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000675 Genomic DNA. Translation: ABQ56149.1.
RefSeqYP_001251495.1. NC_009494.2.

3D structure databases

ProteinModelPortalA5IFJ9.
ModBaseSearch...

Protein-protein interaction databases

STRINGA5IFJ9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5180057.
GenomeReviewsGene locus LPC_2225 in contig CP000675_GR.
KEGGlpc:LPC_2225.
PATRIC22311009. VBILegPne45588_2318.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0056.
HOGENOMHBG565875.
OMAHAQTYRE.
ProtClustDBPRK13343.

Enzyme and pathway databases

BioCycLPNE400673:LPC_2225-MONOMER.

Family and domain databases

HAMAPMF_01346. ATP_synth_alpha_bact.
[Tree]
InterProIPR020003. ATPase_a/bsu_AS.
IPR005294. ATPase_F1-cplx_asu.
IPR018118. ATPase_F1/A1-cplx_a/bsu_N.
IPR023366. ATPase_F1/A1-cplx_a_su_N.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
[Graphical view]
Gene3DG3DSA:2.40.30.20. G3DSA:2.40.30.20. 1 hit.
KOK02111.
PANTHERPTHR15184:SF3. ATPase_F1_a. 1 hit.
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
[Graphical view]
SUPFAMSSF47917. ATPase_a/b_C. 1 hit.
SSF50615. ATPase_a/b_N. 1 hit.
TIGRFAMsTIGR00962. AtpA. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATPA1_LEGPC
AccessionPrimary (citable) accession number: A5IFJ9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 26, 2007
Last modified: December 14, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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