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Protein

Catalase-peroxidase 1

Gene

katG1

Organism
Legionella pneumophila (strain Corby)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.UniRule annotation

Catalytic activityi

Donor + H2O2 = oxidized donor + 2 H2O.UniRule annotation
2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

heme bUniRule annotationNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei95Transition state stabilizerUniRule annotation1
Active sitei99Proton acceptorUniRule annotation1
Metal bindingi264Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase-peroxidase 1UniRule annotation (EC:1.11.1.21UniRule annotation)
Short name:
CP 1UniRule annotation
Alternative name(s):
Peroxidase/catalase 1UniRule annotation
Gene namesi
Name:katG1UniRule annotation
Ordered Locus Names:LPC_2090
OrganismiLegionella pneumophila (strain Corby)
Taxonomic identifieri400673 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003548161 – 721Catalase-peroxidase 1Add BLAST721

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki98 ↔ 223Tryptophyl-tyrosyl-methioninium (Trp-Tyr) (with M-249)UniRule annotation
Cross-linki223 ↔ 249Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with W-98)UniRule annotation

Post-translational modificationi

The covalent Trp-Tyr-Met adduct is important for the catalase, but not the peroxidase activity of the enzyme.UniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliA5IF70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peroxidase family. Peroxidase/catalase subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

A5IF70-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGKVGNTTT GCPVMHGGMT SAGTSNTAWW PNALNLDILH QHDTKTNPMG
60 70 80 90 100
KDFNYREEVK KLNFEALKKD LHALMTDSQA WWPADWGHYG GLMIRMSWHA
110 120 130 140 150
AGSYRVADGR GGAGTGNQRF APLNSWPDNV NLDKARRLLW PIKKKYGNKI
160 170 180 190 200
SWADLIVLAG TIAYESMGLK TFGFGFGRED IWHPEKDVYW GSEQEWLGAK
210 220 230 240 250
RYDDKDRQSL ETPLAAVQMG LIYVNPEGVN GQPDPLRTAQ DVRVTFGRMA
260 270 280 290 300
MNDEETVALT AGGHTVGKCH GNGNAKFLGP EPEAADIEDQ GLGWINKTTR
310 320 330 340 350
GIGRNTVSSG IEGAWTTHPT QWDNGYFYLL LNYDWELKKS PAGAWQWEPI
360 370 380 390 400
HIKEEDKPVD VEDPAIRHNP IMTDADMAIK MDPVYRKIAE RFYKDPDYFA
410 420 430 440 450
EVFARAWFKL THRDMGPKTR YIGPDVPKED LIWQDPVPAG NRAYDIAAAK
460 470 480 490 500
AKIAASNLTI GEMVSTAWDS ARTFRGSDKR GGANGARIRL KPQKDWEGNE
510 520 530 540 550
PQRLTKVLRI LEDIAADTGA SVADVIVLAG NVGIEKAAKA AGFDIIVPFA
560 570 580 590 600
PGRGDATDDM TDAESFDVLE PLHDGYRNWL KKAYDVRPEE LMLDRTQLMG
610 620 630 640 650
LTAHEMTVLV GGLRVLGTNH NNTQHGVFTD RVGALTNDFF VNLTDMANVW
660 670 680 690 700
IPSKDNLYEI RDRKAGNIKW TATRVDLVFG SNSILRSYAE VYAQDDNKGK
710 720
FIQDFVAAWT KVMNADRFDL A
Length:721
Mass (Da):80,488
Last modified:June 26, 2007 - v1
Checksum:iDE864894F5075A59
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA. Translation: ABQ56020.1.
RefSeqiWP_011947306.1. NC_009494.2.

Genome annotation databases

EnsemblBacteriaiABQ56020; ABQ56020; LPC_2090.
KEGGilpc:LPC_2090.
PATRICi22310719. VBILegPne45588_2173.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA. Translation: ABQ56020.1.
RefSeqiWP_011947306.1. NC_009494.2.

3D structure databases

ProteinModelPortaliA5IF70.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABQ56020; ABQ56020; LPC_2090.
KEGGilpc:LPC_2090.
PATRICi22310719. VBILegPne45588_2173.

Phylogenomic databases

HOGENOMiHOG000218110.
KOiK03782.
OMAiQPEEMML.
OrthoDBiPOG091H05R1.

Family and domain databases

HAMAPiMF_01961. Catal_peroxid. 1 hit.
InterProiIPR000763. Catalase_peroxidase.
IPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR019794. Peroxidases_AS.
[Graphical view]
PfamiPF00141. peroxidase. 2 hits.
[Graphical view]
PRINTSiPR00460. BPEROXIDASE.
PR00458. PEROXIDASE.
SUPFAMiSSF48113. SSF48113. 2 hits.
TIGRFAMsiTIGR00198. cat_per_HPI. 1 hit.
PROSITEiPS00436. PEROXIDASE_2. 1 hit.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKATG1_LEGPC
AccessioniPrimary (citable) accession number: A5IF70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: June 26, 2007
Last modified: November 2, 2016
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.