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Protein

Tetraacyldisaccharide 4'-kinase

Gene

lpxK

Organism
Legionella pneumophila (strain Corby)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).UniRule annotation

Catalytic activityi

ATP + (2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl phosphate) = ADP + (2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-4-O-phospho-beta-D-glucosaminyl)-(1->6)-(2-N,3-O-bis((3R)-3-hydroxytetradecanoyl)-alpha-D-glucosaminyl phosphate).UniRule annotation

Pathwayi: lipid IV(A) biosynthesis

This protein is involved in step 6 of the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. UDP-3-O-acyl-N-acetylglucosamine deacetylase (lpxC)
  3. no protein annotated in this organism
  4. no protein annotated in this organism
  5. no protein annotated in this organism
  6. Tetraacyldisaccharide 4'-kinase (lpxK)
This subpathway is part of the pathway lipid IV(A) biosynthesis, which is itself part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine, the pathway lipid IV(A) biosynthesis and in Glycolipid biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 63ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00359; UER00482.

Names & Taxonomyi

Protein namesi
Recommended name:
Tetraacyldisaccharide 4'-kinaseUniRule annotation (EC:2.7.1.130UniRule annotation)
Alternative name(s):
Lipid A 4'-kinaseUniRule annotation
Gene namesi
Name:lpxKUniRule annotation
Ordered Locus Names:LPC_1262
OrganismiLegionella pneumophila (strain Corby)
Taxonomic identifieri400673 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000499001 – 323Tetraacyldisaccharide 4'-kinaseAdd BLAST323

Structurei

3D structure databases

SMRiA5ICX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxK family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004953.
KOiK00912.
OMAiMDDGFQN.
OrthoDBiPOG091H000L.

Family and domain databases

HAMAPiMF_00409. LpxK. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR003758. Tetraacyldisaccharide_4-kinase.
PANTHERiPTHR42724. PTHR42724. 1 hit.
PfamiView protein in Pfam
PF02606. LpxK. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00682. lpxK. 1 hit.

Sequencei

Sequence statusi: Complete.

A5ICX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFFVNRIWY GNHFLQWILV PFSWLYRIVI RTRRWYLQRF CQQLYPIPII
60 70 80 90 100
VVGNVTVGGV GKTPLVIEIA KKIQQKGLKV GIVSRGYKAA IKHFPYEVKL
110 120 130 140 150
NDSAELVGDE PLMMARKINC PVVIAPKRNE AVRYLLDKHS VEIIISDDGL
160 170 180 190 200
QHYKMGRSIE IVVIDGMRKL GNGFCLPAGP LREPDSRLKQ VDFVIVNQGA
210 220 230 240 250
AEGTYSMELI PKNIVRLSTQ EEVSNDLFTS EVAAVAGIGN PQRFYSTLSQ
260 270 280 290 300
LGIKFNPYSY PDHHQFKPHD LNDIDLPVIM TEKDAVKCYS FSSDKLYYLP
310 320
VEAKLNDSFW EAFWSHQQLQ GYY
Length:323
Mass (Da):37,023
Last modified:June 26, 2007 - v1
Checksum:i4043BA70E9FF4FAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000675 Genomic DNA. Translation: ABQ55225.1.
RefSeqiWP_010947544.1. NC_009494.2.

Genome annotation databases

EnsemblBacteriaiABQ55225; ABQ55225; LPC_1262.
KEGGilpc:LPC_1262.

Similar proteinsi

Entry informationi

Entry nameiLPXK_LEGPC
AccessioniPrimary (citable) accession number: A5ICX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 26, 2007
Last modified: August 30, 2017
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families